phenylethylglyoxal | 56485-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenylethylglyoxal
• 英文别名: 2-oxo-4-phenylbutanal；β-Phenaethyl-glyoxal；2-Phenylethyl-diazomethylketon；Phenaethylglyoxal；1³.1⁴-Dioxo-1-butyl-benzol；γ.δ-Dioxo-α-phenyl-butan；2-oxo-4-phenyl-butyraldehyde；phenyl-1,2-butanedione；2-Phenylethyl-glyoxal
• CAS: 56485-07-5
• 化学式: C₁₀H₁₀O₂
• 分子量: 162.188
• InChiKey: VRMKYLJEQZBUBG-UHFFFAOYSA-N

物化性质

• 沸点：
  115-116 °C(Press: 10 Torr)
• 密度：
  1.0019 g/cm3(Temp: 15.8 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  phenylethylglyoxal 在 sodium hydroxide 作用下， 生成 2-羟基-4-苯基丁酸
  参考文献：
  名称：

  Density and Water Exchange-Dependent Growth and Survival of Litopenaeus setiferus Postlarvae

  摘要：

  AbstractThis present study was designed to investigate the effects of stocking density and water exchange on the growth rate, survival and performance index of L. setiferus postlarvae under controlled laboratory conditions. The experiment was done with postlarvae (PL10 to PL40) at densities of 50, 150, 250 and 350 shrimp/m2 and various different water exchanges rate per day (0, 6, 12 and 18%). The maximum growth rate was obtained for shrimp with 12% water exchange per day at all densities. A reduction of the maximum growth rate was observed in relation to density with the highest values in shrimp stocked in a density of 50 and 150 shrimp/m2 (mean value of 0.53 mg/d) and the lowest in shrimp stocked in a density of 350 shrimp/m2 (0.24 mg/d). The multiple regression equation obtained to relate performance index (growth rate* survival : PI), shrimp density (X1) and water exchange (X2) was: PI = 0.31 + (0.001) X1+ 0.039 X2+ 2.28 × 10−6 X12+ (−0.0017) X22+ (0.000026)X1X2,R2= 0.78; P > 0.03. According to this equation the optimum shrimp density‐water exchange comhination was between 5 to 12% of water exchange at stocking density of between 50 and 150 shrimp/m2. Salinity, ammonia‐N and nitrite‐N increased according to the time spent in tanks without water exchange. With no (0%) water exchange, water quality parameters measured were outside the optimum for L. setiferus postlarvae. The use of optimum density and water exchange in a nursery system for L. setiferus with optimum variables established is proposed.

  DOI：

  10.1111/j.1749-7345.2001.tb01091.x
• 作为产物：
  描述：

  4-苯基-1-丁炔 在 potassium permanganate 、 碳酸氢钠 、 magnesium sulfate 作用下， 以 水 、 丙酮 为溶剂， 反应 4.0h， 生成 phenylethylglyoxal
  参考文献：
  名称：

  取代的乙烷-1,2-二酮对哺乳动物羧酸酯酶抑制的要求

  摘要：

  羧酸酯酶 (CE) 是人类和动物组织中普遍存在的酶，负责异生物质的代谢。这包括许多天然产品，以及许多临床使用的药物。因此，这些药剂的活性可能取决于 CE 表达的水平和位置。我们最近发现 benzil 是哺乳动物 CE 的有效抑制剂，在这项研究中，我们评估了这种化合物的类似物抑制这些酶的能力。分析了三种不同类别的分子：一种含有不同的原子，靠近羰基碳原子和苯环 [PhXC(O)C(O)XPh，其中 X = CH 2、CHBr、N、S或O]；第二个包含一组烷基 1,2-二酮，表明烷基链长度增加；第三个由一系列 1-苯基-2-烷基-1,2-二酮组成。一般来说，对于前一系列分子，杂原子导致抑制效力的丧失（当 X = N 时），或化合物转化为酶的底物（当 X = S 或 O 时）。然而，包含溴化亚甲基原子导致有效的 CE 抑制。随后对烷基二酮 [RC(O)C(O)R，其中 R 的范围从 CH 3到 C

  DOI：

  10.1016/j.bmc.2011.06.012

文献信息

• Ketosulfonyl indoles in the regiodefined synthesis of tryptophols and related indole derivatives
  作者：Alessandro Palmieri、Marino Petrini

  DOI：10.1039/c2ob25056j

  日期：——

  Reduction of ketosulfonyl indoles with sodium borohydride provides a ready entry to tryptophols in a regiocomplementary fashion with respect to the traditional oxirane ring-opening by indoles under Friedel–Crafts conditions. Compared to traditional β-ketosulfones, ketosulfonyl indoles show a peculiar behavior since they undergo a Lewis acid promoted elimination of the arylsulfonyl group allowing the

  还原酮磺酰基吲哚 硼氢化钠相对于弗里德尔-克拉夫茨条件下的吲哚类化合物传统的环氧乙烷开环，可以以区域互补的方式方便地使用三酚。与传统的β-酮砜相比，酮磺酰基吲哚显示出独特的行为，因为它们经历路易斯酸促进了芳基磺酰基的消除，从而可以制备吲哚基取代的1,4-二羰基衍生物。
• Synthesis of α-keto aldehydes <i>via</i> selective Cu(<scp>i</scp>)-catalyzed oxidation of α-hydroxy ketones
  作者：Shasha Zheng、Wietse Smit、Anke Spannenberg、Sergey Tin、Johannes G. de Vries

  DOI：10.1039/d2cc00773h

  日期：——

  An efficient approach to synthesize α-keto aldehydes was established through selective oxidation of α-hydroxy ketones catalyzed by Cu(I) using oxygen as oxidant. A wide array of α-keto aldehydes was prepared with isolated yields of up to 87%. The potential utilization of this reaction was evaluated by gram-scale reactions and synthetic applications.

  通过以氧气为氧化剂，Cu( I )催化α-羟基酮选择性氧化，建立了一种合成α-酮醛的有效方法。制备了多种 α-酮醛，分离产率高达 87%。该反应的潜在利用通过克级反应和合成应用进行了评估。
• Novel agents for replacement of NAD+/NADH system in enzymatic reactions
  申请人：——

  公开号：US20030022266A1

  公开（公告）日：2003-01-30

  Novel agents acting as co-factors for replacement of NAD(P) + /NAD(P)H co-enzyme systems in enzymatic oxido-reductive reactions. Agents mimicking the action of NAD(P) + /NAD(P)H system in enzymatic oxidation/reduction of substrates into reduced or oxidized products. A method for selection and preparation of the mimicking agents for replacement of NAD(P) + /NAD(P)H system and a device comprising co-factors for replacement of NAD(P) + /NAD(P)H system.

  新型药物作为辅因子，用于替代酶促氧化还原反应中的NAD(P)H/NAD(P)+辅酶系统。这些药物模仿NAD(P)H/NAD(P)+辅酶系统的作用，将底物在酶促氧化还原反应中转化为还原或氧化产物。本发明涉及一种选择和制备模仿剂以替代NAD(P)H/NAD(P)+辅酶系统的方法，以及包含辅因子的装置以替代NAD(P)H/NAD(P)+辅酶系统。
• Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
  申请人：UNIVERSITY OF MIAMI

  公开号：EP0048159A2

  公开（公告）日：1982-03-24

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula Wherein X = X, O or NR9, R4 and R5 form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 X = X、O 或 NR9，R4 和 R5 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自已公开的各种基团。
• Imidazolidyl macrolides having immunosuppressive activity
  申请人：MERCK & CO. INC.

  公开号：EP0536896A1

  公开（公告）日：1993-04-14

  Imidazolidyl macrolides of the general structural Formula I: have been prepared from suitable precursors by alkylation and/or arylation at C-3˝ and/or C-4˝ of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

  一般结构式 I 的咪唑烷基大环内酯： 由合适的前体通过环己基环的 C-3˝ 和/或 C-4˝ 烷基化和/或芳基化制备而成。这些大环内酯类免疫抑制剂可用于哺乳动物宿主治疗自身免疫性疾病、传染性疾病、预防外来器官移植的排斥反应和/或相关的痛苦、疾病和病症。