(1-methoxyethyl)diphenylphosphine oxide | 64304-77-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-methoxyethyl)diphenylphosphine oxide
• 英文别名: 1-methoxyethyl(diphenyl)phosphine oxide；(methoxymethyl)diphenylphosphine oxide；(methoxyethyl)diphenylphosphine oxide；Methoxyethyl-diphenyl-phosphinoxid；Phosphine oxide, (1-methoxyethyl)diphenyl-；[1-methoxyethyl(phenyl)phosphoryl]benzene
• CAS: 64304-77-4
• 化学式: C₁₅H₁₇O₂P
• 分子量: 260.273
• InChiKey: DMQIMZHESVGADX-UHFFFAOYSA-N

物化性质

• 熔点：
  60-62 °C
• 沸点：
  344.5±25.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1-methoxyethyl)diphenylphosphine oxide 、 6-甲氧基-3,3-二甲基己-5-烯醛 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 1,7-dimethoxy-4,4-dimethyl-(E,Z)-1,6-octadiene
  参考文献：
  名称：

  Intramolecular Anodic Olefin Coupling Reactions: A New Approach to the Synthesis of Angularly Fused, Tricyclic Enones

  摘要：

  A number of intramolecular anodic olefin coupling reactions have been examined in order to determine the feasibility of using a sequential electrochemical oxidation-aldol condensation approach for constructing polycyclic enones. Initially, substrates comprised of an aldehyde enol ether tethered to a ketone enol ether were examined. In a model study, it was shown that such a substrate could lead to a successful electrochemical oxidation-aldol condensation sequence. However, the difficulties associated with both the synthesis and the poor stability of the ketone enol ethers greatly reduced the potential utility of this approach. This problem was circumvented by taking advantage of the compatibility of allylsilane groups with the electrolysis reaction. In these examples, ozonolysis of the electrochemical cyclization product afforded the 1,4-dicarbonyl substrate needed for the aldol condensation. The use of the less reactive allylsilane group in the electrochemical reaction still allowed for the construction of quaternary carbons. Finally a pair of angularly fused, tricyclic enones were synthesized. The regiochemistry of the enone in the product could be controlled by the proper choice of the substrate for the electrolysis and manipulation of the resulting cyclized product.

  DOI：

  10.1021/jo00088a019
• 作为产物：
  描述：

  (α-methoxyethyl)triphenylphosphonium chloride 在 sodium hydroxide 作用下， 生成 (1-methoxyethyl)diphenylphosphine oxide
  参考文献：
  名称：

  Earnshaw,C. et al., Journal of the Chemical Society. Perkin transactions I, 1979, p. 3099 - 3106

  摘要：

  DOI：
• 作为试剂：
  描述：

  6-methoxy-2',6'-bis(methoxymethoxy)biphenyl-2-carboxaldehyde 在 正丁基锂 、 (1-methoxyethyl)diphenylphosphine oxide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 19.92h， 生成
  参考文献：
  名称：

  通过中型内酯桥的Atrop-非对映选择性形成轴向手性联芳的新方法

  摘要：

  摘要 在C2'位置被含有立体异构中心的链烷酸侧链取代的联苯-2,6-二醇经历了高度对位立体选择性的九元内酯形成，并带有非对映异构的羟基基团。 在C2'位置被含有立体异构中心的链烷酸侧链取代的联苯-2,6-二醇经历了高度对位立体选择性的九元内酯形成，并带有非对映异构的羟基基团。

  DOI：

  10.1055/s-0035-1561477

文献信息

• First Total Synthesis of Dermocanarin 2
  作者：Keisuke Suzuki、Takashi Matsumoto、Satoru Yamaguchi、Nobuyuki Takahashi、Daisuke Yuyama、Kayo Sakamoto

  DOI：10.1055/s-0035-1561417

  日期：——

  The first total synthesis of dermocanarin 2 is described. The synthesis features the construction of the anthraquinone and naphthoquinone frameworks through annulation reactions onto an axially chiral biphenyl intermediate, obtained by an enzyme-catalyzed enantioselective desymmetrization of a σ-symmetric precursor, followed by a stereoselective aldol reaction to construct the stereogenic center in

  描述了 dermocarin 2 的第一次全合成。该合成的特点是通过对轴向手性联苯中间体的环化反应构建蒽醌和萘醌骨架，该中间体是通过酶催化对映选择性去对称化 σ 对称前体获得的，然后进行立体选择性羟醛反应以构建侧面的立体中心链。
• Preparation of α-oxygenated phosphine oxides from chlorodiphenylphosphine
  作者：Mehran Maleki、Allen Miller、O.William Lever

  DOI：10.1016/0040-4039(81)80100-1

  日期：1981.1

  A range of α-alkoxyphosphine oxides, including novel α-methoxyallyl oxides, are readily prepared from chlorodiphenylphosphine and acetals.

  各种α-烷氧基膦氧化物，包括新型的α-甲氧基烯丙基氧化物，很容易从氯二苯基膦和缩醛制备。
• Pd2+-promoted cyclization in tetracyclic diterpene synthesis highly diastereoselective formal total synthesis of (±)-stemodin
  作者：Masahiro Toyota、Takashi Seishi、Keiichiro Fukumoto

  DOI：10.1016/s0040-4039(00)73821-4

  日期：1993.9

  reaction of the triene 5 and Pd2+-promoted cyclization reaction of the olefinic silyl enol ether of 10 have been utilized as the key steps for a conceptually new, highly diastereocontrolled formal total synthesis of (±) stemodin (1).

  三烯5的分子内Diels-Alder反应和Pd 2+促进的10烯丙基甲硅烷基烯醇醚的环化反应已用作概念上新的，高度非对映控制的正式全合成（±）蛇毒蛋白的关键步骤（1） 。
• Synthesis of (+)-tricyclohexaprenol, a possible precursor of a family of tricyclic geoterpanes, and synthesis of an isomer
  作者：Denis Heissler、Claude Ladenburger

  DOI：10.1016/s0040-4020(01)81703-8

  日期：1988.1

  A synthesis of (+)-tricyclohexaprenol starting from isocopalenol and asynthesis of its isomer starting from -(14αH)-isocopalenol are described.

  描述了从异戊烯醇开始的（+）-三环己烯醇的合成和从-（14αH）-异铜烯醇开始的其异构体的合成。
• POLYMER ELECTROLYTE COMPOSITION AND POLYMER ELECTROLYTE MEMBRANE, MEMBRANE-ELECTROLYTE ASSEMBLY, AND SOLID POLYMER FUEL CELL USING SAME
  申请人：Toray Industries, Inc.

  公开号：EP3131145A1

  公开（公告）日：2017-02-15

  [Problem] To provide: a polymer electrolyte composition that has excellent chemical stability that makes it possible to withstand a strong oxidizing atmosphere during fuel cell operation, that makes it possible to achieve excellent protonic conductivity under low humidity conditions, excellent mechanical strength, and excellent physical durability, and that is highly practical; and a polymer electrolyte membrane, a membrane-electrode assembly, and a solid polymer fuel cell that use the polymer electrolyte composition. [Solution] A polymer electrolyte composition that comprises at least an ionic group-containing polymer (A), an organic phosphorus-based additive (C), and a nitrogen-containing heteroaromatic ring system additive (D) and that is characterized by the nitrogen-containing heteroaromatic ring system additive (D) comprising at least three nitrogen-containing heteroaromatic rings within a molecule thereof. In addition, the polymer electrolyte membrane, the catalyst layer-equipped electrolyte membrane, the membrane-electrode assembly, and the solid polymer fuel cell of the present invention are characterized by being configured using the polymer electrolyte composition.

  问题 提供一种聚合物电解质组合物，该组合物具有优异的化学稳定性，能够在燃料电池运行期间耐受强氧化性气氛，能够在低湿度条件下实现优异的质子电导率，具有优异的机械强度和优异的物理耐久性，并且具有很高的实用性；以及一种使用该聚合物电解质组合物的聚合物电解质膜、膜电极组件和固体聚合物燃料电池。[解决方案]一种聚合物电解质组合物，它至少包含一种含离子基团的聚合物（A）、一种有机磷基添加剂（C）和一种含氮杂芳香族环系添加剂（D），其特征在于含氮杂芳香族环系添加剂（D）在其分子内至少包含三个含氮杂芳香族环。此外，本发明的聚合物电解质膜、配备催化剂层的电解质膜、膜电极组件和固体聚合物燃料电池的特征在于使用聚合物电解质组合物进行配置。