3,3',3"-[propane-1,2,3-triyltris(oxy)]tripropanoic acid | 56974-59-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,3',3"-[propane-1,2,3-triyltris(oxy)]tripropanoic acid
• 英文别名: 3,3',3"-[1,2,3-propanetriyltris(oxy)]tris-propanoic acid；3,3',3'-[propane-1,2,3-triyltris(oxy)]tripropanoic acid；1,2,3-Tris(2-carboxyethoxy)propane；3-[2,3-bis(2-carboxyethoxy)propoxy]propanoic acid
• CAS: 56974-59-5
• 化学式: C₁₂H₂₀O₉
• 分子量: 308.285
• InChiKey: WQFIRUGEYAEDNB-UHFFFAOYSA-N

物化性质

• 沸点：
  581.4±50.0 °C(Predicted)
• 密度：
  1.340±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  3,3',3"-[propane-1,2,3-triyltris(oxy)]tripropanoic acid 、 monoaqa-κO-hexakis(μ-acetato-κ²O)-dihydroxido-κ²O-di-μ₃-oxido-1:2:3κ⁶O-triangulo tritungsten(IV) 、 氨基三(羧乙氧基甲基)甲烷 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 0.25h， 以93 mg的产率得到(µ₃-3,3',3"-{aminomethylidynetris(methyleneoxy)}tripropanoato-1κ²O¹,O²:2κ²O^1',O³: 3κ²O^2',O^3')monoaqua-κO-dihydroxido-κ²O-di-µ₃-oxido-1:2:3κ⁶O-{µ₃-3,3',3"-[propane-1,2,3-triyltris(oxy)]tripropanoato-1κ²O¹,O²:2κ²O^1',O³:3κ²O^2',O^3'}triangulo tritungsten(IV)
  参考文献：
  名称：

  [EN] BIS TRIDENTATE W3O2 CLUSTERS FOR X-RAY IMAGING
  [FR] AGRÉGATS DE LIGANDS TRIDENTÉS BIS DE W3O2 POUR L'IMAGERIE PAR RAYONS X

  摘要：

  本发明描述了一种新型高稳定性的W3O2团簇，以及它们的制备方法，它们作为X射线造影剂的用途，以及作为三齿或四齿羧酸中间体的所需三齿配体资源。

  公开号：

  WO2013000970A1
• 作为产物：
  描述：

  tert-butyl 3-[2,3-bis(3-tert-butoxy-3-oxopropoxy)propoxy]propanoate 在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 3,3',3"-[propane-1,2,3-triyltris(oxy)]tripropanoic acid
  参考文献：
  名称：

  Bis Tridentate W3O2 Clusters for X-Ray imaging

  摘要：

  该发明描述了一类新型高稳定性的W3O2团簇，一种制备它们的方法，它们作为X射线造影剂的用途，以及作为三齿配体资源所需的三酸或四酸中间体。

  公开号：

  EP2540321A1

文献信息

• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT
  申请人：Malle Gerard

  公开号：US20100272660A1

  公开（公告）日：2010-10-28

  The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

  本申请涉及一种化妆品或药用组合物，包括由以下单体反应而得的聚缩酸酯：相对于聚缩酸酯的总重量，占10至30%的一种或多种含有3至6个羟基的多元醇；占30至80%的一种或多种线性、支链和/或环状、饱和或不饱和、非芳香族的单羧酸，含有6至32个碳原子；占聚缩酸酯总重量的1至40%的一种或多种多羧酸和/或多羧酸的环状酐和/或含有至少一个COOH基团的内酯；以及可选地占聚缩酸酯总重量的0.1至15%的一种或多种硅氧烷，具有羟基和/或羧基官能团。该申请还涉及使用所述组合物进行化妆处理的方法，以及如此定义的聚缩酸酯。
• Multi-arm single molecular weight polyethylene glycol, active derivative thereof, and preparation and application thereof
  申请人：JENKEM TECHNOLOGY CO., LTD. (TIANJIN)

  公开号：US11518728B2

  公开（公告）日：2022-12-06

  Being used for drug modification, the multi-arm single molecular weight polyethylene glycol and an active derivative thereof provided herein can effectively improve the solubility, stability, and immunogenicity of the drugs, improve the absorption of the drugs in vivo, prolong the half-life of the drugs, and increase bioavailability, enhance efficacy, and reduce toxic and side effects of the drugs. A gel formed from the active derivative of the multi-arm single molecular weight polyethylene glycol provided herein can be used for the preparation of controlled release drugs so as to prolong the action time of the drugs, thereby reducing the number of administrations and improving patient compliance.

  本发明提供的多臂单分子量聚乙二醇及其活性衍生物用于药物改性，可有效提高药物的溶解度、稳定性和免疫原性，改善药物的体内吸收，延长药物的半衰期，提高药物的生物利用度，增强药效，降低药物的毒副作用。本发明提供的多臂单分子量聚乙二醇活性衍生物形成的凝胶可用于制备控释药物，从而延长药物的作用时间，减少给药次数，提高患者的依从性。
• Antireflection film, polarizing plate and image display device
  申请人：Takada Katsuyuki

  公开号：US20110026126A1

  公开（公告）日：2011-02-03

  An antireflection film includes a support and a low refractive index layer formed from a composition for low refractive index layer containing (A) a polyfunctional fluorine-containing monomer having a polymerizable group and (B) a hydrophobilized conductive polymer composition containing a π-conjugated system conductive polymer and an anion group-containing polymer dopant, and a common logarithm log(SR) of a surface resistivity SR (Ω/sq) of a surface of the antireflection film on a side at which the low refractive index layer is provided is not more than 13.0.
• MULTI-ARM SINGLE MOLECULAR WEIGHT POLYETHYLENE GLYCOL, ACTIVE DERIVATIVE THEREOF, AND PREPARATION AND APPLICATION THEREOF
  申请人：JENKEM TECHNOLOGY CO., LTD. (TIANJIN)

  公开号：US20200131109A1

  公开（公告）日：2020-04-30

  Being used for drug modification, the multi-arm single molecular weight polyethylene glycol and an active derivative thereof provided herein can effectively improve the solubility, stability, and immunogenicity of the drugs, improve the absorption of the drugs in vivo, prolong the half-life of the drugs, and increase bioavailability, enhance efficacy, and reduce toxic and side effects of the drugs. A gel formed from the active derivative of the multi-arm single molecular weight polyethylene glycol provided herein can be used for the preparation of controlled release drugs so as to prolong the action time of the drugs, thereby reducing the number of administrations and improving patient compliance.