8-chloro-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine | 1379508-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-chloro-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine
• 英文别名: 8-chloro-2-[2-(1-hydroxycyclohexyl)ethyn-1-yl]-N⁹-propargyladenine；8-chloro-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N9-propargyladenine；1-[2-(6-amino-8-chloro-9-prop-2-ynylpurin-2-yl)ethynyl]cyclohexan-1-ol
• CAS: 1379508-91-4
• 化学式: C₁₆H₁₆ClN₅O
• 分子量: 329.789
• InChiKey: SOZROBWZKBVOPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2',3',5'-三-O-乙酰-6-氯-2-碘嘌呤核苷 在 吡啶 、 盐酸 、 bis-triphenylphosphine-palladium(II) chloride 、 N-氯代丁二酰亚胺 、 copper(l) iodide 、 水 、 potassium acetate 、 potassium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 64.0h， 生成 8-chloro-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine
  参考文献：
  名称：

  8-Substituted 2-alkynyl-N9-propargyladenines as A2A adenosine receptor antagonists

  摘要：

  Structure-activity relationships of 2-alkynyladenine derivatives were explored by varying substituents at the 9-, 8- and 2-positions of the purine moiety in order to optimize A(2A) adenosine receptor antagonist activity in vitro. A propargyl group at the 9-position was found to be important for A2A antagonist activity, and the introduction of a halogen, aryl, or heteroaryl at the 8-position further enhanced activity. A series of 8-substituted 2-alkynyl-N-9-propargyladenine derivatives exhibited potent antagonist activity, with IC50 values in the low nM range. Compound 4a from this series was found to be orally active at a dose of 3 mg/kg in a mouse catalepsy model and a 6-hydroxydopamine-lesioned rat model of Parkinson's disease. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.04.041

文献信息

• NOVEL 2-ALKYNYL-N9-PROPARGYLADENINE AND MEDICINAL USE THEREOF
  申请人：Endo Kazuki

  公开号：US20130245046A1

  公开（公告）日：2013-09-19

  In the present invention, a novel 2-alkynyl-N9-propargyladenine represented by formula (I) wherein R 1 represents a halogen atom, a furyl group, or a triazolyl group; R 2 and R 3 each represents a hydrogen atom or a C1-8 alkyl group, or form a cycloalkyl group by bonding to each other; and X represents a hydrogen atom or a hydroxyl group, or a pharmaceutically acceptable salt thereof, has a stronger and longer-lasting effect as a therapeutic agent for Parkinsonian syndromes.

  本发明涉及一种新型2-炔基-N9-丙炔基腺嘌呤，其化学式为（I），其中R1代表卤素原子、呋喃基或三唑基；R2和R3分别代表氢原子或C1-8烷基，或通过相互结合形成环烷基；X代表氢原子或羟基，或其药学上可接受的盐。该化合物作为帕金森综合症治疗剂具有更强和更持久的效果。
• 2-alkynyl-N9-propargyladenine and medicinal use thereof
  申请人：Endo Kazuki

  公开号：US08791126B2

  公开（公告）日：2014-07-29

  In the present invention, a novel 2-alkynyl-N9-propargyladenine represented by formula (I) wherein R1 represents a halogen atom, a furyl group, or a triazolyl group; R2 and R3 each represents a hydrogen atom or a C1-8 alkyl group, or form a cycloalkyl group by bonding to each other; and X represents a hydrogen atom or a hydroxyl group, or a pharmaceutically acceptable salt thereof, has a stronger and longer-lasting effect as a therapeutic agent for Parkinsonian syndromes.

  本发明提供了一种新型2-炔基-N9-丙炔基腺嘌呤，其化学式表示为(I)，其中R1代表卤素原子、呋喃基或三唑基；R2和R3各代表氢原子或C1-8烷基，或通过彼此结合形成环状烷基；X代表氢原子或羟基，或其药学上可接受的盐。该化合物作为帕金森综合症治疗剂具有更强的且持久的效果。
• US8791126B2
  申请人：——

  公开号：US8791126B2

  公开（公告）日：2014-07-29
• 8-Substituted 2-alkynyl-N9-propargyladenines as A2A adenosine receptor antagonists
  作者：Kazuki Endo、Kazuki Deguchi、Hirokazu Matsunaga、Kota Tomaya、Kohei Yamada

  DOI：10.1016/j.bmc.2014.04.041

  日期：2014.6

  Structure-activity relationships of 2-alkynyladenine derivatives were explored by varying substituents at the 9-, 8- and 2-positions of the purine moiety in order to optimize A(2A) adenosine receptor antagonist activity in vitro. A propargyl group at the 9-position was found to be important for A2A antagonist activity, and the introduction of a halogen, aryl, or heteroaryl at the 8-position further enhanced activity. A series of 8-substituted 2-alkynyl-N-9-propargyladenine derivatives exhibited potent antagonist activity, with IC50 values in the low nM range. Compound 4a from this series was found to be orally active at a dose of 3 mg/kg in a mouse catalepsy model and a 6-hydroxydopamine-lesioned rat model of Parkinson's disease. (C) 2014 Elsevier Ltd. All rights reserved.