4-(2-氨基乙氧基)苯甲酰胺 | 50714-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2-氨基乙氧基)苯甲酰胺
• 英文名称: 4-(2-Amino-ethoxy)-benzamide
• 英文别名: 1-Amino-2-(4-aminocarbonylphenoxy)ethan；2-(4-aminocarbonylphenoxy) ethylamine；4-(2-aminoethoxy)benzamide；2-(4-carbamoylphenoxy)-ethylamine；2-(4-carbamoylphenoxy)ethylamine；4-(2-Amino-ethoxy) benzamide
• CAS: 50714-69-7
• 化学式: C₉H₁₂N₂O₂
• mdl: MFCD10037136
• 分子量: 180.206
• InChiKey: MHIAMONBYDFGFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  78.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  4-(2-氨基乙氧基)苯甲酰胺 在 platinum(IV) oxide 盐酸 、 氢气 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 1-(3-acetamidophenoxy)-3-[2-(4-carbamoylphenoxy)ethylamino]propan-2-ol
  参考文献：
  名称：

  β-肾上腺素受体阻断剂。1.心脏选择性的1-芳氧基-3-（芳氧基烷基氨基）丙烷-2-醇。

  摘要：

  DOI：

  10.1021/jm00269a007
• 作为产物：
  描述：

  4-(2-溴-乙氧基)-苯甲酸乙酯 在 氨 作用下， 生成 4-(2-氨基乙氧基)苯甲酰胺
  参考文献：
  名称：

  5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro

  摘要：

  一组由以下式子表示的β-受体阻滞剂：##STR1## 其中R为##STR2##或##STR3##，以及其生理兼容的酸盐。这些β-受体阻滞剂是β-肾上腺素受体阻滞剂，可用于治疗心绞痛、心律失常和高血压。

  公开号：

  US04081447A1

文献信息

• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：HAPLOGEN GMBH

  公开号：WO2018050631A1

  公开（公告）日：2018-03-22

  The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.

  本发明涉及一般式（I）的新化合物，其中X和R1至R4基团的含义如描述和索赔中所述，制备这些化合物的方法以及它们作为治疗、预防或改善病毒感染的用途，以及用于治疗、预防或改善与PLA2G16相关的疾病的用途。
• Pyridyloxyalkyleneamino-phenoxy-propanol-2-compounds
  申请人：Ciba-Geigy Corporation

  公开号：US04027027A1

  公开（公告）日：1977-05-31

  Compounds of the formula ##STR1## WHEREIN Ar.sub.1 and Ar.sub.2 denote an optionally substituted aromatic hydrocarbon radical or a monocyclic, monoazacyclic or diazacyclic radical of aromatic character and Alk represents lower alkylene, or salts thereof, exhibit .beta.-receptor-blocking, blood pressure-lowering and vasodilatory effects and are useful for example in the treatment of arrythmias and angina pectoris, and as blood pressure-lowering agents.

  公式为##STR1##的化合物，其中Ar.sub.1和Ar.sub.2表示可选取代的芳香烃基或具有芳香性质的单环、单氮杂环或双氮杂环基团，Alk代表低碳烯基，或其盐，具有β-受体阻滞、降低血压和扩血管作用，例如在心律失常和心绞痛的治疗中以及作为降血压药物中有用。
• Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
  申请人：Boehringer Mannheim GmbH

  公开号：US04503067A1

  公开（公告）日：1985-03-05

  Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl; R.sub.2 is hydrogen, lower alkyl or arylalkyl; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen or lower alkyl, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--; X is a valency bond, --CH.sub.2 --, oxygen or sulfur; Ar is mono- or bicyclic aryl or pyridyl; R.sub.5 and R.sub.6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl; R.sub.5 and R.sub.6 together can represent methylenedioxy; and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.

  Carbazolyl-(4)-oxypropanolamine化合物的化学式为##STR1##其中R.sub.1是氢，较低的烷酰基或芳酰基；R.sub.2是氢，较低的烷基或芳基烷基；R.sub.3是氢或较低的烷基；R.sub.4是氢或较低的烷基，或者当X是氧时，R.sub.4与R.sub.5一起可以代表--CH.sub.2--O--；X是一个价键，--CH.sub.2--，氧或硫；Ar是单环或双环芳基或吡啶基；R.sub.5和R.sub.6分别选自氢，卤素，羟基，较低的烷基，氨基甲酰基，较低的烷氧基，芳基烷氧基，较低的烷基硫基，较低的烷基磺基；R.sub.5和R.sub.6一起可以代表亚甲二氧基；以及它们与生理上可接受的酸盐在治疗和预防循环和心脏疾病，例如高血压和心绞痛方面具有卓越的疗效。
• Phenoxypropanolamine therapeutic agents
  申请人：Pfizer Inc.

  公开号：US03961072A1

  公开（公告）日：1976-06-01

  A series of novel substituted phenoxypropylamine derivatives have been prepared by reacting the appropriate 1-phenoxy-2,3-epoxypropane compound with a suitable organic amine reagent. The resulting 1-phenoxy-3-alkylaminopropan-2-ols are useful in the field of chemotherapy as anti-angina agents. Preferred members include compounds having an acetamido group substituted on the phenyl ring of the phenoxy moiety. Alternate methods of preparation are also provided.

  一系列新型的取代苯氧丙胺衍生物已经通过将适当的1-苯氧基-2,3-环氧丙烷化合物与适当的有机胺试剂反应而制备出来。所得的1-苯氧基-3-烷基氨丙醇在化疗领域中作为抗心绞痛剂是有用的。首选成员包括在苯氧基部分的苯环上取代有乙酰胺基团的化合物。另外提供了其他制备方法。
• Syntheses and .BETA.-adrenergic blocking activities of carbostyril derivatives.
  作者：MICHIAKI TOMINAGA、HITOSHI TONE、KAZUYUKI NAKAGAWA、KAORUKO TAKADA、YO HOSHINO、KOZO WATANABE

  DOI：10.1248/cpb.29.2166

  日期：——

  Many 5-(3-amino-2-hydroxypropoxy)-8-alkoxy and acyloxy-3, 4-dihydrocarbostyrils and 5-(3-amino-2-hydroxypropoxy)-8-alkoxycarbostyrils were synthesized from 5, 8-dihydroxy-3, 4-dihydrocarbostyril, and their β-adrenergic blocking activities were examincd. Among them, 8-acetonyloxy-5-[3-(3, 4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3, 4-dihydrocarbostyril hydrochloride hydrate (IVh) was found to have potent β1-selective adrenergic blocking activity.

  许多5-(3-氨基-2-羟基丙氧基)-8-烷氧基和酰氧基-3,4-二氢羰基苯并吡喃和5-(3-氨基-2-羟基丙氧基)-8-烷氧基羰基苯并吡喃是由5,8-二羟基-3,4-二氢羰基苯并吡喃合成的，并对其β-肾上腺素阻断活性进行了研究。其中，8-乙酰氧基-5-[3-(3,4-二甲氧基苯乙胺基)-2-羟基丙氧基]-3,4-二氢羰基苯并吡喃盐酸盐水合物（IVh）被证明具有强效的β1选择性肾上腺素阻断活性。