<6-(Methoxymethoxy)-2,5,7,8-tetramethylchroman-2-yl>methanol | 107188-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: <6-(Methoxymethoxy)-2,5,7,8-tetramethylchroman-2-yl>methanol
• 英文别名: [6-(methoxymethoxy)-2,5,7,8-tetramethylchroman-2-yl]methanol；2-hydroxymethyl-6-methoxymethoxy-2,5,7,8-tetramethylchroman；6-(Methoxymethoxy)-2,5,7,8-tetramethylchroman-2-ylmethanol；[6-(methoxymethoxy)-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl]methanol
• CAS: 107188-55-6
• 化学式: C₁₆H₂₄O₄
• 分子量: 280.364
• InChiKey: JQGLXFODQGLGTH-UHFFFAOYSA-N

物化性质

• 熔点：
  56-59 °C
• 沸点：
  408.1±45.0 °C(Predicted)
• 密度：
  1.078±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  <6-(Methoxymethoxy)-2,5,7,8-tetramethylchroman-2-yl>methanol 在 palladium on activated charcoal 吡啶 、 copper(I) oxide 、 盐酸 、 硫酸 、 氢气 、 sodium hydride 、 溶剂黄146 、 sodium nitrite 作用下， 以 甲醇 、 苯 为溶剂， 120.0 ℃ 、380.0 kPa 条件下， 反应 19.34h， 生成 曲格列酮
  参考文献：
  名称：

  Studies on hindered phenols and analogs. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation

  摘要：

  A series of hindered phenols were investigated as hypolipidemic and/or hypoglycemic agents with ability to inhibit lipid peroxidation. 1,3-Benzoxathioles (9 and 22), phenoxypentanoic acid (34), phenoxypentanol (35a), phenoxynonanol (35b), phenylchloropropionic acid having a chromanyl group (25), and a thiazolidine compound (27) derived from 25, all having a hindered phenol group, were prepared and examined. Compound 27 showed the expected biological properties in vivo and in vitro without any liver weight increase. Biological activities of the analogous thiazolidine compounds, 43-58, were compared. Thus, (+/-)-5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]- benzyl]-2,4-thiazolidinedione (27) (CS-045) was found to have all of our expected properties and was selected as a candidate for further development as a hypoglycemic and hypolipidemic agent.

  DOI：

  10.1021/jm00122a022
• 作为产物：
  描述：

  奎诺二甲基丙烯酸酯 在 lithium aluminium tetrahydride 、 sodium hydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 <6-(Methoxymethoxy)-2,5,7,8-tetramethylchroman-2-yl>methanol
  参考文献：
  名称：

  Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

  摘要：

  A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.10.006

文献信息

• Thiazolidine derivatives, their preparation and use
  申请人：Sankyo Company, Limited

  公开号：US05104888A1

  公开（公告）日：1992-04-14

  Compounds of formula (I): ##STR1## (in which R.sup.1 -R.sup.7 are hydrogen or various organic groups, n is 1-10, Ar is an aromatic group, U is CH.sub.2 or a carbon atom doubly bonded to either one of its adjacent carbons, and W is >CH.sub.2, >C.dbd.O, >CHOH, >C.dbd.NOH or various derivatives thereof) have the ability to lower the levels of blood lipid peroxides and blood sugars and to inhibit the activity of aldose reductase; they may be used therapeutically for these purposes.

  公式(I)的化合物：##STR1##（其中R.sup.1 -R.sup.7是氢或各种有机基团，n是1-10，Ar是芳香族基团，U是CH.sub.2或一个碳原子与任一相邻的碳原子双键连接，W是>CH.sub.2，>C.dbd.O，>CHOH，>C.dbd.NOH或其各种衍生物）具有降低血脂过氧化物和血糖水平以及抑制醛糖还原酶活性的能力；它们可以用于这些目的的治疗。
• Thiazolidine derivatives, their preparation and compositions containing
  申请人：Sankyo Company Limited

  公开号：US04572912A1

  公开（公告）日：1986-02-25

  The compounds of formula (I): ##STR1## [in which: R.sup.1 and R.sup.2 are the same or different and each represents hydrogen or C.sub.1 -C.sub.5 alkyl; R.sup.3 represents hydrogen, an acyl group, a (C.sub.1 -C.sub.6 alkoxy)carbonyl group or an aralkyloxycarbonyl group; R.sup.4 and R.sup.5 are the same or different and each represents hydrogen, C.sub.1 -C.sub.5 alkyl or C.sub.1 -C.sub.5 alkoxy, or R.sup.4 and R.sup.5 together represent a C.sub.1 14 C.sub.4 alkylenedioxy group; n is 1, 2 or 3; W represents the --CH.sub.2 --, >CO or >CH--OR.sup.6 group (in which R.sup.6 represents any one of the atoms or groups defined for R.sup.3 and may be the same as or different from R.sup.3); and Y and Z are the same or different and each represents oxygen or imino] and pharmaceutically acceptable salts thereof have various valuable therapeutic effects on the blood system and may be prepared by a process which includes reacting a corresponding halopropionic acid derivative with thiourea.

  化合物的化学式（I）：##STR1## [其中：R.sup.1和R.sup.2相同或不同，每个代表氢或C.sub.1 -C.sub.5烷基；R.sup.3代表氢，酰基，（C.sub.1 -C.sub.6烷氧）羰基或芳基氧羰基；R.sup.4和R.sup.5相同或不同，每个代表氢，C.sub.1 -C.sub.5烷基或C.sub.1 -C.sub.5烷氧，或R.sup.4和R.sup.5一起代表C.sub.1 14 C.sub.4烷二氧基基团；n为1、2或3；W代表--CH.sub.2 --，>CO或>CH--OR.sup.6基团（其中R.sup.6代表R.sup.3定义的任一原子或基团，可能与R.sup.3相同或不同）；Y和Z相同或不同，每个代表氧或亚胺]及其药学上可接受的盐对血液系统具有各种有价值的治疗效果，并可通过将相应的卤代丙酸衍生物与硫脲反应制备。
• Studies on some glitazones having pyridine as the linker unit
  作者：U Ramachandran

  DOI：10.1016/j.bmc.2003.11.027

  日期：2004.2.15

  Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated. (C) 2003 Elsevier Ltd. All rights reserved.
• Thiazolidine derivatives, their preparation and compositions containing them
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0139421B1

  公开（公告）日：1988-04-27
• JOSIOKA, TAKAO;KITADZAVA, EHJITI;KURUMADA, TOMOYUKI;YAMADZAKI, MITSURO;XA+
  作者：JOSIOKA, TAKAO、KITADZAVA, EHJITI、KURUMADA, TOMOYUKI、YAMADZAKI, MITSURO、XA+

  DOI：——

  日期：——