5-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid | 40813-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 5-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid
• 英文别名: 5-Chlor-9,10-dioxo-9,10-dihydro-anthracen-1-carbonsaeure；5-Chlor-anthrachinon-carbonsaeure-(1)；5-Chlor-anthrachinon-1-carbonsaeure；5-Chloro-9,10-dioxoanthracene-1-carboxylic acid
• CAS: 40813-13-6
• 化学式: C₁₅H₇ClO₄
• 分子量: 286.671
• InChiKey: RBEPNNILWQKKFJ-UHFFFAOYSA-N

物化性质

• 熔点：
  306 °C (decomp)
• 沸点：
  551.5±50.0 °C(Predicted)
• 密度：
  1.561±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid 在 亚硝酸异戊酯 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2-Chlor-7-methoxycarbonyl-triptycen
  参考文献：
  名称：

  光学活性三萜。四、光学活性 2-或 5-取代的 7-羧基三萜的合成

  摘要：

  以蒽醌-1-羧酸 (I) 为原料，已经合成了 2-甲氧基-和 5-甲氧基-7-羧基三烯 (VIIa 和 VIIb)。用丁香碱对三苯甲酸进行光学拆分，得到 (+)-VIIa 和 (+)-VIIb。(+)-VIIa 的绝对构型通过与 (+)-2,5-二甲氧基-7-甲氧基羰基三苯甲基的化学相关性确定为 1R,6R。从 (+)-5-甲氧基-7-羧基三烯 (VIIb) 的 CD 光谱与 (+)-2-乙酰氧基-5-甲氧基-7-甲氧基羰基三烯 (XIIIb) 的 CD 光谱的比较来看，1R,6R 绝对构型为分配给 (+)-VIIb。(+)-2-Hydroxy-5-phenylazo-7-carboxytriptycene (XIIa) 衍生自 (+)-VIIa。(+)-2-氯-和(+)-5-氯-7-羧基三苯乙烯(XVIIIa和XVIIIb)已经由5-氯-和8-氯-1-羧基蒽醌(XIVa和XIVb)制备。

  DOI：

  10.1246/bcsj.46.611
• 作为产物：
  描述：

  7-chloro-aceanthrene-1,2-dione 在 铬酸 、 溶剂黄146 作用下， 生成 5-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid
  参考文献：
  名称：

  Butescu, Chemische Berichte, 1913, vol. 46, p. 213

  摘要：

  DOI：

文献信息

• Antimalarial Amino Alcohols II: Anthraceneaminoethanols and Anthraceneaminopropanols (1‐ and 9‐Substituted)
  作者：J.T. Traxler、M.J. Moats、E.P. Lira、C.W. Huffman

  DOI：10.1002/jps.2600641207

  日期：1975.12

  The syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. These compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. The antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the

  描述了七个具有一个，两个或三个另外的取代基的蒽氨基醇的合成。这些化合物包括由取代的蒽醌或由10-氯-9-蒽醛制得的三种1-氨基乙醇，两种9-氨基乙醇和两种9-氨基丙醇。根据先前发表的工作讨论了这些化合物的抗疟活性以及初步的构效关系。
• 115. The constitution of the chlorination products of benzanthrone
  作者：R. S. Cahn、W. O. Jones、J. L. Simonsen

  DOI：10.1039/jr9330000444

  日期：——
• Heilbron; Heslop; Irving, Journal of the Chemical Society, 1936, p. 784
  作者：Heilbron、Heslop、Irving

  DOI：——

  日期：——
• Maki, The journal of the Society of Chemical Industry, Japan. Supplemental binding., vol. 38, p. 633 B
  作者：Maki

  DOI：——

  日期：——
• Gender and pain upon movement are associated with the requirements for postoperative patient-controllediv analgesia: a prospective survey of 2,298 Chinese patients
  作者：Yuan-Yi Chia、Lok-Hi Chow、Chun-Chieh Hung、Kang Liu、Luo-Ping Ger、Pei-Ning Wang

  DOI：10.1007/bf03020523

  日期：2002.3

  Purpose: To investigate prospectively the influence of patient characteristics upon, and the association of postoperative measurements with, the requirements for postoperative morphine and the assessment of resting pain and pain upon movement in Chinese patients.Methods: From January 1998 to December 1999, patients receiving patient-controlled iv morphine subsequent to general anesthesia and surgery at our institute (Kaohsiung Veterans General Hospital), were enrolled in the study. Demographic data (such as gender, age, weight, height and education level) and postoperative measurements, including pain scores at rest or during movement, sedation scores and morphine consumption, were recorded.Results: In total 2,298 patients were recruited. Females consumed significantly less morphine via patient-controlled analgesia (PCA) in the first three postoperative days than was the case for males (P < 0.05). Gender was the strongest predictor for postoperative morphine requirements. Postoperative pain upon movement was another effective predictor for morphine requirement (P < 0.05). Age, body height, body weight, education and operation sites were not associated with morphine consumption.Conclusion: Gender and postoperative pain upon movement are the major factors influencing morphine requirement for patient postoperative days in Chinese patients.