Boc-Ser(OPPh2)-OMe | 400644-14-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Ser(OPPh2)-OMe
• 英文别名: methyl (2S)-3-diphenylphosphanyloxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 400644-14-6
• 化学式: C₂₁H₂₆NO₅P
• 分子量: 403.415
• InChiKey: YMRAKIRYHBCUDB-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  二(氰基苯)二氯化钯 、 Boc-Ser(OPPh2)-OMe 以 二氯甲烷 为溶剂， 生成 [Boc-Ser(OPPh2)-OMe]2PdCl2
  参考文献：
  名称：

  Synthesis and study of amino acid based phosphinite ligands

  摘要：

  The preparation of the five new amino acid derived phosphinites Boc-Ser(OPPh2)-OMe (5), Boc-Thr(OPPh2)-OMe (6), Boc-Tyr(OPPh2)-OMe (7), Z-Ser(OPPh2)-OMe (8), and Z-beta-Ala-Tyr(OPPh2)-OMe (9) is reported together with their full spectroscopic characterization. These ligands readily complex to Pd(II) and Pt(II) giving the corresponding complexes [Boc-Ser(OPPh2)OMe](2)PtCl2 (10), [Boc-Tyr(OPPh2)-OMe](2)PtCl2 (11), [Boc-Thr(OPPh2)-OMe](2)PtCl2 (12), [Z-P-Ala-Tyr(OPPh2)-OMe](2)PtCl2 (13), [Boc-Ser(OPPh2)-OMe](2)PdCl2 (14), [Boc-Tyr(OPPh2)-OMe](2)PdCl2 (15), [Boc-Thr(OPPh2)-OMe](2)PdCl2 (16), [Z-beta-Ala-Tyr(OPPh2)OMe](2)-PdCl2-(17). The X-ray structure of 10 was determined and shows the ligands being cis coordinated around the Pt(II) center with Pt-P distances of 2.2278(13) Angstrom for Pt-P(1) and 2.2235(12) Angstrom for Pt-P(2). (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(03)00181-5
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Boc-Ser(OPPh2)-OMe
  参考文献：
  名称：

  Synthesis and study of amino acid based phosphinite ligands

  摘要：

  The preparation of the five new amino acid derived phosphinites Boc-Ser(OPPh2)-OMe (5), Boc-Thr(OPPh2)-OMe (6), Boc-Tyr(OPPh2)-OMe (7), Z-Ser(OPPh2)-OMe (8), and Z-beta-Ala-Tyr(OPPh2)-OMe (9) is reported together with their full spectroscopic characterization. These ligands readily complex to Pd(II) and Pt(II) giving the corresponding complexes [Boc-Ser(OPPh2)OMe](2)PtCl2 (10), [Boc-Tyr(OPPh2)-OMe](2)PtCl2 (11), [Boc-Thr(OPPh2)-OMe](2)PtCl2 (12), [Z-P-Ala-Tyr(OPPh2)-OMe](2)PtCl2 (13), [Boc-Ser(OPPh2)-OMe](2)PdCl2 (14), [Boc-Tyr(OPPh2)-OMe](2)PdCl2 (15), [Boc-Thr(OPPh2)-OMe](2)PdCl2 (16), [Z-beta-Ala-Tyr(OPPh2)OMe](2)-PdCl2-(17). The X-ray structure of 10 was determined and shows the ligands being cis coordinated around the Pt(II) center with Pt-P distances of 2.2278(13) Angstrom for Pt-P(1) and 2.2235(12) Angstrom for Pt-P(2). (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(03)00181-5

文献信息

• Synthesis and study of amino acid based phosphinite ligands
  作者：Patrycja W. Galka、Heinz-Bernhard Kraatz

  DOI：10.1016/s0022-328x(03)00181-5

  日期：2003.5

  The preparation of the five new amino acid derived phosphinites Boc-Ser(OPPh2)-OMe (5), Boc-Thr(OPPh2)-OMe (6), Boc-Tyr(OPPh2)-OMe (7), Z-Ser(OPPh2)-OMe (8), and Z-beta-Ala-Tyr(OPPh2)-OMe (9) is reported together with their full spectroscopic characterization. These ligands readily complex to Pd(II) and Pt(II) giving the corresponding complexes [Boc-Ser(OPPh2)OMe](2)PtCl2 (10), [Boc-Tyr(OPPh2)-OMe](2)PtCl2 (11), [Boc-Thr(OPPh2)-OMe](2)PtCl2 (12), [Z-P-Ala-Tyr(OPPh2)-OMe](2)PtCl2 (13), [Boc-Ser(OPPh2)-OMe](2)PdCl2 (14), [Boc-Tyr(OPPh2)-OMe](2)PdCl2 (15), [Boc-Thr(OPPh2)-OMe](2)PdCl2 (16), [Z-beta-Ala-Tyr(OPPh2)OMe](2)-PdCl2-(17). The X-ray structure of 10 was determined and shows the ligands being cis coordinated around the Pt(II) center with Pt-P distances of 2.2278(13) Angstrom for Pt-P(1) and 2.2235(12) Angstrom for Pt-P(2). (C) 2003 Elsevier Science B.V. All rights reserved.