2-<amino>pyridine | 88932-67-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-<amino>pyridine
• 英文别名: 2-{[N-(tert-butyloxycarbonyl)-L-phenylalanyl]amino}pyridine；tert-butyl N-[(2S)-1-oxo-3-phenyl-1-(pyridin-2-ylamino)propan-2-yl]carbamate
• CAS: 88932-67-6
• 化学式: C₁₉H₂₃N₃O₃
• 分子量: 341.41
• InChiKey: HJHAPMLKFPVEIY-HNNXBMFYSA-N

物化性质

• 沸点：
  578.6±50.0 °C(Predicted)
• 密度：
  1.184±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  80.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-<amino>pyridine 在 三氟乙酸 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 反应 2.0h， 生成 (S)-2-amino-3-phenyl-N-(pyridin-2-yl)propanamide
  参考文献：
  名称：

  基于简单双齿配体的伯胺金属路易斯酸双功能催化剂：直接不对称醛醇缩合反应。

  摘要：

  开发了一种新型的基于双齿配体的伯胺金属路易斯酸双功能催化剂。这些催化剂在催化具有优异立体选择性的酮类的直接不对称醛醇缩合反应中非常高效。醛醇缩合反应需要低的催化剂负载量（2.5mol％），并且与水相容。

  DOI：

  10.1039/c0cc00917b
• 作为产物：
  描述：

  BOC-L-苯丙氨酸 在 吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 2-<amino>pyridine
  参考文献：
  名称：

  Synthesis of pyridine derivatives of L-phenylalanine as antisickling reagents

  摘要：

  Several bicyclic agents composed of L-phenylalanine coupled to various pyridines were synthesized: 2-, 3-, and 4-(L- phenylalanylamino )pyridine. All three compounds at 3 mM gave positive morphological antisickling effects on homozygous SS cells under reduced O2 tension. Studies on two of these compounds, 2- and 3-(L- phenylalanylamino )pyridine, showed that these agents increase the deoxy-HbS solubility ratio, Cs/ Cs0 , by 14% at 20 mM. Observed changes in the mean corpuscular hemoglobin concentration (MCHC) values of treated cells ranged from 4% at 1.3 mM to 15% at 5.6 mM in compound concentration. Very minor lytic activity was found for treated cells, indicating water uptake is responsible for changes in the MCHC. Further, exposure of sickle cells to a 3 mM concentration of these agents also increased by 6- to 7-fold cellular deformability of a treated erythrocyte population as compared to an untreated one at the same total O2 saturation of 47%. These agents demonstrate the potential of bicyclic compounds composed of a common constituent, L-Phe, in the development toward a viable therapeutic agent.

  DOI：

  10.1021/jm00371a007

文献信息

• Molecularly-imprinted material made by template-directed synthesis
  申请人：——

  公开号：US20030139483A1

  公开（公告）日：2003-07-24

  A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase. When reactive monomers are allowed to polymerize in the water phase to form particles, the surface of the particles have cavities that are the mirror image of the imprint group.

  一种制造分子印迹多孔结构的方法利用了印迹分子的表面活性剂类似物，该类似物具有作为表面活性剂头基的印迹分子部分。允许表面活性剂类似物在混合物中自组装，以创建至少一个具有暴露的印迹基团的超分子结构。通过向混合物中添加反应性单体并允许单体聚合来形成印迹多孔结构，超分子结构作为模板。所得到的固体结构形状与超分子结构互补，并具有镜像印迹基囊的空腔。同样，可以通过使用表面活性剂创建水-油微乳液来制造分子印迹颗粒，其中印迹基团暴露在水相中。当允许反应性单体在水相中聚合形成颗粒时，颗粒的表面具有镜像印迹基囊的空腔。
• MOLECULARLY-IMPRINTED MATERIAL MADE BY TEMPLATE-DIRECTED SYNTHESIS
  申请人：——

  公开号：US20030191205A1

  公开（公告）日：2003-10-09

  A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase. When reactive monomers are allowed to polymerize in the water phase to form particles, the surface of the particles have cavities that are the mirror image of the imprint group.

  一种制备分子印迹多孔结构的方法利用了印迹分子的表面活性剂类似物，其中印迹分子部分充当表面活性剂头基。允许表面活性剂类似物在混合物中自组装，以创建至少一个具有暴露的印迹基团的超分子结构。通过向混合物中添加反应性单体并允许单体聚合，以超分子结构作为模板形成印迹多孔结构。所得到的固体结构的形状与超分子结构的形状互补，并且具有镜像印迹基囊的空腔。类似地，可以通过使用表面活性剂创建水-油微乳液来制备分子印迹颗粒，其中印迹基团暴露在水相中。当允许反应性单体在水相中聚合形成颗粒时，颗粒表面具有镜像印迹基囊的空腔。
• Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
  作者：Lei Zhang、Xiaojie Chen、Jun Liu、Qingzhang Zhu、Ying Leng、Xiaomin Luo、Hualiang Jiang、Hong Liu

  DOI：10.1016/j.ejmech.2012.06.020

  日期：2012.12

  Dual-target-directed agents simultaneously inhibiting glycogen phosphorylase (GP) and activating glucokinase (GK) could decelerate the inflow of glucose from glycogenolysis and accelerate the outflow of glucose in the liver, therefore allow for a better control over hyperglycaemia in a synergetic manner. A series of hybrid compounds were designed by structure-assisted and ligand-based strategies. In vitro bioassays found two novel compounds (1j, 6g) worthy of further optimization on balance of dual action to GP and GK. In addition, for single-target activity, two compounds exhibited more potent GP inhibitory activity and four compounds showed better GK activation than their corresponding references. (C) 2012 Elsevier Masson SAS. All rights reserved.
• US6310110B1
  申请人：——

  公开号：US6310110B1

  公开（公告）日：2001-10-30
• US6583191B2
  申请人：——

  公开号：US6583191B2

  公开（公告）日：2003-06-24