5′-bromo-3′,5-dimethyl-6-(2-methyl-4-(4-chloropyridin-3-yl)phenyl)-3,2′-bipyridine | 1359945-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5′-bromo-3′,5-dimethyl-6-(2-methyl-4-(4-chloropyridin-3-yl)phenyl)-3,2′-bipyridine
• 英文别名: 5'-bromo-3',5-dimethyl-6-[2-methyl-4-(6-chloro-pyridin-3-yl)phenyl]-3,2'-bipyridine；5-Bromo-2-[6-[4-(6-chloropyridin-3-yl)-2-methylphenyl]-5-methylpyridin-3-yl]-3-methylpyridine；5-bromo-2-[6-[4-(6-chloropyridin-3-yl)-2-methylphenyl]-5-methylpyridin-3-yl]-3-methylpyridine
• CAS: 1359945-12-2
• 化学式: C₂₄H₁₉BrClN₃
• 分子量: 464.792
• InChiKey: CQCLKTBVKJCMGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-5-吡啶硼酸 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium phosphate 、 四(三苯基膦)钯 、 sodium acetate 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 乙二醇二甲醚 、 水 为溶剂， 反应 60.0h， 生成 5′-bromo-3′,5-dimethyl-6-(2-methyl-4-(4-chloropyridin-3-yl)phenyl)-3,2′-bipyridine 、 5'-[2-methyl-4-(6-chloro-pyridin-3-yl)phenyl]-3',5-dimethyl-6-[2-methyl-4-(6-chloro-pyridin-3-yl)phenyl]-3,2'-bipyridine
  参考文献：
  名称：

  Synthesis of new linear poly(phenylpyridyl) chains

  摘要：

  This paper describes for the first time an efficient approach of Suzuki Miyaura cross-coupling reaction leading to new mixed linear unsymmetric phenylpyridyl chains (garlands). We have studied the synthesis of new phenylpyridyl boronic species and their reactivity with a dihalogenated bipyridine to obtain four and six unit phenylpyridines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.12.074

文献信息

• Synthesis of new linear poly(phenylpyridyl) chains
  作者：Serge Perato、Anne Sophie Voisin-Chiret、Jana Sopková-de Oliveira Santos、Rémi Legay、Hassan Oulyadi、Sylvain Rault

  DOI：10.1016/j.tet.2011.12.074

  日期：2012.2

  This paper describes for the first time an efficient approach of Suzuki Miyaura cross-coupling reaction leading to new mixed linear unsymmetric phenylpyridyl chains (garlands). We have studied the synthesis of new phenylpyridyl boronic species and their reactivity with a dihalogenated bipyridine to obtain four and six unit phenylpyridines. (C) 2011 Elsevier Ltd. All rights reserved.