<3aS-<2E,3aα,4α(3S),5β,6aα>>-5--2(1H)-pentalenylidene>pentanoic acid methyl ester | 122047-91-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: <3aS-<2E,3aα,4α(3S),5β,6aα>>-5--2(1H)-pentalenylidene>pentanoic acid methyl ester
• 英文别名: [3aS-(2E,3aα,4α(3S),5β,6aα)]-5-{hexahydro-5-(tetrahydropyranyloxy)-4-[3-acetoxy-3-(2-indanyl)-1-propanyl]-2(1H)-pentalenylidene}pentanoic acid methyl ester；methyl (5E)-5-[(3aS,4R,5R,6aS)-4-[(3S)-3-acetyloxy-3-(2,3-dihydro-1H-inden-2-yl)propyl]-5-(oxan-2-yloxy)-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoate
• CAS: 122047-91-0
• 化学式: C₃₃H₄₆O₆
• 分子量: 538.725
• InChiKey: SNJKTIVWKNMVEP-XYBAUXSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.34
• 重原子数：
  39.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  <3aS-<2E,3aα,4α(3S),5β,6aα>>-5--2(1H)-pentalenylidene>pentanoic acid methyl ester 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 以99%的产率得到5-[(3aS,4R,5R,6aS)-4-((S)-3-Hydroxy-3-indan-2-yl-propyl)-5-(tetrahydro-pyran-2-yloxy)-hexahydro-pentalen-(2E)-ylidene]-pentanoic acid methyl ester
  参考文献：
  名称：

  Synthesis and biological activity of novel carbacyclins having bicyclic substituents on the .omega.-chain

  摘要：

  A number of carbacyclins having bicyclic substituents on the omega-chain have been synthesized and tested for antiplatelet aggregation activity in vitro (against collagen-induced aggregation of rat platelet), for reduction of systemic blood pressure in vivo (ability to reduce the blood pressure in anesthetized rat by iv injection), and for cytoprotective activity (protection against ethanol-induced rat gastric lesion). The most effective compound for each activity was [3aS-[2E,3a alpha,4 alpha (3R),5 beta,6a alpha]]-5-[hexahydro-5- hydroxy-4-[3-hydroxy-3-(2-indanyl)-1-propynyl]-2(1H)-pentalenylidene+ ++] pentanoic acid (compound 11a), while some 1,4-benzodioxan analogues had selectivity for organ-protective activity, and indan analogues showed selectivity in their antiaggregation activity.

  DOI：

  10.1021/jm00128a049
• 作为产物：
  描述：

  <3aS-<2E,3aα,4α(3R),5β,6aα>>-5--2(1H)-pentalenylidene>pentanoic acid methyl ester 在 sodium tetrahydroborate 、 18-冠醚-6 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 4.33h， 生成 <3aS-<2E,3aα,4α(3S),5β,6aα>>-5--2(1H)-pentalenylidene>pentanoic acid methyl ester
  参考文献：
  名称：

  Synthesis and biological activity of novel carbacyclins having bicyclic substituents on the .omega.-chain

  摘要：

  A number of carbacyclins having bicyclic substituents on the omega-chain have been synthesized and tested for antiplatelet aggregation activity in vitro (against collagen-induced aggregation of rat platelet), for reduction of systemic blood pressure in vivo (ability to reduce the blood pressure in anesthetized rat by iv injection), and for cytoprotective activity (protection against ethanol-induced rat gastric lesion). The most effective compound for each activity was [3aS-[2E,3a alpha,4 alpha (3R),5 beta,6a alpha]]-5-[hexahydro-5- hydroxy-4-[3-hydroxy-3-(2-indanyl)-1-propynyl]-2(1H)-pentalenylidene+ ++] pentanoic acid (compound 11a), while some 1,4-benzodioxan analogues had selectivity for organ-protective activity, and indan analogues showed selectivity in their antiaggregation activity.

  DOI：

  10.1021/jm00128a049

文献信息

• TSUYOSHI, TOMIYAMA;SHUICHI, WAKABAYASHI;MASAYUKI, YOKOTA, J. MED. CHEM., 32,(1989) N, C. 1988-1996
  作者：TSUYOSHI, TOMIYAMA、SHUICHI, WAKABAYASHI、MASAYUKI, YOKOTA

  DOI：——

  日期：——