N,N'-bis-(2-mercaptopropionyl)ethane-1,2-diamine | 687-72-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis-(2-mercaptopropionyl)ethane-1,2-diamine
• 英文别名: N,N'-ethylenebis(2-mercaptopropanamide)；N,N-ethylenebis(2-mercaptopropionamide)；N,N'-Ethylen-bis-(2-mercapto-propionamid)；N,N'-Ethylenebis(2-mercaptopropionamide)；2-sulfanyl-N-[2-(2-sulfanylpropanoylamino)ethyl]propanamide
• CAS: 687-72-9
• 化学式: C₈H₁₆N₂O₂S₂
• 分子量: 236.359
• InChiKey: NQBOCGBWMCQBAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  60.2
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ammonium pertechnetate 、 N,N'-bis-(2-mercaptopropionyl)ethane-1,2-diamine 、 对氯苯肼盐酸盐 、 四苯硼钠 以 甲醇 为溶剂， 以66%的产率得到
  参考文献：
  名称：

  Technetium diazenido-complexes. Part 2. Substitution chemistry of [TcCl(NNC6H4Cl-4)2(PPh3)2] and the synthesis of technetium diazenido-complexes directly from [NH4][TcO4]

  摘要：

  The bis(diazenido)technetium(III) complex [TcCl(NNR)2(PPh3)2] (R = C6H4Cl-4) reacted with bidentate ligands L with loss of one diazenide ligand to give [Tc(NNR)L2(PPh3)] (L = S2CNR2) and (TcCl(NNR)L(PPh3)2] (HL = maltol) in high yield. With dianionic tetradentate ligands L' complexes of the type cis-[Tc(NNR)L'(PPh3)] [L' = dianion of N,N'-bis(salicylidene)ethane-1,2-diamine (salen), S(CH2)2NMe(CH2)2NMe(CH2)2S or O2S(CH2)2NMe(CH2)2NMe(CH2)2SO2] were obtained. The crystal structure of the complex with L' = salen has been determined. It shows pseudo-octahedral co-ordination about the Tc with the NNR and PPh3 ligands cis. Direct reaction of [TcO4]- with arylhydrazine hydrochlorides generated a diazenide species in situ which reacts with S2CNR2 to give [TcCl(NNR)2(S2CNR2)2] and 2.2'-bipyridine (bipy) to give [TcCl(NNR)(bipy)2]+ isolated as a BPh4- salt.

  DOI：

  10.1039/dt9940001251
• 作为产物：
  描述：

  2-巯基丙酸甲酯 在 乙二胺 作用下， 以99%的产率得到N,N'-bis-(2-mercaptopropionyl)ethane-1,2-diamine
  参考文献：
  名称：

  Chain transfer agents for raft polymerization in aqueous media

  摘要：

  通过产生分子量范围较窄的方式合成的聚合物和共聚物可能具有与传统方式合成的聚合物不同的性质。然而，为了获得这种聚合物，必须控制聚合过程。一种控制聚合的类型是可逆加成-断裂链转移（RAFT）过程，具有类似活性聚合的特征。本发明揭示了一组二硫酸酯和三硫酸酯，适用作为RAFT聚合的链转移剂。本发明还揭示了在水性介质中进行的RAFT聚合过程。

  公开号：

  US06855840B2

文献信息

• Chain transfer agents for RAFT polymerization in aqueous media
  申请人：McCormick L. Charles

  公开号：US20060111531A1

  公开（公告）日：2006-05-25

  Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.

  通过产生分子量范围较窄的手段合成的聚合物和共聚物可以具有与传统手段合成的聚合物不同的性质。然而，为了获得这种聚合物，必须控制聚合过程。一种控制聚合的类型是可逆加成-解离链转移（RAFT）过程，具有活性聚合的特征。本发明揭示了一组适用于RAFT聚合的链转移剂的二硫酯和三硫酯。本发明还揭示了在水介质中进行的RAFT聚合。
• Potential Antiradiation Drugs. I. Amide, Hydroxamic Acid, and Hydrazine Derivatives of Mercapto Acids. Amino Thioacids¹
  作者：Edward R. Atkinson、G. Richard Handrick、Robert J. Bruni、Felix E. Granchelli

  DOI：10.1021/jm00325a007

  日期：1965.1
• Liao, Fen-Ling; Wang, Sue-Lein; Lin, Cheng-Hsien, Journal of the Chinese Chemical Society, 1994, vol. 41, # 5, p. 557 - 564
  作者：Liao, Fen-Ling、Wang, Sue-Lein、Lin, Cheng-Hsien、Huang, Shih-Tsorng

  DOI：——

  日期：——
• US6855840B2
  申请人：——

  公开号：US6855840B2

  公开（公告）日：2005-02-15
• US7186786B2
  申请人：——

  公开号：US7186786B2

  公开（公告）日：2007-03-06

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