ethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethylcarbamate | 1233483-88-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethylcarbamate
• 英文别名: ethyl N-[2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethyl]carbamate
• CAS: 1233483-88-9
• 化学式: C₂₀H₂₅NO₅
• 分子量: 359.422
• InChiKey: MAQHOGRTGUXMOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethylcarbamate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-N-methylethanamine
  参考文献：
  名称：

  Efficient Syntheses of (±)-Cherylline and Latifine Dimethyl Ether

  摘要：

  A concise route for the syntheses of (+/-)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet-Spengler cyclization.

  DOI：

  10.1080/00397910903109859
• 作为产物：
  描述：

  2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanamine 、 氯甲酸乙酯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 ethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethylcarbamate
  参考文献：
  名称：

  Efficient Syntheses of (±)-Cherylline and Latifine Dimethyl Ether

  摘要：

  A concise route for the syntheses of (+/-)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet-Spengler cyclization.

  DOI：

  10.1080/00397910903109859

文献信息

• Efficient Syntheses of (±)-Cherylline and Latifine Dimethyl Ether
  作者：A. Sanjeev Kumar、Samir Ghosh、R. Soundararajan、G. N. Mehta

  DOI：10.1080/00397910903109859

  日期：2010.5.11

  A concise route for the syntheses of (+/-)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet-Spengler cyclization.