4-(二甲氨基)萘-1-醇 | 54263-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-(二甲氨基)萘-1-醇
• 英文名称: 1-amino-4-naphthol
• 英文别名: 4-(Dimethylamino)naphthalen-1-ol
• CAS: 54263-79-5
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: QTXDOZVNRMLLPN-UHFFFAOYSA-N

物化性质

• 沸点：
  341.1±25.0 °C(Predicted)
• 密度：
  1.170±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(二甲氨基)萘-1-醇 在 叔丁基锂 、 sodium hydride 作用下， 以 四氢呋喃 、 环己烷 、 正戊烷 为溶剂， 反应 82.5h， 生成 5-碘代萘-1,4-二酮
  参考文献：
  名称：

  Direct Synthesis of 5-Substituted Naphthoquinones

  摘要：

  Peri-metalation of 4-(dimethylamino)-1-tert-butyldimethylsilyloxynaphthalene (5) followed by reaction with an electrophile and Jones' oxidation affords 5-substituted naphthoquinones.

  DOI：

  10.1021/jo010647h
• 作为产物：
  描述：

  聚合甲醛 、 4-氨基-1-萘酚 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以84%的产率得到4-(二甲氨基)萘-1-醇
  参考文献：
  名称：

  Direct Synthesis of 5-Substituted Naphthoquinones

  摘要：

  Peri-metalation of 4-(dimethylamino)-1-tert-butyldimethylsilyloxynaphthalene (5) followed by reaction with an electrophile and Jones' oxidation affords 5-substituted naphthoquinones.

  DOI：

  10.1021/jo010647h

文献信息

• PRODUCTION METHOD FOR ARYL (METH) ACRYLATE
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：US20160289160A1

  公开（公告）日：2016-10-06

  Provided is a low-tint (meth) acrylate aryl ester. This production method for (meth) acrylate aryl ester causes a specific hydroxyl group-containing aromatic compound and a (meth) acrylate anhydride to react, in the presence of a hindered phenol and a specific phosphite, and produces a (meth) acrylate aryl ester.

  提供的是低色调（甲基）丙烯酸酯芳基酯。该生产方法用于制备（甲基）丙烯酸酯芳基酯，通过在阻化酚和特定磷酸酯的存在下，使特定含羟基的芳香化合物和（甲基）丙烯酸酐反应，从而产生（甲基）丙烯酸酯芳基酯。
• Process for quantitative determination of substrate treated with oxidase
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：EP0100217A2

  公开（公告）日：1984-02-08

  A substrate in a sample can be determined quantitatively by measuring colorimetrically superoxide ion generated by treating the sample with a specific oxidase corresponding to the substrate to be determined, said oxidase treatment and measuring of the generated superoxide ion being conducted by using a reagent composition comprising (a) an oxidase, (b) peroxidase, (c) a phenol and/or an amine, (d) a thiol compound, (e) a color producing reagent to be reduced, and if necessary (f) a chelating agent. Further, the peroxidase can be replaced by (b') iron complex of porphyrin or ion chelate of complexane.

  使用与待测底物相对应的特定氧化酶处理样品后，可通过比色法测量生成的超氧离子，从而定量测定样品中的底物，所述氧化酶处理和测量生成的超氧离子是通过使用试剂组合物进行的，该试剂组合物包括 (a) 氧化酶、(b) 过氧化物酶、(c) 苯酚和/或胺、(d) 硫醇化合物、(e) 待还原的发色试剂，以及必要时 (f) 螯合剂。此外，过氧化物酶还可以用（b'）卟啉铁络合物或络合物的离子螯合物代替。
• PRODUCTION METHOD FOR (METH) ACRYLATE ARYL ESTER
  申请人：Mitsubishi Rayon Co., Ltd.

  公开号：EP2977367A1

  公开（公告）日：2016-01-27

  Provided is a low-tint (meth) acrylate aryl ester. This production method for (meth) acrylate aryl ester causes a specific hydroxyl group-containing aromatic compound and a (meth) acrylate anhydride to react, in the presence of a hindered phenol and a specific phosphite, and produces a (meth) acrylate aryl ester.

  本发明提供了一种低色调（甲基）丙烯酸酯芳基酯。 这种(甲基)丙烯酸酯芳基酯的生产方法是在受阻酚和特定亚磷酸酯的存在下，使特定的含羟基的芳香族化合物和(甲基)丙烯酸酯酸酐发生反应，生成(甲基)丙烯酸酯芳基酯。
• Fast internal conversion in 1-(dimethylamino)naphthalene: Effects of methoxy substitution on the naphthalene ring
  作者：Kazuyuki Takehira、Kengo Suzuki、Hiroshi Hiratsuka、Seiji Tobita

  DOI：10.1016/j.cplett.2005.07.038

  日期：2005.9

  Radiationless transitions of 1-(dimethylamino)naphthalene (1DMAN) and its 4-, 5-, 6-, and 7-methoxy derivatives having a twisted dimethylamino group in the Franck-Condon excited state are investigated by means of picosecond time-resolved fluorescence measurements. The fast internal conversion (IC) that has previously been observed for IDMAN, is also found for its 5- and 6-methoxy derivatives, while the IC rate decreases substantially in the 4- and 7-methoxy derivatives, showing that the fast IC is related to the proximity of the S-1 and S-2 states and also to the electronic structures of the S-1 and S-2 states. (c) 2005 Elsevier B.V. All rights reserved.
• IDO INHIBITORS AND THERAPEUTIC USES THEREOF
  申请人：Roehrig Ute

  公开号：US20110112282A1

  公开（公告）日：2011-05-12

  Compounds of formula (I), and pharmaceutically acceptable salts thereof, in which each compound is adapted to occupy the binding site of human IDO, which comprises a large hydrophobic pocket A and a second, proximal hydrophobic pocket B, the compound comprising at least one of the following elements: (i) a large hydrophobic fragment to substantially fill pocket A in the binding site of human IDO; (ii) an atom that can coordinate to the heme iron of human IDO, (iii) a positively charged group that can form a salt-bridge with the heme 7-propionate of the human IDO; (iv) a negatively charged group that can form a salt-bridge with Arg231 of the human IDO; (v) a hydrophobic group that can form van der Waals interactions with pocket B; and (vi) one or more substituents that can hydrogen bond to Ser167 and to Gly262, and as IDO inhibitors and their therapeutic use, eg in the treatment of cancer.