作者:Harry A. Albrecht、George Beskid、Nafsika H. Georgopapadakou、Dennis D. Keith、Frederick M. Konzelmann、David L. Pruess、Pamela L. Rossman、Chung Chen Wei、James G. Christenson
DOI:10.1021/jm00113a026
日期:1991.9
A series of cephalosporins has been prepared in which the 3'-position was linked to the nitrogen of the antibacterial quinolone ciprofloxacin through a carbamate function. Like the ester-linked and quaternary-linked dual-action cephalosporins reported earlier, these carbamate-linked compounds exhibited a broad antibacterial spectrum derived from both cephalosporin-like and quinolone-like activities, suggesting a dual mode of action. Studies to elucidate details of the mechanism of action have been inconclusive. Ciprofloxacin liberated as a consequence of bacterial enzyme-mediated reactions may contribute to the second mode of action, although some evidence indicates that the intact carbamate-linked bifunctional molecules may possess intrinsically both beta-lactam and quinolone activities.