(5S)-isomethadone | 561-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5S)-isomethadone
• 英文别名: (S)-1-dimethylamino-2-methyl-3.3-diphenyl-hexanone-(4)；(S)-1-Dimethylamino-2-methyl-3.3-diphenyl-hexanon-(4)；(S)-6-(dimethylamino)-5-methyl-4,4-diphenyl-3-hexanone；Levoisomethadone；(5S)-6-(dimethylamino)-5-methyl-4,4-diphenylhexan-3-one
• CAS: 561-10-4
• 化学式: C₂₁H₂₇NO
• 分子量: 309.451
• InChiKey: IFKPLJWIEQBPGG-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2-diphenyl-3-methyl-4-(dimethylamino)-butyronitrile 在 乙醚 、 甲苯 作用下， 生成 (5S)-isomethadone
  参考文献：
  名称：

  美沙酮及相关化合物的拆分。

  摘要：

  DOI：

  10.1021/ja01192a065

文献信息

• Method for processing lignocellulosic material
  申请人：——

  公开号：US20020192774A1

  公开（公告）日：2002-12-19

  A method wherein lignocellulosic biomass materials are converted into combustible fuel products. In particular, the method is a continuous process. involving wet oxidation or steam explosion, for fermentatively converting such biomass materials into ethanol using a process design that permits all or part of the process water from the ethanol fermentation process to be recycled to reduce the consumption of process water. The effluent from the ethanol fermentation step may be subjected to an anaerobic fermentation step generating methane and a water effluent in which the amount of potentially inhibitory substances is at a sub-inhibitory level, which in turn permits all or part of the effluent water from the anaerobic fermentation step to be recycled into the process.

  一种将木质纤维素生物质材料转化为可燃燃料产品的方法，具体而言，该方法是一种连续的过程，涉及湿法氧化或蒸汽爆炸，通过使用允许从乙醇发酵过程中回收全部或部分过程水以减少过程水消耗的过程设计，将这种生物质材料发酵转化为乙醇。乙醇发酵步骤的废液可以经过厌氧发酵步骤，产生甲烷和水废液，其中潜在的抑制物质的含量处于亚抑制水平，这反过来又允许将厌氧发酵步骤的全部或部分废液水回收到过程中。
• WHITENING DERMATOLOGICAL PREPARATIONS
  申请人：Kamachi Harumi

  公开号：US20090240070A1

  公开（公告）日：2009-09-24

  Disclosed is a dermatological preparation that are safe and are excellent in inhibiting and removing skin pigmentation and in inhibiting skin roughness. A dermatological preparation comprising a tocopherol aminoalkylcarboxylate and/or a salt thereof, the tocopherol aminoalkylcarboxylate being represented by Formula (I): wherein R 1 is a hydrogen atom or a lower alkyl group; R 2 and R 3 are each independently a hydrogen atom or a methyl group; X is a cycloalkylene group of 3 to 6 carbon atoms; and n is 0 or 1.

  本发明涉及一种皮肤科制剂，其安全有效地抑制和去除皮肤色素沉着，并抑制皮肤粗糙度。该皮肤科制剂包括一种生育酚氨基烷基羧酸酯和/或其盐，所述生育酚氨基烷基羧酸酯由式(I)表示：其中，R1是氢原子或低碳基；R2和R3各自独立地是氢原子或甲基基团；X是3至6个碳原子的环烷基团；n为0或1。
• NOVEL FUNGAL ENZYMES
  申请人：Gusakov Alexander Vasilievich

  公开号：US20120030838A1

  公开（公告）日：2012-02-02

  This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including washing of clothing, detergent processes, deinking and biobleaching of paper and pulp, and treatment of waste streams.

  本发明涉及新型酶和生产该酶的新方法。更具体地，本发明涉及多种真菌酶。描述了编码这种酶的核酸分子、组合物、重组和基因修饰宿主细胞以及使用方法。本发明还涉及一种将木质纤维素生物质转化为可发酵糖的方法，该方法使用降解木质纤维素材料的酶和新型酶组合，包括能从植物生物质中协同释放糖的酶。本发明还涉及使用新型酶和这种酶的组合物在各种其他过程中的方法，包括洗涤衣物、清洁剂过程、去墨和漂白纸浆以及处理废水流的方法。
• OVER-EXPRESSION OF NADH-DEPENDENT OXIDOREDUCTASE (FUCO) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE
  申请人：Miller Elliot N.

  公开号：US20140024086A1

  公开（公告）日：2014-01-23

  The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product.

  本发明涉及发现NADH依赖的丙二醇氧化还原酶（FucO）可以还原糠醛。这提供了一种改善用于生产所需产品的细菌和/或酵母细胞对糠醛耐受性的新方法。因此，提供了新的生物催化剂（细菌、真菌或酵母细胞），这些生物催化剂表现出对糠醛和5-羟甲基糠醛（5-HMF）的耐受性增加，同时提供了制备和使用这种生物催化剂生产所需产品的方法。
• METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION (LIGNO)CELLULOSIC MATERIAL
  申请人：EMALFARB Mark

  公开号：US20130280764A1

  公开（公告）日：2013-10-24

  The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma , and Talaromyces , plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms.

  本发明涉及改良后的丝状真菌生物，其在将纤维素材料中的复杂碳水化合物转化为简单糖方面具有改进的活性特性，包括属于以下组中选择的真菌生物属：Chrysosporium，Thielavia，Talaromyces，Thermomyces，Thermoascus，Neurospora，Aureobasidium，Filibasidium，Piromyces，Corynascus，Cryplococcus，Acremonium，Tolypocladium，Scytalidium，Schizophyllum，Sporotrichum，Penicillium，Gibberella，Myceliophthora，Mucor，Aspergillus，Fusarium，Humicola，Trichoderma和Talaromyces，以及其无性和有性形态。通过改变编码生产纤维二糖内酯，纤维二糖酸，葡萄糖内酯，葡萄糖酸和相关产物的酶的基因，通过各种突变方法，包括核苷酸替换，插入和删除，从而获得具有改进活性特性的丝状真菌生物，增加从改良生物中获得的酶混合物中的糖化水平。