(R)-2-aminoxy-4-methylvaleric acid | 42038-71-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-2-aminoxy-4-methylvaleric acid
• 英文别名: 2-aminooxy-4-methyl-pentanoic acid；2(R)-aminoxyisocaproic acid；D-α-Aminooxy-γ-methyl-valeriansaeure；R-2-Amino-oxy-4-methylvaleriansaeure；(2R)-2-aminooxy-4-methylpentanoic acid
• CAS: 42038-71-1
• 化学式: C₆H₁₃NO₃
• 分子量: 147.174
• InChiKey: FOLNEXIKZNWGRI-RXMQYKEDSA-N

物化性质

• 沸点：
  280.0±23.0 °C(Predicted)
• 密度：
  1.106±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl-2-[2-(6-morpholin-4-yl-3,4-dihydro-2H-naphthalen-1-ylidene)-ethyl]-cyclopentane-1,3-dione 、 (R)-2-aminoxy-4-methylvaleric acid 生成 4-methyl-2-(13-methyl-3-morpholin-4-yl-6,7,11,12,13,16-hexahydro-cyclopenta[a]phenanthren-17-ylideneaminooxy)-pentanoic acid methyl ester
  参考文献：
  名称：

  19-类固醇的不对称合成

  摘要：

  DOI：

  10.1016/s0040-4039(01)96250-1
• 作为产物：
  描述：

  Ethyl-D-α-Ethoxycarbonylaminooxy-γ-methyl-valerat 在 盐酸 作用下， 生成 (R)-2-aminoxy-4-methylvaleric acid
  参考文献：
  名称：

  Liberek,B.; Cupryszak,C., Roczniki Chemii, 1971, vol. 45, p. 677 - 679

  摘要：

  DOI：

文献信息

• Stereospecific nitromethane conjugate addition to 4-oxygenated-2-substituted-cyclo pent-2-enones: a simple approach to prostaglandins
  作者：P.G. Baraldi、A. Barco、S. Benetti、G.P. Pollini、D. Simoni、V. Zanirato

  DOI：10.1016/s0040-4020(01)86909-x

  日期：1987.1

  nitromethane conjugate addition to 2-cyclo-pentenones bearing a 4-oxygenated function has been illustrated through a short and practical synthesis of the Corey aldehyde, a key intermediate in prostaglandin synthesis, in both racemic and optically active form. A new synthesis of PGF2α featuring the introduction of the ω-chain via [3+2] cycloaddition has been also described.

  通过短而实用的外消旋和旋光形式合成Corey醛（Cores醛是前列腺素合成的关键中间体），说明了硝基甲烷共轭物加成物与带有4-氧合功能的2-环戊烯酮的相容性。PGF的新合成2α设有经由[3 + 2]环加成已经描述也引入ω链的。
• 7-{3-Hydroxy-2.beta.-[4-hydroxy-4-(lower
  申请人：G. D. Searle & Co.

  公开号：US04087621A1

  公开（公告）日：1978-05-02

  7-3-Hydroxy-2.beta.-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1.alpha.-yl}hept-5-cis-enoic acids, displaying valuable pharmacological properties, e.g., gastric anti-secretory, are produced by the reaction of 7-(3-oxygenated-5-oxocyclopent-1-en-1-yl)hept-5-cis-enoic acid or ester with the appropriate organometallic reagent.

  7-3-羟基-2.beta.-[4-羟基-4-(较低烷基)-反-1-辛烯-1-基]-5-氧代环戊-1.alpha.-基}庚-5-顺-烯酸，具有有价值的药理特性，如胃抑酸作用，是通过7-(3-氧代-5-氧代环戊-1-烯-1-基)庚-5-顺-烯酸或酯与适当的有机金属试剂反应而产生的。
• Processes for the preparations of optically active cyclopentenones and cyclopentenones prepared therefrom
  申请人：Yeh Yu-Chih

  公开号：US20070166809A1

  公开（公告）日：2007-07-19

  The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.

  本发明涉及一种制备(R)-1式光学活性环戊酮的新工艺，其可用于制备前列腺素及其类似物。该发明还涉及从该工艺中制备的新型环戊酮。
• Process for the preparation of optically active cyclopentenones
  申请人：Chirogate International Inc.

  公开号：EP1811037A1

  公开（公告）日：2007-07-25

  The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.

  本发明涉及制备具有光学活性的式(R)-1环戊烯酮的新工艺，该工艺可用于制备前列腺素及其类似物。 本发明还涉及由该工艺制备的新型环戊烯酮。
• Optically active cyclopentenones for use in the peparation of prostaglandins
  申请人：Wei, Shih-Yi

  公开号：EP1811037B1

  公开（公告）日：2011-02-23