(E)-5-(2-methoxystyryl)oxazole | 1276118-92-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-5-(2-methoxystyryl)oxazole
• 英文别名: 5-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-oxazole
• CAS: 1276118-92-3
• 化学式: C₁₂H₁₁NO₂
• 分子量: 201.225
• InChiKey: ZHWMIVFBDFNJIF-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-5-(2-methoxystyryl)oxazole 在 碘 作用下， 以 苯 为溶剂， 反应 20.0h， 以70%的产率得到6-methoxynaphtho[1,2-d]oxazole
  参考文献：
  名称：

  Photochemical Approach to Naphthoxazoles and Fused Heterobenzoxazoles from 5-(Phenyl/heteroarylethenyl)oxazoles

  摘要：

  A new synthetic approach is presented for the synthesis of naphthoxazoles and fused heterobenzoxazoles. The starting 5-(aryl/furyl/thienyl/pyridyl ethenyl)oxazoles are prepared from the corresponding alpha,beta-unsaturated aldehydes using Van Leusen reagent in very good yields and are transformed into naphthoxazoles and fused heterobenzoxazoles on irradiation under aerobic conditions and in the presence of iodine.

  DOI：

  10.1021/jo1025942
• 作为产物：
  描述：

  2-甲氧基肉桂醛 、 对甲基苯磺酰甲基异腈 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 以65%的产率得到(E)-5-(2-methoxystyryl)oxazole
  参考文献：
  名称：

  Photochemical Approach to Naphthoxazoles and Fused Heterobenzoxazoles from 5-(Phenyl/heteroarylethenyl)oxazoles

  摘要：

  A new synthetic approach is presented for the synthesis of naphthoxazoles and fused heterobenzoxazoles. The starting 5-(aryl/furyl/thienyl/pyridyl ethenyl)oxazoles are prepared from the corresponding alpha,beta-unsaturated aldehydes using Van Leusen reagent in very good yields and are transformed into naphthoxazoles and fused heterobenzoxazoles on irradiation under aerobic conditions and in the presence of iodine.

  DOI：

  10.1021/jo1025942

文献信息

• Photochemical Approach to Naphthoxazoles and Fused Heterobenzoxazoles from 5-(Phenyl/heteroarylethenyl)oxazoles
  作者：Ivana Šagud、Fabio Faraguna、Željko Marinić、Marija Šindler-Kulyk

  DOI：10.1021/jo1025942

  日期：2011.4.15

  A new synthetic approach is presented for the synthesis of naphthoxazoles and fused heterobenzoxazoles. The starting 5-(aryl/furyl/thienyl/pyridyl ethenyl)oxazoles are prepared from the corresponding alpha,beta-unsaturated aldehydes using Van Leusen reagent in very good yields and are transformed into naphthoxazoles and fused heterobenzoxazoles on irradiation under aerobic conditions and in the presence of iodine.