Tert-butyl-diphenyl-[2-[4-(3-phenylmethoxypropyl)-1,3-oxazol-2-yl]pent-4-ynoxy]silane | 950697-18-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl-diphenyl-[2-[4-(3-phenylmethoxypropyl)-1,3-oxazol-2-yl]pent-4-ynoxy]silane
• 英文别名: tert-butyl-diphenyl-[2-[4-(3-phenylmethoxypropyl)-1,3-oxazol-2-yl]pent-4-ynoxy]silane
• CAS: 950697-18-4
• 化学式: C₃₄H₃₉NO₃Si
• 分子量: 537.774
• InChiKey: NIYQXCJNZRRJKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.51
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tert-butyl-diphenyl-[2-[4-(3-phenylmethoxypropyl)-1,3-oxazol-2-yl]pent-4-ynoxy]silane 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 (E)-N-((2E,6Z)-11-(4-(3-(benzyloxy)propyl)oxazol-2-yl)-12-hydroxydodeca-2,6-dien-8-yn-1-yl)-3-methoxy-N-methylbut-2-enamide
  参考文献：
  名称：

  Synthesis of the C9–C29 fragments of ajudazols A and B

  摘要：

  The syntheses of both C9-C29 fragments 3 and 4 of the myxobacteria metabolites ajudazols A (1) and B (2) are described. The key steps were a cyclodehydration to form the oxazole, Sonogashira coupling to form the C18-C19 bond and a P-2 Ni mediated partial alkyne hydrogenation to install the C17-C18 Z-alkene. The C15 alkene in the ajudazol A fragnient 3 was introduced in the final steps by elimination of the corresponding primary alcohol. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.06.072
• 作为产物：
  描述：

  (+/-)-5-benzyloxy-1-tert-butyldimethylsilyloxy-2-pentanol 在 吡啶 、 camphor-10-sulfonic acid 、 二甲基氨基丙基乙基碳酰胺 、 1-羟基苯并三唑 、 戴斯-马丁氧化剂 、 甲基磺酰氯 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 Tert-butyl-diphenyl-[2-[4-(3-phenylmethoxypropyl)-1,3-oxazol-2-yl]pent-4-ynoxy]silane
  参考文献：
  名称：

  Synthesis of the C9–C29 fragments of ajudazols A and B

  摘要：

  The syntheses of both C9-C29 fragments 3 and 4 of the myxobacteria metabolites ajudazols A (1) and B (2) are described. The key steps were a cyclodehydration to form the oxazole, Sonogashira coupling to form the C18-C19 bond and a P-2 Ni mediated partial alkyne hydrogenation to install the C17-C18 Z-alkene. The C15 alkene in the ajudazol A fragnient 3 was introduced in the final steps by elimination of the corresponding primary alcohol. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.06.072

文献信息

• Synthesis of the C9–C29 fragments of ajudazols A and B
  作者：Danny Ganame、Tim Quach、Charlotte Poole、Mark A. Rizzacasa

  DOI：10.1016/j.tetlet.2007.06.072

  日期：2007.8

  The syntheses of both C9-C29 fragments 3 and 4 of the myxobacteria metabolites ajudazols A (1) and B (2) are described. The key steps were a cyclodehydration to form the oxazole, Sonogashira coupling to form the C18-C19 bond and a P-2 Ni mediated partial alkyne hydrogenation to install the C17-C18 Z-alkene. The C15 alkene in the ajudazol A fragnient 3 was introduced in the final steps by elimination of the corresponding primary alcohol. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.