[(2S)-1-[(2S,5R)-5-[(1R)-1-(3,4-dimethoxyphenyl)ethyl]oxolan-2-yl]pentan-2-yl] acetate | 1027027-87-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2S)-1-[(2S,5R)-5-[(1R)-1-(3,4-dimethoxyphenyl)ethyl]oxolan-2-yl]pentan-2-yl] acetate
• CAS: 1027027-87-7
• 化学式: C₂₁H₃₂O₅
• 分子量: 364.482
• InChiKey: RNIDYGBHJGYXRN-GRGSLBFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [(2S)-1-[(2S,5R)-5-[(1R)-1-(3,4-dimethoxyphenyl)ethyl]oxolan-2-yl]pentan-2-yl] acetate 在 甲醇 、 ruthenium trichloride 、 sodium periodate 、 potassium carbonate 作用下， 以 四氯化碳 、 乙醚 、 水 、 乙腈 为溶剂， 生成 methyl (2S,3R,6S,8S)-3,6-epoxy-8-hydroxy-2-methylundecanoate
  参考文献：
  名称：

  Novel ether-ring transformation via a phenonium ion

  摘要：

  Upon treatment with CF3COOH at 70degreesC, trisubstituted-tetrahydropyrans. which were stereoselectively prepared from delta-lactones, were found to be converted into the corresponding 2,5-disubstituted-tetrahydrofurans stereospecifically via a phenonium ion. Furthermore, the stereocontrolled formal synthesis of paramycin 607 was achieved based on the ether-ring transformation. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01009-2
• 作为产物：
  描述：

  1-[(2S,5R,6R)-5-(3,4-Dimethoxy-phenyl)-6-methyl-tetrahydro-pyran-2-yl]-pent-4-en-2-ol 在 palladium on activated charcoal 吡啶 、 4-二甲氨基吡啶 、 氢气 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 [(2S)-1-[(2S,5R)-5-[(1R)-1-(3,4-dimethoxyphenyl)ethyl]oxolan-2-yl]pentan-2-yl] acetate
  参考文献：
  名称：

  Novel ether-ring transformation via a phenonium ion

  摘要：

  Upon treatment with CF3COOH at 70degreesC, trisubstituted-tetrahydropyrans. which were stereoselectively prepared from delta-lactones, were found to be converted into the corresponding 2,5-disubstituted-tetrahydrofurans stereospecifically via a phenonium ion. Furthermore, the stereocontrolled formal synthesis of paramycin 607 was achieved based on the ether-ring transformation. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01009-2