(R)-trifluoromethylphenylacetic acid | 13491-17-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-trifluoromethylphenylacetic acid
• 英文别名: (R)-(-)-α-Trifluormethyl-phenylessigsaeure；(r)-alpha-Trifluoromethylphenylacetic acid；(2R)-3,3,3-trifluoro-2-phenylpropanoic acid
• CAS: 13491-17-3
• 化学式: C₉H₇F₃O₂
• 分子量: 204.149
• InChiKey: HQRSIMQXCAWAJB-SSDOTTSWSA-N

物化性质

• 沸点：
  239.1±40.0 °C(Predicted)
• 密度：
  1.356±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (R)-trifluoromethylphenylacetic acid 在 氯化亚砜 作用下， 生成 (+)-α-Trifluoromethylphenylacetylchlorid
  参考文献：
  名称：

  Mechanism of decarbonylation of acid chlorides by chlorotris(triphenylphosphine)rhodium(I). Stereochemistry

  摘要：

  DOI：

  10.1021/ja00812a039
• 作为产物：
  描述：

  3,3,3-三氟-2-苯基丙醛 生成 (R)-trifluoromethylphenylacetic acid
  参考文献：
  名称：

  Resolution and configuration of .alpha.-substituted phenylacetic acids

  摘要：

  DOI：

  10.1021/jo01284a035

文献信息

• Catalytic Asymmetric Synthesis of Macrocyclic (<i>E</i>)-Allylic Alcohols from ω-Alkynals via Intramolecular 1-Alkenylzinc/Aldehyde Additions
  作者：Wolfgang Oppolzer、Rumen N. Radinov、Emad El-Sayed

  DOI：10.1021/jo000463n

  日期：2001.7.1

  The omega-alkynals yielded macrocyclic (S)-allylic alcohols in a one-pot reaction sequence involving alkyne monohydroboration, boron to zinc transmetalation, and ((+)-DAIB)-catalyzed enantioselective intramolecular ring closure to the aldehyde function. A general study of this macrocyclization methodology is presented with respect to ligand type, size, and nature of the formed rings.

  ω-炔烃在一锅反应序列中生成大环（S）-烯丙基醇，涉及炔烃单氢硼化，硼到锌的金属转移和（（+）-DAIB）催化的对醛官能团的对映选择性分子内闭环。有关配体类型，大小和形成环的性质，对这种大环化方法进行了一般研究。
• [EN] NOVEL SUBSTITUTED AMINOTHIAZOLOPYRIMIDINEDIONE FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION<br/>[FR] NOUVELLE AMINOTHIAZOLOPYRIMIDINEDIONE SUBSTITUÉE POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION VIRALE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2017001307A1

  公开（公告）日：2017-01-05

  The present invention relates to compounds of formula (I), wherein R1 to R4 are as described herein, and their pharmaceutically acceptable salts, enantiomers or diastereomers thereof, and compositions including the compounds for use in the treatment of viral infections.

  本发明涉及式(I)的化合物，其中R1至R4如本文所述，以及其药学上可接受的盐、对映体或二异构体，以及包括该化合物的组合物，用于治疗病毒感染。
• 3,11b cis dihydrotetrabanezine for the treatment of psychoses
  申请人：Cambridge Laboratories (Ireland) Limited

  公开号：EP2050451A1

  公开（公告）日：2009-04-22

  The invention provides the use of 3, 11b-cis-dihydrotetrabenazine or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prophylaxis or treatment of schizophrenia and other psychoses.

  本发明提供了 3，11b-顺式二氢四苄肼或其药学上可接受的盐用于制造预防或治疗精神分裂症和其他精神病的药物。
• Optical rotatory dispersion studies. CXVII. Absolute configurational assignments of some .alpha.-substituted phenylacetic acids by circular dichroism measurements
  作者：Guenter Barth、Wolfgang Voelter、Harry S. Mosher、Edward Bunnenberg、Carl Djerassi

  DOI：10.1021/ja00707a024

  日期：1970.2
• Stereocontrolled and enantioselective synthesis of the branched 6-amino-4,6-deoxyheptopyranuronic acid component of amipurimycin
  作者：Philip Garner、Ji Uk Yoo、Ramakanth Sarabu、Vance O Kennedy、Wiley J Youngs

  DOI：10.1016/s0040-4020(98)00585-7

  日期：1998.8

  A stereocontrolled and enantioselective synthesis of the branched 6-amino-4,6-deoxyheptopyranuronic acid component of amipurimycin is reported. Key stages in the synthesis include the stereodivergent assembly of rile dihydropyrones 12 and 14 from serinal derivatives (S)-10 and (R)-10, elaboration of the tetrahydropyran ring to give 26 and 31, and finally, introduction of the cis-2-aminocyclopentanecarboxylic acid moiety to produce the diastereomeric peptides 28/29 and 32/33. (C) 1998 Elsevier Science Ltd. All rights reserved.