4'-nonylbiphenyl-4-carboxylic acid ester | 118826-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-nonylbiphenyl-4-carboxylic acid ester
• 英文别名: 4'-Nonylbiphenyl-4-carboxylic acid；4'-nonyl-4-biphenylcarboxylic acid；4'-nonyl-biphenyl-4-carboxylic acid；4-(4-nonylphenyl)benzoic acid
• CAS: 118826-99-6
• 化学式: C₂₂H₂₈O₂
• 分子量: 324.463
• InChiKey: JEDSQOLKNJLVRX-UHFFFAOYSA-N

物化性质

• 沸点：
  474.0±34.0 °C(Predicted)
• 密度：
  1.028±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-nonylbiphenyl-4-carboxylic acid ester 在 sodium hydroxide 、 硼烷四氢呋喃络合物 、 sodium ethanolate 、 三溴化磷 作用下， 以 乙醇 、 苯 为溶剂， 生成 2-(4'-Nonyl-biphenyl-4-ylmethyl)-malonic acid
  参考文献：
  名称：

  Hall, A. W.; Lacey, D.; Holmes, D., Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 250, p. 333 - 346

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(4-壬基苯基)苯甲酸乙酯 在 lithium hydroxide 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以68%的产率得到4'-nonylbiphenyl-4-carboxylic acid ester
  参考文献：
  名称：

  WO2007/9083

  摘要：

  公开号：

文献信息

• A synthetic strategy toward branched oligomesogenic phosphonic acids: comparison of alternative pathways
  作者：Maksym F. Prodanov、Olga V. Vashchenko、Valerii V. Vashchenko

  DOI：10.1016/j.tetlet.2013.11.022

  日期：2014.1

  This work is devoted to the elaboration of a practical scheme for the synthesis of dendritic derivatives of gallic acid containing a carboxylate-ω-alkylphosphonic acid group and three terminal promesogenic substituents. Two synthetic strategies toward the target compounds were examined that differ in the sequence of the introduction of the promesogenic units and ω-alkylphosphonic group.

  这项工作致力于阐述一种实用的方案，用于合成含有羧酸盐-ω-烷基膦酸基团和三个末端产前取代基的没食子酸的树枝状衍生物。研究了针对目标化合物的两种合成策略，它们在促生型单元和ω-烷基膦酸基团的引入顺序上有所不同。
• Direct transition from a nematic phase to a polar biaxial smectic A phase in a homologous series of unsymmetrically substituted bent-core compoundsElectronic supplementary information (ESI) available: physical and spectral data obtained for the compounds of series 1j, 1k and 1l. See http://www.rsc.org/suppdata/jm/b3/b309262c/
  作者：R. Amaranatha Reddy、B. K. Sadashiva

  DOI：10.1039/b309262c

  日期：——

  The synthesis and characterization of twenty seven new compounds belonging to three homologous series of compounds derived from 3-hydroxybenzoic acid are reported. One of the terminal positions of the constituent molecules of these compounds is substituted with a strongly polar cyano group while the other end contains an n-alkyl chain attached to a biphenyl moiety. Twenty two of these compounds show the polar partial bilayer biaxial smectic A phase which is antiferroelectric in nature. In addition, a direct transition from the nematic phase to the polar partial bilayer biaxial smectic A phase which has not been seen before is also reported. The mesophases have been characterized using polarized light optical microscopy, differential scanning calorimetry, X-ray diffraction studies and electro-optical experiments.

  报告中介绍了属于 3-hydroxybenzoic acid 衍生的三个同源化合物系列的 27 种新化合物的合成和特性。这些化合物组成分子的一个末端位置被一个强极性氰基取代，而另一端则含有一个连接到联苯分子上的正烷基链。这些化合物中有 22 种显示出极性部分双层双轴平滑 A 相，其性质为反铁电性。此外，还报道了从向列相直接过渡到极性部分双双轴 Smectic A 相的情况，这是以前从未见过的。利用偏振光光学显微镜、差示扫描量热法、X 射线衍射研究和电光实验对这些介相进行了表征。
• Liquid crystal compounds
  申请人：Showa Shell Sekiyu Kabushiki Kaisha

  公开号：US05184847A1

  公开（公告）日：1993-02-09

  Ferrelectric chiral smetic liquid crystal compound are provided which have the formula, for example ##STR1## wherein R is a C.sub.1-20 alkyl group.

  提供了具有以下公式的Ferrelectric手性液晶化合物，例如 ##STR1## 其中R是C.sub.1-20烷基。
• BRIDGED LIPOGLYCOPEPTIDES THAT POTENTIATE THE ACTIVITY OF BETA-LACTAM ANTIBACTERIALS
  申请人：Gallant Michel

  公开号：US20130244929A1

  公开（公告）日：2013-09-19

  The present invention provides novel lipoglycopeptide compounds which are Type 1 signal peptidase inhibitors (SpsB). Compounds of the present invention are useful for the treatment of various bacterial related infectious diseases, particularly when used as a potentiator of a β-lactam antibiotic such as imipenem and ertapenem. Accordingly, the present invention provides a method for the treatment of bacterial related infections using the compounds described herein, either alone or in combination with a β-lactam antibiotic.

  本发明提供了一种新型的脂肽多糖肽类化合物，它们是一类信号肽酶抑制剂（SpsB）。本发明的化合物可用于治疗各种细菌相关感染疾病，特别是在与β-内酰胺类抗生素（如亚胺培南和依达拉奉）一起使用时作为增效剂。因此，本发明提供了一种使用本文所述化合物单独或与β-内酰胺类抗生素联合治疗细菌相关感染的方法。
• COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS
  申请人：Olsson Roger

  公开号：US20090176837A1

  公开（公告）日：2009-07-09

  Disclosed herein are novel compounds with activity at RARβ 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders such as memory deficits and schizophrenia, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, inflammatory disorders such as psoriasis and rheumatoid arthritis, eye disorders and depression.

  本文揭示了具有对RARβ 2受体活性的新化合物。进一步揭示了这些化合物的用途，用于治疗或缓解癌症、神经系统疾病（如记忆障碍和精神分裂症）、神经退行性疾病（如帕金森病和阿尔茨海默病）、炎症性疾病（如银屑病和类风湿性关节炎）、眼部疾病和抑郁症状。