ethyl-(4-morpholin-4-yl-phenyl)-amine | 182804-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: ethyl-(4-morpholin-4-yl-phenyl)-amine
• 英文别名: N-ethyl-4-(morpholin-4-yl)aniline；N-ethyl-4-morpholin-4-ylaniline
• CAS: 182804-91-7
• 化学式: C₁₂H₁₈N₂O
• mdl: MFCD11161752
• 分子量: 206.288
• InChiKey: BJEWSJOAAMEMSP-UHFFFAOYSA-N

物化性质

• 沸点：
  372.0±37.0 °C(Predicted)
• 密度：
  1.093±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl-(4-morpholin-4-yl-phenyl)-amine 在 lithium aluminium tetrahydride 、 碳酸氢钠 、 乙酸乙酯 作用下， 以 乙醚 、 水 为溶剂， 反应 3.0h， 生成 Ethyl-methyl-(4-morpholin-4-yl-phenyl)-amine
  参考文献：
  名称：

  Preparation and Properties of N,N,N',N'-Tetrasubstituted 1,4-Benzenediamines.

  摘要：

  The synthesis of nine different N,N,N',N'-tetrasubstituted 1,4-benzenediamines is described. These compounds are of interest as mediators for glucose oxidase based biosensors and as donor molecules for conducting molecular solids. The electrochemical behaviour and the electronic absorption spectra have been investigated.

  DOI：

  10.3891/acta.chem.scand.50-1013
• 作为产物：
  描述：

  N-(4-morpholin-4-yl-phenyl)-acetamide 在 sodium tetrahydroborate 、 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以51%的产率得到ethyl-(4-morpholin-4-yl-phenyl)-amine
  参考文献：
  名称：

  Preparation and Properties of N,N,N',N'-Tetrasubstituted 1,4-Benzenediamines.

  摘要：

  The synthesis of nine different N,N,N',N'-tetrasubstituted 1,4-benzenediamines is described. These compounds are of interest as mediators for glucose oxidase based biosensors and as donor molecules for conducting molecular solids. The electrochemical behaviour and the electronic absorption spectra have been investigated.

  DOI：

  10.3891/acta.chem.scand.50-1013

文献信息

• [EN] MORPHOLINYLANILINOQUINAZO- LINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS<br/>[FR] DERIVES DE MORPHOLINYLANILINOQUINAZOLINE UTILISES EN TANT QU'AGENTS ANTIVIRAUX
  申请人：ARROW THERAPEUTICS LTD

  公开号：WO2005105761A1

  公开（公告）日：2005-11-10

  Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses, wherein R1, R2, R3 and R4 are as defined in the claims.

  发现式(Ia)化合物在抑制黄病毒科病毒复制方面具有活性，其中R1、R2、R3和R4如权利要求中所定义。
• [EN] THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS<br/>[FR] DERIVES DE THIOPHENE, LEUR FABRICATION ET LEUR UTILISATION COMME AGENTS PHARMACEUTIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005121134A1

  公开（公告）日：2005-12-22

  Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式（I）化合物，它们的药用盐、对映体形式、二对映异构体和拉克酸盐，上述化合物的制备，含有它们的药物以及其制造，以及上述化合物在控制或预防癌症等疾病中的应用。
• [EN] INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] INHIBITEURS DE L'HISTONE DEACETYLASE
  申请人：METHYLGENE INC

  公开号：WO2004069823A1

  公开（公告）日：2004-08-19

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  该发明涉及抑制组蛋白去乙酰化酶的技术。该发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。该发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS
  申请人：Fink Brian E.

  公开号：US20090048244A1

  公开（公告）日：2009-02-19

  The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明提供公式I化合物及其药学上可接受的盐。公式I化合物抑制生长因子受体的酪氨酸激酶活性，如HER1、HER2和HER4，因此使它们有用作抗增殖剂。公式I化合物也适用于治疗与通过生长因子受体进行信号转导途径相关的其他疾病。
• Sulfopyrroles
  申请人：Eberle Martin

  公开号：US20070060570A1

  公开（公告）日：2007-03-15

  The invention relates to compounds of formula (I) wherein R 1 represents aryl, aralkyl or heteroaryl, R 2 is aryl or heteroaryl and R 3 is aryl, heteroaryl or optionally substituted aminomethyl, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I) or of pharmaceutical compositions containing same.

  本发明涉及式(I)化合物，其中R1代表芳基、芳基烷基或杂芳基，R2为芳基或杂芳基，R3为芳基、杂芳基或可选取代的氨甲基；本发明还涉及合成这类化合物的方法，含有式(I)化合物的制药组合物，使用式(I)化合物制备用于治疗肿瘤和自身免疫性疾病的制药组合物，以及使用式(I)化合物或含有其的制药组合物治疗肿瘤和自身免疫性疾病的方法。