5-(1H-benzo[d]imidazol-2-yl)thiazole | 90765-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-(1H-benzo[d]imidazol-2-yl)thiazole
• 英文别名: thiabendazole；2-thiazol-5-yl-1H-benzoimidazole；2--benzimidazol；2-<5>Thiazolyl-benzimidazole；2-(5-Thiazolyl)benzimidazol；Thiabendazol；5-(1H-benzimidazol-2-yl)-1,3-thiazole
• CAS: 90765-94-9
• 化学式: C₁₀H₇N₃S
• mdl: MFCD01574790
• 分子量: 201.252
• InChiKey: GVLDOZDIEFWUJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-溴甲基-7,8-二氟-2(1H)-喹啉酮 、 5-(1H-benzo[d]imidazol-2-yl)thiazole 生成 7,8-difluoro-4-((2-(thiazol-5-yl)-1H-benzo[d]imidazol-1-yl)-methyl)quinolin-2(1H)-one
  参考文献：
  名称：

  QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS

  摘要：

  本发明涉及式I的新型喹诺酮，其抑制可诱导型一氧化氮合酶，以及合成和使用该化合物的方法，包括通过给予该化合物治疗疾病的方法，用于抑制或调节一氧化氮合成和/或降低患者体内一氧化氮水平。

  公开号：

  US20080139558A1
• 作为产物：
  描述：

  5-噻唑甲醛 、 邻苯二胺 在 sodium disulfite 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 5-(1H-benzo[d]imidazol-2-yl)thiazole
  参考文献：
  名称：

  Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

  摘要：

  Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes indicate that the only route to guanine nucleotides is via inosine 5 '-monophosphate dehydrogenase (IMPDH). Thus the inhibition of the parasite IMPDH presents a potential strategy for treating Cryptosporidium infections. A selective benzimidazole-based inhibitor of C. parvum IMPDH (CpIMPDH) was previously identified in a high throughput screen. Here we report a structure-activity relationship study of benzimidazole-based compounds that resulted in potent and selective inhibitors of CpIMPDH. Several compounds display potent antiparasitic activity in vitro. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.029

文献信息

• Selective C–H trifluoromethylation of benzimidazoles through photoredox catalysis
  作者：Guo-Lin Gao、Chao Yang、Wujiong Xia

  DOI：10.1039/c6cc08975e

  日期：——

  This protocol presented a new strategy for visible-light induced C-H trifluoromethyltion at C4 of benzimidazoles using Togini's reagent in the presense of fac-Ir(ppy)3. It's Highlighted by its operational simplicity, mild...

  该协议提出了一种新的策略，以fac-Ir（ppy）3为代表，使用Togini试剂在苯并咪唑的C4处引起CH三氟甲基CH的三氟甲基化反应。它以其操作简单，温和而着称。
• A Poly(carbazole-alt-triazole) with Thiabendazole Side Groups as an “On-Off-On” Fluorescent Probe for Detection of Cu(II) Ion and Cysteine
  作者：Liting Gao、Jinyao Xu、Haoyue Luo、Hong Lei、Xinai Chen、Jiayi Wan、Juhua Feng、Kuan Liu

  DOI：10.1007/s10895-023-03164-9

  日期：——

  A novel conjugated polymer PCZBTA-TBZ containing thiabendazole as recognition unit was synthesized via Suzuki coupling reaction, and its structural characterization, spectroscopic analysis and photophysical properties were investigated. In the metal ion response study, the addition of Cu2+ led to the occurrence of the photoinduced electron transfer (PET) mechanism, which significantly quenched the

  通过Suzuki偶联反应合成了一种以噻菌灵为识别单元的新型共轭聚合物PCZBTA-TBZ，并对其结构表征、光谱分析和光物理性质进行了研究。在金属离子响应研究中，Cu 2+的添加导致光致电子转移（PET）机制的发生，显着猝灭了聚合物PCZBTA-TBZ的荧光，猝灭效果高达98%。此外，I -可以显着猝灭聚合物的荧光，但其他阴离子则没有这种作用。根据密度泛函理论计算，与其他聚咔唑或其他含咔唑的替代共聚物相比，咔唑和三唑的交替增强了聚合物的电子迁移率并降低了聚合物的能带隙。由于Cu 2+与Cys之间较强的配位能力，添加的Cys与[PCZBTA-TBZ-Cu 2+ ]配合物中的Cu 2+竞争，阻断了PET的发生，PCZBTA-TBZ的荧光强度得到恢复。添加其他氨基酸几乎没有引起任何变化。该聚合物有望用于特定金属离子和Cys的双荧光检测。
• Plant growth regulators
  申请人：COALITE GROUP PLC

  公开号：EP0087269A1

  公开（公告）日：1983-08-31

  .The plant growth regulators proposed by the invention comprise an inert carrier or diluent and, as the active substance, at least one substituted maphthalene, preferably in combination with another growth regulator, not being a substituted napthalene.

  .本发明提出的植物生长调节剂包括惰性载体或稀释剂，以及作为活性物质的至少一种取代的间苯二酚，最好与另一种生长调节剂（不是取代的萘类）混合使用。
• Tetraarylboron-ammonium complexes and their uses
  申请人：HOKKO CHEMICAL INDUSTRY CO., LTD

  公开号：EP0153885A1

  公开（公告）日：1985-09-04

  New tetraarylboron-ammonium complexes having the ganeral formula: wherain R1 represents a hydrogen or a halogen atom or a lower alkyl group; R2 represents a halogen atom or a lower alkyl or a lower alkenyl group; and R3 represents a heterocyclic amine are provided as active ingredient of anti- fouling paint and also of antiseptic, antifungal agent. These compounds exhibit remarkably long-lasting anti-fouling activities against substantially all kinds of aquatic organisms Including slimes with acceptably low toxicity against human beings and also exhibit high antimicrobial activites against various fungi, bacteria and yeasts.

  新的四芳基硼铵盐络合物具有以下分子式：R1 代表氢原子、卤素原子或低级烷基；R2 代表卤素原子、低级烷基或低级烯基；R3 代表杂环胺，可作为防污涂料和防腐剂、防霉剂的活性成分。 这些化合物对包括淤泥在内的各种水生生物都具有显著的长效防污活性，对人体的毒性很低，对各种真菌、细菌和酵母菌也具有很高的抗菌活性。
• Fungicide and its use
  申请人：TOKUYAMA CORPORATION

  公开号：EP0588601A1

  公开（公告）日：1994-03-23

  A fungicide containing, as an active ingredient, a metal complex of the formula (I), [MW-Si(OA¹)kA2  3-k}g]Zf   (I)    wherein M is a silver, copper or zinc ion, W is an optionally substituted aminoalkyl group as defined in claim 1, Z is an anion, A¹ and A² each independently represent an alkyl group, k is an integer of 1 to 3, g is an integer of 1 to 6 and f is 1 or 2, can be used as a fungicide in a variety of applications.

  一种杀真菌剂，含有式(I)的金属络合物作为活性成分，[MW-Si(OA¹)kA2 3-k}g]Zf (I) 其中 M 是银、铜或锌离子，W 是权利要求 1 中定义的任选取代的氨基烷基，Z 是阴离子，A¹ 和 A² 各自独立地代表一个烷基，k 是 1 至 3 的整数，g 是 1 至 6 的整数，f 是 1 或 2。