methyl (2S)-2-[[(2S,3S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[[(2S)-2-[[(2S)-1-[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidin-2-yl]methoxy]-3-phenylpropanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate | 112374-76-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-[[(2S,3S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[[(2S)-2-[[(2S)-1-[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidin-2-yl]methoxy]-3-phenylpropanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate
• CAS: 112374-76-2
• 化学式: C₆₉H₉₀N₁₀O₁₅S₂
• 分子量: 1363.66
• InChiKey: LLARSSQEOHPQQE-AMOFUWTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.67
• 重原子数：
  96.0
• 可旋转键数：
  32.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  334.72
• 氢给体数：
  6.0
• 氢受体数：
  19.0

反应信息

• 作为反应物：
  描述：

  methyl (2S)-2-[[(2S,3S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[[(2S)-2-[[(2S)-1-[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidin-2-yl]methoxy]-3-phenylpropanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate 在 1-羟基苯并三唑 作用下， 以 四氢呋喃 为溶剂， 反应 168.0h， 以77%的产率得到methyl (2S)-2-[[(2S,3S)-2-[[(3S,4S)-3-hydroxy-4-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidin-2-yl]methoxy]-3-phenylpropanoyl]amino]propanoyl]amino]-6-methylheptanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate
  参考文献：
  名称：

  Renin inhibitors containing .psi.[CH2O] pseudopeptide inserts

  摘要：

  Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu psi[CH2O]Val (3), and Leu psi[CH2O]Leu (4) at the P1-P1' site, were of a comparable potency to RIP. N-Terminal Boc-protected inhibitors containing Pro psi[CH2O]Phe in positions P4-P3 were potent inhibitors of renin, with Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl) pyridine (17) having an IC50 of 1.6 X 10(-9) M.

  DOI：

  10.1021/jm00398a029
• 作为产物：
  描述：

  tert-butyl (2S)-2-[[(2S)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-1-[[(2S,3S)-1-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-6-methyl-1-oxoheptan-4-yl]amino]-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]oxymethyl]pyrrolidine-1-carboxylate 、 N-叔丁氧羰基-N(咪唑)-(4-甲基苯磺酰基)-L-组氨酸 在 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 生成 methyl (2S)-2-[[(2S,3S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[[(2S)-2-[[(2S)-1-[(2S)-3-[1-(4-methylphenyl)sulfonylimidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidin-2-yl]methoxy]-3-phenylpropanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate
  参考文献：
  名称：

  Renin inhibitors containing .psi.[CH2O] pseudopeptide inserts

  摘要：

  Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu psi[CH2O]Val (3), and Leu psi[CH2O]Leu (4) at the P1-P1' site, were of a comparable potency to RIP. N-Terminal Boc-protected inhibitors containing Pro psi[CH2O]Phe in positions P4-P3 were potent inhibitors of renin, with Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl) pyridine (17) having an IC50 of 1.6 X 10(-9) M.

  DOI：

  10.1021/jm00398a029

文献信息

• TENBRINK, RUTH E.;PALS, DONALD T.;HARRIS, DOUGLAS W.;JOHNSON, GARLAND A., J. MED. CHEM., 31,(1988) N 3, 671-677
  作者：TENBRINK, RUTH E.、PALS, DONALD T.、HARRIS, DOUGLAS W.、JOHNSON, GARLAND A.

  DOI：——

  日期：——