5-[2-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)pyridin-5-ylmethyl]thiazolidine-2,4-dione | 107187-42-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-[2-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)pyridin-5-ylmethyl]thiazolidine-2,4-dione
• 英文别名: 5-[[6-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]pyridin-3-yl]methyl]-1,3-thiazolidine-2,4-dione
• CAS: 107187-42-8
• 化学式: C₂₃H₂₆N₂O₅S
• 分子量: 442.536
• InChiKey: MVCYKZSOWMLSQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-[2-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)pyridin-5-ylmethyl]thiazolidine-2,4-dione 在 间氯过氧苯甲酸 作用下， 以 甲醇 、 氯仿 为溶剂， 生成
  参考文献：
  名称：

  Studies on some glitazones having pyridine as the linker unit

  摘要：

  Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.11.027
• 作为产物：
  描述：

  奎诺二甲基丙烯酸酯 在 palladium on activated charcoal 、 镍 lithium aluminium tetrahydride 、 甲酸 、 硫酸 、 氢气 、 哌啶乙酸盐 、 sodium hydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 、 甲苯 、 苯 为溶剂， 反应 64.0h， 生成 5-[2-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)pyridin-5-ylmethyl]thiazolidine-2,4-dione
  参考文献：
  名称：

  Studies on some glitazones having pyridine as the linker unit

  摘要：

  Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.11.027

文献信息

• Thiazolidine derivatives, their preparation and use
  申请人：Sankyo Company, Limited

  公开号：US05104888A1

  公开（公告）日：1992-04-14

  Compounds of formula (I): ##STR1## (in which R.sup.1 -R.sup.7 are hydrogen or various organic groups, n is 1-10, Ar is an aromatic group, U is CH.sub.2 or a carbon atom doubly bonded to either one of its adjacent carbons, and W is >CH.sub.2, >C.dbd.O, >CHOH, >C.dbd.NOH or various derivatives thereof) have the ability to lower the levels of blood lipid peroxides and blood sugars and to inhibit the activity of aldose reductase; they may be used therapeutically for these purposes.

  公式(I)的化合物：##STR1##（其中R.sup.1 -R.sup.7是氢或各种有机基团，n是1-10，Ar是芳香族基团，U是CH.sub.2或一个碳原子与任一相邻的碳原子双键连接，W是>CH.sub.2，>C.dbd.O，>CHOH，>C.dbd.NOH或其各种衍生物）具有降低血脂过氧化物和血糖水平以及抑制醛糖还原酶活性的能力；它们可以用于这些目的的治疗。
• US5104888A
  申请人：——

  公开号：US5104888A

  公开（公告）日：1992-04-14
• Studies on some glitazones having pyridine as the linker unit
  作者：U Ramachandran

  DOI：10.1016/j.bmc.2003.11.027

  日期：2004.2.15

  Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated. (C) 2003 Elsevier Ltd. All rights reserved.