Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
申请人:Aventis Pharma Deutschland GmbH
公开号:US20030162967A1
公开(公告)日:2003-08-28
The present invention relates to compounds of the formula I,
1
in which A, L, Y, and k have the meanings indicated in the specification and claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa and/or factor VIIa and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of conditions in which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula 1, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
本发明涉及公式I的化合物,其中A、L、Y和k的含义如规范和权利要求所示。公式I的化合物是有价值的药理活性化合物。它们表现出强烈的抗血栓作用,适用于治疗和预防心血管疾病,如血栓栓塞性疾病或再狭窄。它们是血液凝固酶因子Xa和/或因子VIIa的可逆抑制剂,通常适用于存在不良因子Xa和/或因子VIIa活性的情况,或用于治疗或预防需要抑制因子Xa和/或因子VIIa的情况。本发明还涉及制备公式1的化合物的过程,它们的用途,特别是作为药物中的活性成分,以及包含它们的制药制剂。