5-carboxy-3-(2-chloro-4-(cyclohexyloxymethyl) benzyl)-2-methylindole | 245368-51-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-carboxy-3-(2-chloro-4-(cyclohexyloxymethyl) benzyl)-2-methylindole
• 英文别名: 3-[[2-chloro-4-(cyclohexyloxymethyl)phenyl]methyl]-2-methyl-1H-indole-5-carboxylic acid
• CAS: 245368-51-8
• 化学式: C₂₄H₂₆ClNO₃
• 分子量: 411.928
• InChiKey: PBRGVMUIRLYQHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  62.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-carboxy-3-(2-chloro-4-(cyclohexyloxymethyl) benzyl)-2-methylindole 、 1-戊烷磺酰胺 在 di-aza-bicycloundecene 、 N,N'-羰基二咪唑 作用下， 生成 3-(2-chloro-4-(cyclohexyloxymethyl)-benzyl)-2-methyl-5-(1-pentanesulfonylcarbamoyl)indole
  参考文献：
  名称：

  EP1070705

  摘要：

  公开号：

文献信息

• Compounds, Compositions and methods for insect control
  申请人：DeLong Anthony Mitchell

  公开号：US20050025795A1

  公开（公告）日：2005-02-03

  Rapidly acting compositions having vapor phase insecticidal activity comprise natural products or natural product-based materials. Further, these materials are non-petroleum based, are typically 100% biodegradable, and typically do not persist in the environment, unlike traditional pesticides. The compositions kill susceptible insects on contact in seconds, even the notoriously hardy peripleneta species. The compositions also kill insects behind cracks and crevices and when sprayed onto absorbent surfaces such as wood and plasterboard, where traditional contact insecticides work poorly or not at all. New methods of testing insecticides can be used to quantify these effects.

  快速作用的具有蒸汽相杀虫活性的组合物包括天然产品或基于天然产品的材料。此外，这些材料不基于石油，通常是100%可生物降解的，并且通常不会在环境中残留，不像传统杀虫剂。这些组合物能在接触时在几秒钟内杀死易感昆虫，甚至是以硬质蟑螂物种而著称的物种。这些组合物还能在裂缝和缝隙后杀死昆虫，并且当喷洒到吸收性表面（如木材和石膏板）时，传统的接触杀虫剂效果不佳或根本不起作用。可以使用新的杀虫剂测试方法来量化这些效果。
• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• Indole derivatives
  申请人：Yamasaki Noritsugu

  公开号：US20050171185A1

  公开（公告）日：2005-08-04

  A novel indole derivative or a salt thereof is provided, which is represented by the formula: wherein R 1 represents an aryl lower alkyl group, said aryl group may be substituted with one or more groups selected from the group consisting of a halogen atom, an aryl group, a heterocyclic group, an aryl lower alkyl group, an aryl lower alkenyl group, a halo-lower alkyl group, a lower cycloalkyl-lower alkoxy group, a lower cycloalkoxy-lower alkyl group, an aryl lower alkynyl group, an aryloxy lower alkyl group, an aryl lower alkoxy group, a lower alkylthio group, a lower alkoxy group, and an alkenyl group; and R 2 represents a lower alkyl group, a lower alkenyl group, an aryl group, or a heterocyclic group, each of which may be substituted with a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aryl group. The compound of the present invention has blood sugar level-depressing activity and PDE5-inhibiting activity, and is useful as medicine.

  本发明提供了一种新的吲哚衍生物或其盐，其表示为以下公式：其中，R1表示芳基低烷基基团，所述芳基基团可以用以下一种或多种基团替代：卤原子、芳基基团、杂环基团、芳基低烷基基团、芳基低烯基基团、卤代低烷基基团、低环烷基低烷氧基团、低环烷氧基低烷基基团、芳基低炔基基团、芳氧基低烷基基团、芳基低烷氧基团、低烷基硫基团、低烷氧基团和烯基基团；R2表示低烷基基团、低烯基基团、芳基基团或杂环基团，每个基团可以用氢原子、低烷基基团、低烯基基团或芳基基团替代。本发明化合物具有降低血糖水平的活性和PDE5抑制活性，并可用作药物。
• INDOLE DERIVATIVES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1070705A1

  公开（公告）日：2001-01-24

  Novel indole derivatives represented by formula (I) or salts thereof, wherein R1 is aryl-substituted lower alkyl in which the aryl may be substituted by at least one member selected among halogen atoms, aryls, heterocyclic groups, aryl-substituted lower alkyls, aryl-substituted lower alkenyls, lower haloalkyls, (lower cycloalkyl)-substituted lower alkyloxys, (lower cycloalkyloxy)-substituted lower alkyls, aryl-substituted lower alkynyls, aryloxy-substituted lower alkyls, aryl-substituted lower alkyloxys, lower alkylthios, lower alkyloxys, and alkenyls; and R2 is a lower alkyl, lower alkenyl, aryl, or heterocyclic group optionally substituted by halogeno, lower alkyl, lower alkenyl, or aryl. These compounds have a hypoglycemic activity and a PDE5 inhibitory activity and are useful as a drug.

  低级卤代烷基、（低级环烷基）取代的低级烷氧基、（低级环烷氧基）取代的低级烷基、芳基取代的低级炔基、芳氧基取代的低级烷基、芳基取代的低级烷氧基、低级烷硫基、低级烷氧基和烯基；R2 是可选被卤素、低级烷基、低级烯基或芳基取代的低级烷基、低级烯基、芳基或杂环基团。这些化合物具有降血糖活性和 PDE5 抑制活性，可用作药物。
• COMPOSITIONS AND METHODS FOR INSECT CONTROL
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1397042A1

  公开（公告）日：2004-03-17