4,4'-bi(1-carboxylanthraquinone) | 854209-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 4,4'-bi(1-carboxylanthraquinone)
• 英文别名: 9,10,9',10'-tetraoxo-9,10,9',10'-tetrahydro-[1,1']bianthryl-4,4'-dicarboxylic acid；9,10,9',10'-Tetraoxo-9,10,9',10'-tetrahydro-[1,1']bianthryl-4,4'-dicarbonsaeure
• CAS: 854209-79-3
• 化学式: C₃₀H₁₄O₈
• 分子量: 502.436
• InChiKey: KEYPQHWVVKPAMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  38.0
• 可旋转键数：
  3.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  142.88
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  4,4'-bi(1-carboxylanthraquinone) 在 氯化亚砜 作用下， 生成 9.10.9'.10'-tetraoxo-9.10.9'.10'-tetrahydro-[1.1']bianthryl-dicarboxylic acid-(4.4')-di-((1R)-menthyl ester)
  参考文献：
  名称：

  Regional blood flows are affected differently by PEEP when the abdomen is open or closed: An experimental rabbit model

  摘要：

  Objective: The study of induced circulatory changes requires simultaneous assessment of multiple regional circulations because of interactions and compensatory mechanisms. Positive end expiratory pressure mechanical ventilation (PEEP) is known to cause marked, and potentially deleterious, cardiovascular changes. Our aim was to use a comprehensive approach to assess PEEP-induced circulatory changes in open vs closed abdomen animals,Material and methods: In the anesthetized rabbit, we used implantable Doppler micro-probes to measure blood flow simultaneously in the ascending aorta, inferior vena cava, portal vein, hepatic artery common carotid artery, and renal artery, We studied spontaneously breathing animals (Group A), and open (Group B) and closed abdomen (Group C) animals mechanically ventilated at 0 (ZEEP) and 12 cm H2O PEEPResults: In Group A, all biological and hemodynamic variables remained unchanged for three hours at the end of the surgical procedure. In Groups B and C, ZEEP produced no significant hemodynamic change. PEEP induced a decrease in carotid, hepatic, and renal artery blood flow in Groups B and C, a decrease in heart rate and mean arterial blood pressure in Group B, and a decrease in aorta blood flow in Group C.Conclusions: These experimental results demonstrate the usefulness of the comprehensive approach of circulatory changes, and confirm that PEEP may have deleterious effects on regional blood flow, even without significant change in cardiac output, especially when the abdomen is open.

  DOI：

  10.1007/bf03020532
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 辛可尼丁 作用下， 生成 4,4'-bi(1-carboxylanthraquinone)
  参考文献：
  名称：

  401.对称的二蒽。第四部分

  摘要：

  DOI：

  10.1039/jr9500001963

文献信息

• 330. Kationoid reactivity of aromatic compounds. Part VII. The composition of the dimesobenzanthronyl formed by the action of alkaline condensing agents on mesobenzanthrone
  作者：W. Bradley、G. V. Jadhav

  DOI：10.1039/jr9480001622

  日期：——