2,2'-bis[2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy]biphenyl | 1312092-15-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-bis[2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy]biphenyl
• 英文别名: 2-[2-[2-[2-[2-[2-[2-[2-(4-Methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]phenyl]phenoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate；2-[2-[2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]phenyl]phenoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
• CAS: 1312092-15-1
• 化学式: C₃₈H₄₆O₁₂S₂
• 分子量: 758.908
• InChiKey: QVAZKZDLPXCOFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  52
• 可旋转键数：
  25
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  159
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (RS)-(6,6'-dihydroxybiphenyl-2,2'-diyl)bis(diphenylphosphine oxide) 、 2,2'-bis[2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy]biphenyl 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 以49%的产率得到
  参考文献：
  名称：

  Allosteric P═O-Based Receptors for Dicarboxylic Acids

  摘要：

  The synthesis of new P=O-disubstituted receptors with appended crown ethers and their properties as receptors for dicarboxylic acids have been studied. High affinities have been observed (oxalic and malonic acids with 4-, 5-, 6-, or 8-crown ethers). Binding of a cationic effector within the crown ether unit resulted in a positive "allostere" effect, which has been determined to be K-rol = 7 in the best case (binding of malonic acid with Li+ @ rao-3b).

  DOI：

  10.1021/ol201277d
• 作为产物：
  描述：

  2,2'-二羟基联苯 、 三乙二醇单对甲苯磺酸酯 在 caesium carbonate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 2,2'-bis[2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy]biphenyl
  参考文献：
  名称：

  Allosteric P═O-Based Receptors for Dicarboxylic Acids

  摘要：

  The synthesis of new P=O-disubstituted receptors with appended crown ethers and their properties as receptors for dicarboxylic acids have been studied. High affinities have been observed (oxalic and malonic acids with 4-, 5-, 6-, or 8-crown ethers). Binding of a cationic effector within the crown ether unit resulted in a positive "allostere" effect, which has been determined to be K-rol = 7 in the best case (binding of malonic acid with Li+ @ rao-3b).

  DOI：

  10.1021/ol201277d

文献信息

• Allosteric P═O-Based Receptors for Dicarboxylic Acids
  作者：D. Amilan Jose、Ignasi Mon、Héctor Fernández-Pérez、Eduardo C. Escudero-Adán、J. Benet-Buchholz、Anton Vidal-Ferran

  DOI：10.1021/ol201277d

  日期：2011.7.15

  The synthesis of new P=O-disubstituted receptors with appended crown ethers and their properties as receptors for dicarboxylic acids have been studied. High affinities have been observed (oxalic and malonic acids with 4-, 5-, 6-, or 8-crown ethers). Binding of a cationic effector within the crown ether unit resulted in a positive "allostere" effect, which has been determined to be K-rol = 7 in the best case (binding of malonic acid with Li+ @ rao-3b).