Methyl I+/--[[(phenylmethoxy)carbonyl]amino]benzenebutanoate | 134306-45-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl I+/--[[(phenylmethoxy)carbonyl]amino]benzenebutanoate
• 英文别名: methyl 4-phenyl-2-(phenylmethoxycarbonylamino)butanoate
• CAS: 134306-45-9
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.38
• InChiKey: SCBBQEIEMVKRNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (1-Phenethyl-buta-2,3-dienyl)-carbamic acid benzyl ester 在 臭氧 作用下， 以 二氯甲烷 为溶剂， 生成 Methyl I+/--[[(phenylmethoxy)carbonyl]amino]benzenebutanoate
  参考文献：
  名称：

  A convenient procedure for the preparation of α-aminoallenes using a three-component reaction of aldehyde, carbamate and propargylsilane

  摘要：

  A three-component reaction is described using an aldehyde, a carbamate and trimethylpropargylsilane in the presence of a Lewis acid for the production in moderate to good yield of alpha-allenyl amines. The reaction is applicable to aromatic or aliphatic aldehydes, The obtained alpha-aminoallenes are transformed into Delta(3)-pyrrolidines or amino acids by Using the reactivity of the cumulene function. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00056-4

文献信息

• Zinc promoted simple and convenient synthesis of carbamates: An easy access for amino group protection
  作者：J.S. Yadav、Gondi Sudershan Reddy、M.Muralidhar Reddy、H.M. Meshram

  DOI：10.1016/s0040-4039(98)00464-x

  日期：1998.5

  Synthesis of alkyl, aryl, heterocyclic, carbohydrate and amino acid carbamates is described. The protection of the amino group in the presence of other functionality in amino acids demonstrates the importance of this method. (C) 1998 Elsevier Science Ltd. All rights reserved.
• A convenient procedure for the preparation of α-aminoallenes using a three-component reaction of aldehyde, carbamate and propargylsilane
  作者：Manuella Billet、Angèle Schoenfelder、Philippe Klotz、André Mann

  DOI：10.1016/s0040-4039(02)00056-4

  日期：2002.2

  A three-component reaction is described using an aldehyde, a carbamate and trimethylpropargylsilane in the presence of a Lewis acid for the production in moderate to good yield of alpha-allenyl amines. The reaction is applicable to aromatic or aliphatic aldehydes, The obtained alpha-aminoallenes are transformed into Delta(3)-pyrrolidines or amino acids by Using the reactivity of the cumulene function. (C) 2002 Elsevier Science Ltd. All rights reserved.