methyl 2-(2-hydroxybenzylamino)propanoate | 1258508-73-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-(2-hydroxybenzylamino)propanoate
• 英文别名: Methyl 2-[(2-hydroxyphenyl)methylamino]propanoate
• CAS: 1258508-73-4
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: GFYYFTHUQFUFNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  potassium tetrachloroplatinate(II) 、 methyl 2-(2-hydroxybenzylamino)propanoate 以 甲醇 、 水 为溶剂， 反应 24.0h， 以78.9%的产率得到Pt[methyl 2-(2-hydroxybenzylamino)propanoate]Cl
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with reduced amino acid ester Schiff-bases as ligands

  摘要：

  A series of platinum(II) complexes with reduced amino acid esters Schiff-bases as ligands were prepared as potential anticancer agents and characterized by NMR, IR spectroscopy, elemental analysis and molar conductivity. These compounds were tested for their stability and DNA interaction with salmon sperm DNA by ultraviolet spectrum. The cytotoxicities of these complexes were validated against HL-60, BGC-823, Hela, and HepG2 cell lines by the MTT test. The complexes 5e and 5f exhibited better cytotoxic activity than cisplatin against HepG2 and BGC-823 cell lines, respectively. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.04.036
• 作为产物：
  描述：

  水杨醛 在 sodium tetrahydroborate 、 magnesium sulfate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 40.0h， 生成 methyl 2-(2-hydroxybenzylamino)propanoate
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with reduced amino acid ester Schiff-bases as ligands

  摘要：

  A series of platinum(II) complexes with reduced amino acid esters Schiff-bases as ligands were prepared as potential anticancer agents and characterized by NMR, IR spectroscopy, elemental analysis and molar conductivity. These compounds were tested for their stability and DNA interaction with salmon sperm DNA by ultraviolet spectrum. The cytotoxicities of these complexes were validated against HL-60, BGC-823, Hela, and HepG2 cell lines by the MTT test. The complexes 5e and 5f exhibited better cytotoxic activity than cisplatin against HepG2 and BGC-823 cell lines, respectively. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.04.036

文献信息

• Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with reduced amino acid ester Schiff-bases as ligands
  作者：Li-Jun Li、Bin Fu、Yu Qiao、Cheng Wang、Ying-Ying Huang、Chuan-Chuan Liu、Chao Tian、Jian-Long Du

  DOI：10.1016/j.ica.2014.04.036

  日期：2014.8

  A series of platinum(II) complexes with reduced amino acid esters Schiff-bases as ligands were prepared as potential anticancer agents and characterized by NMR, IR spectroscopy, elemental analysis and molar conductivity. These compounds were tested for their stability and DNA interaction with salmon sperm DNA by ultraviolet spectrum. The cytotoxicities of these complexes were validated against HL-60, BGC-823, Hela, and HepG2 cell lines by the MTT test. The complexes 5e and 5f exhibited better cytotoxic activity than cisplatin against HepG2 and BGC-823 cell lines, respectively. (C) 2014 Elsevier B.V. All rights reserved.