N-(4-nitrophenyl)-2-(quinolin-8-ylamino)acetamide | 1261166-62-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-nitrophenyl)-2-(quinolin-8-ylamino)acetamide
• CAS: 1261166-62-4
• 化学式: C₁₇H₁₄N₄O₃
• 分子量: 322.323
• InChiKey: PWOIRPYLNSVKTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  99.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(4-nitrophenyl)-2-(quinolin-8-ylamino)acetamide 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 以46%的产率得到N-(4-nitrophenyl)-N'-quinolin-8-ylethane-1,2-diamine
  参考文献：
  名称：

  Fine tuning of receptor polarity for the development of selective naked eye anion receptor

  摘要：

  We designed and synthesized new anion receptors 1, 2, and 3, which have different N-H polarity. According to their N-H polarities, these receptors showed different selectivities for the anions they were interacting with. The difference of selectivity could be easily recognized from their color change during recognition events. Therefore, fine tuning of receptor polarity could be a good strategy for the designing of a selective anion receptor and made it possible to develop a selective naked eye anion receptor. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.081
• 作为产物：
  描述：

  8-氨基喹啉 、 N-(4-nitrophenyl)bromoacetamide 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以33.7%的产率得到N-(4-nitrophenyl)-2-(quinolin-8-ylamino)acetamide
  参考文献：
  名称：

  Novel receptors with quinoline and amide moieties for the biologically important ions

  摘要：

  New chromogenic anion receptors 2 and 4 utilizing quinoline and nitrophenyl groups as signaling groups were synthesized. In these receptors, amide and amine groups made strong multiple hydrogen interactions with anions. The receptors 2 and 4 bind anions with a selectivity of F- > CN- > CH3CO2- and proved to be an efficient naked-eye detector for the fluoride and cyanide ion. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.10.058