Selective removal of electron-accepting p-toluene- and naphthalenesulfonyl protecting groups for amino function via photoinduced donor acceptor ion pairs with electron-donating aromatics
Ein synthetisches Analoges des Gramicidins S:<scp>C</scp>-(Val-Lys-Leu-Phe-Pro)<sub>2</sub>, (<scp>L</scp>-<scp>L</scp>-<scp>L</scp>-<scp>D</scp>-<scp>L</scp>)<sub>2</sub>. 6. Mitteilung über homodet cyclische Polypeptide
作者:R. Schwyzer、P. Sieber
DOI:10.1002/hlca.19580410614
日期:——
The synthesis of a bis-homo-gramicidin S, cyclo-(Val-Lys-Leu-Phe-Pro)2, 2HCl, H2O (L-L-L-D-L)2 is described. The product differs from gramicidinS in that the two residues of L-ornithine are replaced by residues of L-lysine. This change implies no significant loss of antibacterial properties. The antibiotic activity of gramicidine S is thus not due to the presence of the uncommon amino acid L-ornithine