γ-bromo methyl-2-hexenoate | 91664-06-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: γ-bromo methyl-2-hexenoate
• 英文别名: (E)-methyl-4-bromohex-2-enoate；methyl 4-bromo-2-hexenoate；Methyl (e)-4-bromohex-2-enoate
• CAS: 91664-06-1
• 化学式: C₇H₁₁BrO₂
• 分子量: 207.067
• InChiKey: ITUFMJJVKOEQSC-SNAWJCMRSA-N

物化性质

• 沸点：
  216.1±23.0 °C(Predicted)
• 密度：
  1.338±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  γ-bromo methyl-2-hexenoate 以64%的产率得到
  参考文献：
  名称：

  ORSINI, F.;PELIZZONI, F., SYNTH. COMMUN., 1984, 14, N 2, 169-178

  摘要：

  DOI：
• 作为产物：
  描述：

  反式-2-己烯甲酯 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 以87%的产率得到γ-bromo methyl-2-hexenoate
  参考文献：
  名称：

  Orsini, F.; Pelizzoni, F., Synthetic Communications, 1984, vol. 14, # 2, p. 169 - 178

  摘要：

  DOI：

文献信息

• Cross-coupling of organomanganese derivatives of 3-sulfolenes with allyl and propargyl bromides; a simple synthesis of functionalized 1,3-dienes
  作者：A. N. Kasatkin、Yu. A. Prokopenko、A. M. Khabibov、G. A. Tolstikov

  DOI：10.1007/bf00699145

  日期：1994.1

  Reactions of organomanganese compounds RMnCl (R = 3-sulfolen-2-yl or 5-methyl-3-sulfolen-2-yl) with allyl or propargyl bromides afford the corresponding 2-substituted or 2,5-disubstituted 3-sulfolenes in high yields. Thermolysis of the cross-coupling products results in 1,3,6-trienes or 1,3-dien-6-ynes.
• HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：EP3784667A1

  公开（公告）日：2021-03-03
• TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF
  申请人：Hong Kong Baptist University

  公开号：US20160362691A1

  公开（公告）日：2016-12-15

  Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R 1 -R 7 , G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.
• US4254262A
  申请人：——

  公开号：US4254262A

  公开（公告）日：1981-03-03
• US9809822B2
  申请人：——

  公开号：US9809822B2

  公开（公告）日：2017-11-07