2-(3-甲氧基苯氧基)-N-甲基乙胺 | 120998-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-(3-甲氧基苯氧基)-N-甲基乙胺
• 英文名称: [2-(3-methoxy-phenoxy)-ethyl]-methyl-amine
• 英文别名: O-Methyl-O'-(2-methylamino-aethyl)-resorcin；2-Methylamino-1-(3-methoxy-phenoxy)-aethan；3-Methoxy-1-(2-methylamino-aethoxy)-benzol；[2-(3-Methoxy-phenoxy)-aethyl]-methyl-amin；2-(3-Methoxyphenoxy)-N-methylethanamine
• CAS: 120998-52-9
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: LEEHBTUHIYEAQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922299090
• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  1-(2-溴乙氧基)-3-甲氧基苯 、 甲胺 在 乙醇 作用下， 生成 2-(3-甲氧基苯氧基)-N-甲基乙胺
  参考文献：
  名称：

  Kuroda; Koyama, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1943, vol. 63, p. 387,389

  摘要：

  DOI：

文献信息

• Benzofuran derivatives, their preparation and use
  申请人：H. Lundbeck A/S

  公开号：US20020032205A1

  公开（公告）日：2002-03-14

  The present invention relates to benzofuran derivatives having general Formula (I) 1 wherein A is selected from (1), (2), (3), (4) 2 wherein Z is O or S; s is 0 or 1; q is 0 or 1; R 4 is hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, C 2 6 -alkynyl, C 1-6 -alkyl-aryl, or C 1-6 -alkyl-O-aryl; D is a spacer group selected from branched or straight chain C 1-6 -alkylene, C 2-6 -alkenylene and C 2-6 -alkynylene; its enantiomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT 1A receptor.

  本发明涉及具有一般式(I)的苯并呋喃衍生物，其中A从(1)，(2)，(3)，(4)中选择，其中Z为O或S；s为0或1；q为0或1；R4为氢，C1-6-烷基，C2-6烯基，C2-6炔基，C1-6烷基-芳基或C1-6烷基-O-芳基；D是从支链或直链C1-6-烷基，C2-6-烯基和C2-6-炔基中选择的间隔基；其对映体和药学上可接受的酸加成盐。这些化合物具有与5-HT1A受体的强结合能力。
• BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE
  申请人：H. Lundbeck A/S

  公开号：EP1137644A1

  公开（公告）日：2001-10-04
• US6492374B2
  申请人：——

  公开号：US6492374B2

  公开（公告）日：2002-12-10
• [EN] BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE<br/>[FR] DERIVES DE BENZOFURANE, LEUR PREPARATION ET LEUR APPLICATION
  申请人：LUNDBECK & CO AS H

  公开号：WO2000034263A1

  公开（公告）日：2000-06-15

  The present invention relates to benzofuran derivatives having general Formula (I). A is selected from (1), (2), (3), (4) wherein: Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C¿1-6?-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyl-Aryl, or C1-6-alkyl-O-Aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene; its enantiomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT1A receptor.
• [EN] ISOINDOLIN-1-ONES AS MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) INHIBITORS<br/>[FR] ISOINDOLIN-1-ONES UTILISÉES EN TANT QU'INHIBITEURS DU FACTEUR INHIBITEUR DE LA MIGRATION DES MACROPHAGES (MIF)
  申请人：CONTROLLED CHEMICALS INC

  公开号：WO2015095052A1

  公开（公告）日：2015-06-25

  Compounds having an isoindolin-1-one backbone of Formula (I) are disclosed which have utility in treating and/or preventing microbial infections, tumor growth, metastasis and other macrophage migration inhibitory factor (MIF)-modulated pathological conditions. Pharmaceutical compositions and methods and use of compounds of Formula (I) are also disclosed.