ethyl 2-(N-benzoyl-S-phenylsulfonimidoyl)-2-phenylacetate | 850694-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-(N-benzoyl-S-phenylsulfonimidoyl)-2-phenylacetate
• CAS: 850694-51-8
• 化学式: C₂₃H₂₁NO₄S
• 分子量: 407.49
• InChiKey: NNNBSVVSPHJHKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  81.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-(N-benzoyl-S-phenylsulfonimidoyl)-2-phenylacetate 在 sodium hydroxide 、 硼烷 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 5.0h， 生成 (benzyl)(imino)(phenyl)-λ⁶-sulfanone
  参考文献：
  名称：

  Palladium-Catalyzed α-Arylation of Sulfoximines

  摘要：

  Palladium-catalyzed alpha-arylation of N-benzoyl sulfoximine ethyl ester with various aryl bromides leads to alpha-arylated products that can easily be hydrolyzed, giving the corresponding N-protected benzyl phenyl sulfoximines. In this manner, new sulfoximine derivatives are accessible that have so far been difficult to prepare in enantiopure form.

  DOI：

  10.1021/ol050176b
• 作为产物：
  描述：

  N-benzoyl-S-methyl-S-phenylsulfoximine 在 palladium diacetate 正丁基锂 、 tetramethylpiperidine 、 sodium t-butanolate 、 三环己基膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 正己烷 为溶剂， 反应 2.0h， 生成 ethyl 2-(N-benzoyl-S-phenylsulfonimidoyl)-2-phenylacetate
  参考文献：
  名称：

  Palladium-Catalyzed α-Arylation of Sulfoximines

  摘要：

  Palladium-catalyzed alpha-arylation of N-benzoyl sulfoximine ethyl ester with various aryl bromides leads to alpha-arylated products that can easily be hydrolyzed, giving the corresponding N-protected benzyl phenyl sulfoximines. In this manner, new sulfoximine derivatives are accessible that have so far been difficult to prepare in enantiopure form.

  DOI：

  10.1021/ol050176b

文献信息

• Palladium-Catalyzed α-Arylation of Sulfoximines
  作者：Gae Young Cho、Carsten Bolm

  DOI：10.1021/ol050176b

  日期：2005.3.1

  Palladium-catalyzed alpha-arylation of N-benzoyl sulfoximine ethyl ester with various aryl bromides leads to alpha-arylated products that can easily be hydrolyzed, giving the corresponding N-protected benzyl phenyl sulfoximines. In this manner, new sulfoximine derivatives are accessible that have so far been difficult to prepare in enantiopure form.