N-allyl-N'-[2]pyridyl-urea | 161112-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-allyl-N'-[2]pyridyl-urea
• 英文别名: N-Allyl-N'-[2]pyridyl-harnstoff；1-Prop-2-enyl-3-pyridin-2-ylurea
• CAS: 161112-32-9
• 化学式: C₉H₁₁N₃O
• mdl: MFCD00649566
• 分子量: 177.206
• InChiKey: IGLMPQURKZPJGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  54
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲醇 、 N-allyl-N'-[2]pyridyl-urea 、 mercury(II) diacetate 在 溶剂黄146 作用下， 生成 2-methoxy-3-(N'-[2]pyridyl-ureido)-propylmercury (1+); (+/-)-N-(3-chloromercurio-2-methoxy-propyl)-N'-[2]pyridyl-urea
  参考文献：
  名称：

  Mercuration products of 1-pyridyl-3-allylureas

  摘要：

  公开号：

  US02863863A1
• 作为产物：
  描述：

  1-烯丙基-3-(2-吡啶)硫代脲 在 sodium hydroxide 、 lead acetate 作用下， 生成 N-allyl-N'-[2]pyridyl-urea
  参考文献：
  名称：

  Über einige Derivate des 2-Amino-pyridins

  摘要：

  DOI：

  10.1002/ardp.19342720508

文献信息

• [EN] NOVEL PIPERIDINE DERIVATIVES<br/>[FR] DERIVES DE PIPERIDINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004099180A1

  公开（公告）日：2004-11-18

  The invention relates to novel piperidine derivatives and related compounds of General Formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists, in particular their use as urotensin II antagonists.

  该发明涉及新型哌啶衍生物和一般式I相关化合物，以及它们作为药物组合物制备中的活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有其中一种或多种化合物的药物组合物，特别是它们作为神经激素拮抗剂的用途，特别是它们作为尿苷Ⅱ拮抗剂的用途。
• [EN] PIPERAZINE-ALKYL-UREIDO DERIVATIVES<br/>[FR] DERIVES DE PIPERAZINE-ALKYLE-UREIDO
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004099179A1

  公开（公告）日：2004-11-18

  The invention relates to novel piperazine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists. (I)

  该发明涉及新型哌嗪衍生物和相关化合物，以及它们作为制备药物组成的活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有其中一种或多种化合物的药物组成，尤其是它们作为神经荷尔蒙拮抗剂的用途。
• [EN] PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS<br/>[FR] DERIVES DE PYRIDINE ET LEUR UTILISATION COMME ANTAGONISTES DE L'UROTENSINE II
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2005030209A1

  公开（公告）日：2005-04-07

  The invention relates to novel pyridine derivatives of formula 1 and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and their use as neurohormonal antagonists, especially as urotensin II inhibitors.

  该发明涉及公式1的新型吡啶衍生物和相关化合物，以及它们作为药物组成物中的活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组成物，以及它们作为神经荷尔蒙拮抗剂的用途，特别是作为尿泉素II抑制剂。
• [EN] 4-(PIPERIDYL- AND PYRROLIDYL-ALKYL-UREIDO) -QUINOLINES AS UROTENSIN II RECEPTOR ANTAGONISTS<br/>[FR] NOUVEAUX DERIVES DE QUINOLEINES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003048154A1

  公开（公告）日：2003-06-12

  The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

  本发明涉及新型的1-吡啶-4-基脲衍生物及相关化合物，以及它们作为制备药物组合物的活性成分的用途。本发明还涉及相关方面，包括制备这些化合物的过程，含有这些化合物中的一个或多个的药物组合物，特别是它们作为神经荷尔蒙拮抗剂的用途。
• 1-Pyridin-4-yl-urea derivatives
  申请人：Aissaoui Hamed

  公开号：US20060094716A1

  公开（公告）日：2006-05-04

  The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

  本发明涉及新型的1-吡啶-4-基脲衍生物及其相关化合物，以及将其用作制备药物组合物中的活性成分。本发明还涉及相关方面，包括制备该化合物的过程，含有其中一个或多个化合物的药物组合物，特别是它们作为神经激素拮抗剂的用途。