2-(4-methoxy-3-nitrophenyl)-N,N-dipropylethylamine | 110925-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-methoxy-3-nitrophenyl)-N,N-dipropylethylamine
• 英文别名: N-[2-(4-methoxy-3-nitrophenyl)ethyl]-N-propylpropan-1-amine
• CAS: 110925-47-8
• 化学式: C₁₅H₂₄N₂O₃
• 分子量: 280.367
• InChiKey: NTIUCRUDOUDZCW-UHFFFAOYSA-N

物化性质

• 沸点：
  398.5±32.0 °C(Predicted)
• 密度：
  1.060±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-methoxy-3-nitrophenyl)-N,N-dipropylethylamine 在 镍 、 一水合肼 作用下， 以 乙醇 为溶剂， 生成 5-[2-(Dipropylamino)ethyl]-2-methoxyaniline
  参考文献：
  名称：

  含酚类生物等位基因的N，N-二-正丙啶胺类似物的合成及药理评价

  摘要：

  制备了一系列N，N-二-正丙基多巴胺（DPDA）的类似物，其中3-羟基被生物等位基团取代，并评估了D1-和D2-受体亲和力。3-甲烷-磺酰胺类似物（18）对D2受体的亲和力高于DPDA，对D2受体的选择性更高。3-甲酰胺衍生物（15）也保留了显着的D2亲和力。这两种化合物在麻醉的大鼠模型中均表现出体内心血管和肾脏特征，与选择性D2受体激动作用相一致。

  DOI：

  10.1002/jps.2600760515
• 作为产物：
  描述：

  甲基(4-甲氧基-3-硝基苯基)乙酸酯 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 、 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-(4-methoxy-3-nitrophenyl)-N,N-dipropylethylamine
  参考文献：
  名称：

  含酚类生物等位基因的N，N-二-正丙啶胺类似物的合成及药理评价

  摘要：

  制备了一系列N，N-二-正丙基多巴胺（DPDA）的类似物，其中3-羟基被生物等位基团取代，并评估了D1-和D2-受体亲和力。3-甲烷-磺酰胺类似物（18）对D2受体的亲和力高于DPDA，对D2受体的选择性更高。3-甲酰胺衍生物（15）也保留了显着的D2亲和力。这两种化合物在麻醉的大鼠模型中均表现出体内心血管和肾脏特征，与选择性D2受体激动作用相一致。

  DOI：

  10.1002/jps.2600760515

文献信息

• Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent: benzothiazol-2-one 7-ethylamines
  作者：Joseph Weinstock、Dimitri E. Gaitanopoulos、Orum D. Stringer、Robert G. Franz、J. Paul Hieble、Lewis B. Kinter、William A. Mann、Kathryn E. Flaim、George Gessner

  DOI：10.1021/jm00390a009

  日期：1987.7

  Our interest in identifying D-1 and D-2 dopamine receptor agonists that are not catechols led us to extend previous studies with oxindoles by investigating analogues of dopamine, N,N-dipropyldopamine, m-tyramine, N,N-dipropyl-m-tyramine, and epinine in which the m-hydroxyl is replaced by the NH portion of a thiazol-2-one, oxazol-2-one, or imidazol-2-one group fused to the 2,3-position. These compounds were evaluated for their affinity and agonist activity at D-1 and D-2 receptors by using in vitro assays. Replacement of the m-hydroxy in N,N-dipropyldopamine with the thiazol-2-one group resulted in a dramatic increase in D-2 receptor affinity and activity compared to that of N,N-dipropyldopamine itself or that of the corresponding oxindole, 1. The resulting compound, 7-hydroxy-4-[2-(di-n-propylamino)ethyl]benzothiazol-2(3H)-one (4), is the most potent D-2 receptor agonist reported to date in the field-stimulated rabbit ear artery (ED50 = 0.028 nM). The benzoxazol-2-one (6), benzimidazol-2-one (5), and isatin (51) analogues showed D-2 receptor agonist potency similar to that of 1. The des-7-hydroxyl analogue of 4 (21) also has enhanced D-2 receptor activity compared to that of the corresponding oxindole, 8. 7-Hydroxy-4-(2-aminoethyl)benzothiazol-2(3H)-one, 27, a non-catechol, has enhanced D-1 and D-2 receptor activity in vitro compared to that of the corresponding oxindole, 7. In vivo, 27 increased renal blood flow and decreased blood pressure in the dog. However, these effects were mediated primarily by D-2 receptor agonist activity. This may be a result of the D-1 partial agonist activity of 27 coupled with its potent D-2 receptor activity.
• Synthesis and Pharmacological Evaluation of N,N-di-n-Propyldopamine Congeners Containing Phenolic Bioisosteres
  作者：Robin D. Clark、Joan M. Caroon、Nancy E. Isaac、Deborah L. McClelland、Anton D. Michel、Toni A. Petty、Roberto P. Rosenkranz、L. David Waterbury

  DOI：10.1002/jps.2600760515

  日期：1987.5

  A series of analogues of N,N-di-n-propyldopamine (DPDA) in which the 3-hydroxyl group was replaced by bioisosteric groups was prepared and evaluated for D1- and D2-receptor affinity. The 3-methane-sulfonamide analogue (18) had a higher affinity for the D2 receptor than DPDA and was more selective for the D2 receptor. The 3-formamide derivative (15) also retained significant D2 affinity. Both of these

  制备了一系列N，N-二-正丙基多巴胺（DPDA）的类似物，其中3-羟基被生物等位基团取代，并评估了D1-和D2-受体亲和力。3-甲烷-磺酰胺类似物（18）对D2受体的亲和力高于DPDA，对D2受体的选择性更高。3-甲酰胺衍生物（15）也保留了显着的D2亲和力。这两种化合物在麻醉的大鼠模型中均表现出体内心血管和肾脏特征，与选择性D2受体激动作用相一致。