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N-(2-Benzoyl-4-nitro-phenyl)-acetamide | 41019-22-1

中文名称
——
中文别名
——
英文名称
N-(2-Benzoyl-4-nitro-phenyl)-acetamide
英文别名
2-acetylamino-5-nitrobenzophenone;2-Acetamino-5-nitrobenzophenon;2-Acetylamino-5-nitro-benzophenon;2-Acetamido-5-nitro-benzophenon;acetic acid-(2-benzoyl-4-nitro-anilide);Essigsaeure-(2-benzoyl-4-nitro-anilid);2'-benzoyl-4'-nitroacetanilide;N-(2-Benzoyl-4-nitrophenyl)acetamide
N-(2-Benzoyl-4-nitro-phenyl)-acetamide化学式
CAS
41019-22-1
化学式
C15H12N2O4
mdl
——
分子量
284.271
InChiKey
PGXLULGZZOZXRW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3
  • 重原子数:
    21
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.07
  • 拓扑面积:
    92
  • 氢给体数:
    1
  • 氢受体数:
    4

安全信息

  • 海关编码:
    2924299090

SDS

SDS:f53475388a77d86aef534ab261efe387
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上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    N-(2-Benzoyl-4-nitro-phenyl)-acetamide盐酸 作用下, 以 乙醇 为溶剂, 反应 7.0h, 生成 3-acetyl-6-nitro-4-phenylquinolin-2(1H)-one
    参考文献:
    名称:
    作为选择性磷酸二酯酶2抑制剂的喹啉酮类化合物及其制备方法
    摘要:
    本发明属于化学医药领域,具体涉及作为选择性磷酸二酯酶2抑制剂的喹啉酮类化合物及其制备方法。本发明提供了一种喹啉酮类化合物,化合物通式如式(A)所示,该化合物该对PDE2具有高强度的抑制作用,同时对其他PDE亚型具有高选择性。本发明同时提供了此类衍生物的制备方法,科学合理、简单易行。本发明所述的喹啉酮类化合物的用途是制备用于治疗记忆和认知功能障碍、神经退行性疾病及心血管类疾病的药物。
    公开号:
    CN112390750B
  • 作为产物:
    参考文献:
    名称:
    Atkinson et al., Journal of the Chemical Society, 1954, p. 165,170
    摘要:
    DOI:
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文献信息

  • Micellar catalysis of organic reactions. XIV. Hydrolysis of some 1,4-Benzodiazepin-2-one drugs in acidic solution
    作者:TJ Broxton、T Ryan、SR Morrison
    DOI:10.1071/ch9841895
    日期:——

    Kinetic studies of the acidic hydrolysis of diazepam and nitrazepam were carried out in the presence of micelles of sodium dodecyl sulfate (sds). The hydrolysis of diazepam was shown to occur with biphasic kinetics. This is consistent with initial hydrolysis of the azomethine bond followed by very slow hydrolysis of the amide bond as found for hydrolysis in aqueous solution. Nitrazepam, however, was found to decompose with monophasic kinetics consistent with initial amide hydrolysis. Reactions involving the hydrolysis of the azomethine bond were shown to be independent of acid concentration and subject to inhibition by micelles of sds. Reactions involving amide hydrolysis were shown to be first order in acid concentration and subject to micellar catalysis. The mechanistic change for the hydrolysis of nitrazepam on transfer from water (initial azomethine cleavage) to micelles of sds (initial amide cleavage), was presumably the result of the inhibition of azomethine hydrolysis and the catalysis of amide hydrolysis by the micelles.

    地西泮和硝西泮酸性水解的动力学研究 对地西泮和硝西泮的酸性水解进行了动力学研究。 在十二烷基硫酸钠胶束(sds 硫酸钠胶束(sds)的存在下进行了地西泮和硝西泮的酸性水解动力学研究。结果表明,地西泮的水解是以双相动力学方式进行的。 发生双相动力学反应。这与 氮甲基键水解,然后是非常缓慢的酰胺键水解。 酰胺键的水解速度非常缓慢,这与水溶液中的水解过程一致。然而,研究发现硝西泮的分解动力学是单相的,与最初的酰胺键水解一致。 水解。涉及偶氮甲基键水解的反应 键的水解反应不受酸浓度的影响,并受 的胶束抑制。涉及 酰胺水解的反应与酸浓度呈一阶关系,并受胶束催化。 胶束催化作用。硝西泮从水(最初的偶氮甲胺裂解)转移到 sds 胶束(最初的酰胺裂解)时的水解机理变化为 (初始酰胺裂解)时,硝西泮的水解机理发生了变化,这可能是偶氮甲 碱水解受到抑制和胶束催化酰胺水解的结果。 的结果。
  • [EN] THIOUREA INHIBITORS OF HERPES VIRUSES<br/>[FR] THIO-UREES INHIBITRICES DES VIRUS DE L'HERPES
    申请人:AMERICAN HOME PROD
    公开号:WO2000034268A1
    公开(公告)日:2000-06-15
    Compounds of formula (I) wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR6, or is absent; G is aryl or heteroaryl; and X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
    化合物的式子(I),其中A是杂环芳基;R9-R12独立地是氢,1到4个碳原子的烷基,1到4个碳原子的全氟烷基,卤素,1到4个碳原子的烷氧基,或氰基,或者R9和R10或R11和R12可以结合成5到7个碳原子的芳基;W是O,NR6,或不存在;G是芳基或杂环芳基;X是键,-NH,1到6个碳原子的烷基,1到6个碳原子的烯基,1到6个碳原子的烷氧基,1到6个碳原子的硫代烷基,1到6个碳原子的烷基氨基,或(CH)J;J是1到6个碳原子的烷基,3到7个碳原子的环烷基,苯基或苄基;n是1到6的整数;或其药用盐,用于治疗与疱疹病毒相关的疾病,包括人类巨细胞病毒,单纯疱疹病毒,埃普斯坦-巴尔病毒,水痘-带状疱疹病毒,人类疱疹病毒6和7,以及卡波西疱疹病毒。
  • [EN] THIOUREA INHIBITORS OF HERPES VIRUSES<br/>[FR] INHIBITEURS DE THIO-UREE DES VIRUS DE L'HERPES
    申请人:AMERICAN HOME PROD
    公开号:WO2000034269A1
    公开(公告)日:2000-06-15
    Compounds of formula (1) wherein, R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6,-COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) or W-Y-(CH2)n-Z; or R2 and R3 or R3 and R4, taken together from a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl; W is O, NR6, or is absent; Y is -(CO)- or -(CO2)-, or is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -CO2R6, COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) or phenyl; G is aryl or heteroaryl; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpes viruses -6 and -7, and Kaposi herpesvirus.
    式子(1)的化合物,其中R1-R5独立地选择自氢、1至6个碳原子的烷基、2至6个碳原子的烯基、2至6个碳原子的炔基、1至6个碳原子的全氟烷基、3至10个碳原子的环烷基、3至10个碳原子的杂环烷基、芳基、杂芳基、卤素、-CN、-NO2、-CO2R6、-COR6、-OR6、-SR6、-SOR6、-SO2R6、-CONR7R8、-NR6N(R7R8)、-N(R7R8)或W-Y-(CH2)n-Z;或R2和R3或R3和R4,一起来自3至7个成员的杂环烷基或3至7个成员的杂芳基;R6和R7独立地为氢、1至6个碳原子的烷基、1至6个碳原子的全氟烷基或芳基;R8为氢、1至6个碳原子的烷基、1至6个碳原子的全氟烷基、3至10个碳原子的环烷基、3至10个成员的杂环烷基、芳基或杂芳基,或R7和R8一起可以形成3至7个成员的杂环烷基;A为杂芳基;W为O、NR6或不存在;Y为-(CO)-或-(CO2)-,或不存在;Z为1至4个碳原子的烷基、-CN、-CO2R6、COR6、-CONR7R8、-OCOR6、-NR6COR7、-OCONR6、-OR6、-SR6、-SOR6、-SO2R6、SR6N(R7R8)、-N(R7R8)或苯基;G为芳基或杂芳基;X为键、-NH、1至6个碳原子的烷基、1至6个碳原子的烯基、1至6个碳原子的烷氧基、1至6个碳原子的硫代烷基、1至6个碳原子的烷基氨基或(CH)J;J为1至6个碳原子的烷基、3至7个碳原子的环烷基、苯基或苄基; n为1至6的整数;在治疗与疱疹病毒相关的疾病中有用,包括人类巨细胞病毒、单纯疱疹病毒、EB病毒、水痘-带状疱疹病毒、人类疱疹病毒-6和-7以及卡波西疱疹病毒。
  • Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
    申请人:American Home Products Corporation
    公开号:US20010039348A1
    公开(公告)日:2001-11-08
    Compounds having the formula: 1 wherein R 1 -R 5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO 2 , —CO 2 R 6 , —COR 6 , —OR 6 , —SR 6 , —SOR 6 , —SO 2 R 6 , —CONR 7 R 8 , —NR 6 N(R 7 R 8 ), —N(R 7 R 8 ) or W-Y-(CH 2 ) n -Z provided that at least one of R 1 -R 5 is not hydrogen; or R 1 and R 2 or R 3 and R 4 , taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R 6 and R 7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R 8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R 7 and R 8 , taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR 6 , or is absent; Y is —(CO)— or —(CO 2 )—, or is absent; Z is alkyl of 1 to 4 carbon atoms, —CN, —CO 2 R 6 , COR 6 , —CONR 7 R 8 , —OCOR 6 , —NR 6 COR 7 , —OCONR 6 , —OR 6 , —SR 6 , —SOR 6 , —SO 2 R 6 , SR6N(R7R8), —N(R 7 R 8 ) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
    化合物的化学式为1,其中R1-R5独立选择自氢、1到6个碳原子的烷基、2到6个碳原子的烯基、2到6个碳原子的炔基、1到6个碳原子的全卤烷基、3到10个碳原子的环烷基、3到10个碳成员的杂环烷基、芳基、杂芳基、卤素、-CN、-NO2、-CO2R6、-COR6、-OR6、-SR6、-SOR6、-SO2R6、-CONR7R8、-NR6N(R7R8)、-N(R7R8)或W-Y-(CH2)n-Z,其中至少一个R1-R5不是氢;或R1和R2或R3和R4,一起形成3到7个成员的杂环烷基或3到7个成员的杂芳基;R6和R7独立地为氢、1到6个碳原子的烷基、1到6个碳原子的全卤烷基或芳基;R8为氢、1到6个碳原子的烷基、1到6个碳原子的全卤烷基、3到10个碳原子的环烷基、3到10个成员的杂环烷基、芳基或杂芳基,或R7和R8一起形成3到7个成员的杂环烷基;W为O、NR6或不存在;Y为-CO-或-CO2-,或不存在;Z为1到4个碳原子的烷基、-CN、-CO2R6、COR6、-CONR7R8、-OCOR6、-NR6COR7、-OCONR6、-OR6、-SR6、-SOR6、-SO2R6、SR6N(R7R8)、-N(R7R8)或苯基;G为芳基或融合的双环杂芳基;X为键、-NH、1到6个碳原子的烷基、1到6个碳原子的烯基、1到6个碳原子的烷氧基、1到6个碳原子的硫代烷基、1到6个碳原子的烷基氨基或(CH)J;J为1到6个碳原子的烷基、3到7个碳原子的环烷基、苯基或苄基;n为1到6的整数。该化合物可用于治疗与疱疹病毒相关的疾病,包括人类巨细胞病毒、单纯疱疹病毒、EB病毒、水痘-带状疱疹病毒、人类疱疹病毒-6和-7以及卡波西疱疹病毒。
  • Diaminopyridine-containing thiourea inhibitors of herpes viruses
    申请人:American Home Products Corporation
    公开号:US20030036653A1
    公开(公告)日:2003-02-20
    Compounds of the formula 1 R 1 -R 5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO 2 , —CO 2 R 6 , —COR 6 , —OR 6 , —SR 6 , —SOR 6 , —SO 2 R 6 , —CONR 7 R 8 , —NR 6 N(R 7 R 8 ), —(R 7 R 8 ) or W—Y—(CH 2 )—Z; or R 2 and R 3 or R 3 and R 4 , taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R 6 and R 7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R 8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R 7 and R 8 , taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl;
    公式中的化合物1R1-R5独立选择自氢、1至6个碳原子的烷基、2至6个碳原子的烯基、2至6个碳原子的炔基、1至6个碳原子的全卤烷基、3至10个碳原子的环烷基、3至10个碳原子的杂环烷基、芳基、杂芳基、卤素、—CN、—NO2、—CO2R6、—COR6、—OR6、—SR6、—SOR6、—SO2R6、—CONR7R8、—NR6N(R7R8)、—(R7R8)或W—Y—(CH2)—Z;或R2和R3或R3和R4在一起形成3至7个成员的杂环烷基或3至7个成员的杂芳基;R6和R7独立地为氢、1至6个碳原子的烷基、1至6个碳原子的全卤烷基或芳基;R8是氢、1至6个碳原子的烷基、1至6个碳原子的全卤烷基、3至10个碳原子的环烷基、3至10个成员的杂环烷基、芳基或杂芳基,或R7和R8在一起可以形成3至7个成员的杂环烷基;A是杂芳基;
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(βS)-β-氨基-4-(4-羟基苯氧基)-3,5-二碘苯甲丙醇 (S)-(-)-7'-〔4(S)-(苄基)恶唑-2-基]-7-二(3,5-二-叔丁基苯基)膦基-2,2',3,3'-四氢-1,1-螺二氢茚 (S)-盐酸沙丁胺醇 (S)-3-(叔丁基)-4-(2,6-二甲氧基苯基)-2,3-二氢苯并[d][1,3]氧磷杂环戊二烯 (S)-2,2'-双[双(3,5-三氟甲基苯基)膦基]-4,4',6,6'-四甲氧基联苯 (S)-1-[3,5-双(三氟甲基)苯基]-3-[1-(二甲基氨基)-3-甲基丁烷-2-基]硫脲 (R)富马酸托特罗定 (R)-(-)-盐酸尼古地平 (R)-(+)-7-双(3,5-二叔丁基苯基)膦基7''-[((6-甲基吡啶-2-基甲基)氨基]-2,2'',3,3''-四氢-1,1''-螺双茚满 (R)-3-(叔丁基)-4-(2,6-二苯氧基苯基)-2,3-二氢苯并[d][1,3]氧杂磷杂环戊烯 (R)-2-[((二苯基膦基)甲基]吡咯烷 (N-(4-甲氧基苯基)-N-甲基-3-(1-哌啶基)丙-2-烯酰胺) (5-溴-2-羟基苯基)-4-氯苯甲酮 (5-溴-2-氯苯基)(4-羟基苯基)甲酮 (5-氧代-3-苯基-2,5-二氢-1,2,3,4-oxatriazol-3-鎓) (4S,5R)-4-甲基-5-苯基-1,2,3-氧代噻唑烷-2,2-二氧化物-3-羧酸叔丁酯 (4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮 (4-丁氧基苯甲基)三苯基溴化磷 (3aR,8aR)-(-)-4,4,8,8-四(3,5-二甲基苯基)四氢-2,2-二甲基-6-苯基-1,3-二氧戊环[4,5-e]二恶唑磷 (2Z)-3-[[(4-氯苯基)氨基]-2-氰基丙烯酸乙酯 (2S,3S,5S)-5-(叔丁氧基甲酰氨基)-2-(N-5-噻唑基-甲氧羰基)氨基-1,6-二苯基-3-羟基己烷 (2S,2''S,3S,3''S)-3,3''-二叔丁基-4,4''-双(2,6-二甲氧基苯基)-2,2'',3,3''-四氢-2,2''-联苯并[d][1,3]氧杂磷杂戊环 (2S)-(-)-2-{[[[[3,5-双(氟代甲基)苯基]氨基]硫代甲基]氨基}-N-(二苯基甲基)-N,3,3-三甲基丁酰胺 (2S)-2-[[[[[[((1R,2R)-2-氨基环己基]氨基]硫代甲基]氨基]-N-(二苯甲基)-N,3,3-三甲基丁酰胺 (2-硝基苯基)磷酸三酰胺 (2,6-二氯苯基)乙酰氯 (2,3-二甲氧基-5-甲基苯基)硼酸 (1S,2S,3S,5S)-5-叠氮基-3-(苯基甲氧基)-2-[(苯基甲氧基)甲基]环戊醇 (1-(4-氟苯基)环丙基)甲胺盐酸盐 (1-(3-溴苯基)环丁基)甲胺盐酸盐 (1-(2-氯苯基)环丁基)甲胺盐酸盐 (1-(2-氟苯基)环丙基)甲胺盐酸盐 (-)-去甲基西布曲明 龙胆酸钠 龙胆酸叔丁酯 龙胆酸 龙胆紫 龙胆紫 齐达帕胺 齐诺康唑 齐洛呋胺 齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯 齐培丙醇 齐咪苯 齐仑太尔 黑染料 黄酮,5-氨基-6-羟基-(5CI) 黄酮,6-氨基-3-羟基-(6CI) 黄蜡,合成物 黄草灵钾盐