[3-Acetyloxy-4,6-dimethyl-2-(quinolin-8-ylcarbamoyl)phenyl] acetate | 1200444-77-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-Acetyloxy-4,6-dimethyl-2-(quinolin-8-ylcarbamoyl)phenyl] acetate
• 英文别名: [3-acetyloxy-4,6-dimethyl-2-(quinolin-8-ylcarbamoyl)phenyl] acetate
• CAS: 1200444-77-4
• 化学式: C₂₂H₂₀N₂O₅
• 分子量: 392.411
• InChiKey: SAULKHUWYMZPTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  94.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  碘苯二乙酸 、 3,5-dimethyl-N-(quinolin-8-yl)benzamide 在 palladium diacetate 、 乙酸酐 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 18.0h， 以68%的产率得到[3-Acetyloxy-4,6-dimethyl-2-(quinolin-8-ylcarbamoyl)phenyl] acetate
  参考文献：
  名称：

  Palladium-Catalyzed Aryl C−H Bonds Activation/Acetoxylation Utilizing a Bidentate System

  摘要：

  A palladium-catalyzed aryl C-H bonds activation/acetoxylation reaction utilizing a bidentate system has been explored. This transformation has been applied to a wide array of pyridine and 8-aminoquinoline derivatives and it exhibits excellent functional group tolerance.

  DOI：

  10.1021/ol902497k

文献信息

• Palladium-Catalyzed Aryl C−H Bonds Activation/Acetoxylation Utilizing a Bidentate System
  作者：Fa-Rong Gou、Xiang-Chuan Wang、Peng-Fei Huo、Hai-Peng Bi、Zheng-Hui Guan、Yong-Min Liang

  DOI：10.1021/ol902497k

  日期：2009.12.17

  A palladium-catalyzed aryl C-H bonds activation/acetoxylation reaction utilizing a bidentate system has been explored. This transformation has been applied to a wide array of pyridine and 8-aminoquinoline derivatives and it exhibits excellent functional group tolerance.