2E,8Z-Undecadienoic acid | 74267-92-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2E,8Z-Undecadienoic acid
• 英文别名: 2,4-trans,trans-Undecadiensaeure；2E,4E-undecadienoic acid；(2E,4E)-undeca-2,4-dienoic acid
• CAS: 74267-92-8
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: WXUGSDBMQDMRMU-XBLVEGMJSA-N

物化性质

• 沸点：
  309.2±11.0 °C(Predicted)
• 密度：
  0.949±0.06 g/cm3(Predicted)
• LogP：
  4.000 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2E,8Z-Undecadienoic acid 、 氯化亚砜 生成 (2E,4E)-Undeca-2,4-dienoyl chloride
  参考文献：
  名称：

  VIG B.; KANWAR R.; DAHIYA S. S., J. INDIAN CHEM. SOC., 1979, 56, NO 9, 935-937

  摘要：

  DOI：
• 作为产物：
  描述：

  庚醛 在 sodium hydroxide 作用下， 生成 2E,8Z-Undecadienoic acid
  参考文献：
  名称：

  Vig,B. et al., Journal of the Indian Chemical Society, 1979, vol. 56, p. 935 - 937

  摘要：

  DOI：

文献信息

• METAL ORGANIC LIQUID CRYSTAL DYES
  申请人：GAUZY LTD.

  公开号：US20170355908A1

  公开（公告）日：2017-12-14

  A dye composition dissolvable within a liquid crystal host device (including: polymer dispersed liquid crystal, polymer network liquid crystal, polymer stabilized liquid crystal, liquid crystal displays and similar devices), comprising eutectic mixtures of dichroic metallomesogen molecules. The aforesaid metallomesogen molecules comprise chromophore groups synthesized by physical and chemical mixing methods.

  一种可在液晶主机装置内溶解的染料组合物（包括：聚合物分散液晶、聚合物网络液晶、聚合物稳定液晶、液晶显示器和类似装置），包括二色性金属介晶分子的共晶混合物。上述金属介晶分子包括通过物理和化学混合方法合成的色团基团。
• E2,E4,Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same
  申请人：Dewis L. Mark

  公开号：US20050197387A1

  公开（公告）日：2005-09-08

  Described is a genus of undecatrienoic acid derivatives useful in imparting, augmenting and/or enhancing flavors, aromas and somatosensory effects in or to consumable materials such as foods, beverages, skin care products, oral care products, medicinal products and the like. Also described is a synthesis process for producing such derivatives.

  本文描述了一种十一烯三酸衍生物的属，可用于赋予、增强和/或提高可食用材料（如食品、饮料、皮肤护理产品、口腔护理产品、药品等）的味道、香气和体感效果。同时还描述了一种用于生产这种衍生物的合成过程。
• Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0595635A1

  公开（公告）日：1994-05-04

  α-Phosphonosulfonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These comounds have the formula wherein R² is OR⁵ or R5a; R³ and R⁵ are independently H, alkyl, arylalkyl, aryl or cycloalkyl; R5a is H, alkyl, arylalkyl or aryl; R4 is H, alkyl, aryl, arylalkyl, or cycloalkyl;, Z is H, halogen, lower alkyl or lower alkenyl; and R¹ is a lipophilic group which contains at least 7 carbons and is alkyl, alkenyl, alkynyl, mixed alkenyl-alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl; as further defined above; including pharmaceutically acceptable salts and or prodrug esters of the phosphonic (phosphinic) and/or sulfonic acids.

  提供了α-磷酸磺酸酯化合物，可抑制齿烷合酶酶并从而抑制胆固醇生物合成。这些化合物的化学式为：其中R²是OR⁵或R5a; R³和R⁵独立地为H，烷基，芳基烷基，芳基或环烷基; R5a为H，烷基，芳基烷基或芳基; R4为H，烷基，芳基，芳基烷基或环烷基; Z为H，卤素，低烷基或低烯基; R¹为至少含有7个碳的疏水基团，为烷基，烯基，炔基，混合烯基-炔基，芳基，芳基烷基，环烷基，环烷基烷基，杂环芳基，杂环芳基烷基，环杂芳基烷基，环杂芳基烷基烷基; 包括磷酸（磷酸酯）和/或磺酸的药物可接受盐和/或前药酯。
• Use of (<i>E</i>,<i>E</i>)-Dienoic Acids as Switchable (<i>E</i>,<i>E</i>)- and (<i>Z</i>,<i>E</i>)-Dienyl Anion Surrogates via Ligand-Controlled Palladium Catalysis
  作者：Shun-Zhong Tan、Peng Chen、Lei Zhu、Meng-Qi Gan、Qin Ouyang、Wei Du、Ying-Chun Chen

  DOI：10.1021/jacs.2c10004

  日期：2022.12.14

  intrinsic acidic group. Here, we demonstrate that free (E,E)-2,4-dienoic acids form electron-neutral and highest occupied molecular orbital-raised η2-complexes with Pd(0) and undergo Friedel–Crafts-type additions to imines with exclusive α-regioselectivity, giving formal dienylated products after decarboxylation. Unusual and switchable (E,E)- and (Z,E)-selectivity, along with excellent enantioselectivity

  由于其固有的酸性基团，羧酸不易用作碳基亲核试剂。在这里，我们证明游离 ( E , E )-2,4-二烯酸与 Pd(0) 形成电子中性和最高占据分子轨道升高的 η 2 -配合物，并通过 Friedel-Crafts 型加成亚胺α-区域选择性，脱羧后得到正式的二烯化产物。不寻常且可切换的 ( E , E )- 和 ( Z , E)-选择性以及出色的对映选择性分别通过配体控制的外球或内球反应模式实现，这得到了综合密度泛函理论计算研究的充分支持。( E , E )-二烯酸和亚胺之间前所未有的正式还原曼尼希反应也被开发出来以提供富含对映体的 β-氨基酸衍生物。
• Alpha-phosphorus substituted sulfinate derivatives as squalene synthetase inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0698609A1

  公开（公告）日：1996-02-28

  α-Phosphonosulfinate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula wherein R² is OR⁵ or R5a; R³ and R⁵ are independently H, alkyl, arylalkyl, aryl or cycloalkyl; R5a is alkyl, arylalkyl or aryl; R⁴ is H or pharmaceutically acceptable cation;, Z is H, halogen, lower alkyl or lower alkenyl; and R¹ is a lipophilic group which contains at least 7 carbons and is alkyl, alkenyl, alkynyl, mixed alkenyl-alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl; including pharmaceutically acceptable salts.

  α-膦酰亚磺酸盐化合物可抑制角鲨烯合成酶，从而抑制胆固醇的生物合成。这些化合物的化学式为 其中 R² 是 OR⁵ 或 R5a ；R³ 和 R⁵ 独立地是 H、烷基、芳烷基、芳基或环烷基；R5a 是烷基、芳烷基或芳基；R⁴ 是 H 或药学上可接受的阳离子；Z 是 H、卤素、低级烷基或低级烯基；和 R¹ 是亲脂基团，至少含有 7 个碳，并且是烷基、烯基、炔基、混合烯基-炔基、芳基、芳烷基、环烷基、环烷基烷基、杂芳基、杂芳基烷基、环杂烷基、环杂烷基烷基； 包括药学上可接受的盐类。