2,5-bis(4-aminophenyl)thiophene | 70010-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-bis(4-aminophenyl)thiophene
• 英文别名: 4-(5-(4-Aminophenyl)thiophen-2-yl)benzenamine；4-[5-(4-aminophenyl)thiophen-2-yl]aniline
• CAS: 70010-49-0
• 化学式: C₁₆H₁₄N₂S
• 分子量: 266.367
• InChiKey: QUVIYFJRWXKEKM-UHFFFAOYSA-N

物化性质

• 熔点：
  240-241 °C
• 沸点：
  451.7±35.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,5-bis(4-aminophenyl)thiophene 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

  摘要：

  A series of bis-2,5-[4-guanidinophenyl]thiophenes were prepared in a five step process starting from 2,5-bis[trimethylstannyl]thiophene. The compounds were evaluated in vitro against Trypanosoma brucei rhodesiense (T. b. r.),, Plasmodium falciparum (P. f), Leshmania donovani (L. d.) and Trypanasoma cruzi (T. c.), and in vivo against T. b. r. Certain compounds show promising in vitro activity against T. b. r. and P. f and have superior in vivo activity against T. b. r. to that of pentamidine and furamidine. (c) 2007 Elsevier Masson SAS. All rights rights served.

  DOI：

  10.1016/j.ejmech.2006.11.006
• 作为产物：
  描述：

  1,4-二(4-溴苯基)丁烷-1,4-二酮 在 盐酸 、 ammonium hydroxide 、 氯仿 、 硫化氢 、 四氯化锡 、 copper(I) bromide 作用下， 生成 2,5-bis(4-aminophenyl)thiophene
  参考文献：
  名称：

  The Synthesis of 2,5-Diarylthiophenes

  摘要：

  DOI：

  10.1021/jo50010a023

文献信息

• [EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2011082077A1

  公开（公告）日：2011-07-07

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.

  本公开涉及抗病毒化合物，更具体地涉及能够抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白功能的化合物，包括这些化合物的组合物，以及抑制NS5A蛋白功能的方法。
• A porphyrin porous organic polymer with bicatalytic sites for highly efficient one-pot tandem catalysis
  作者：Rui Shen、Wei Zhu、Xiaodong Yan、Tao Li、Yong Liu、Yunxing Li、Siyuan Dai、Zhi-Guo Gu

  DOI：10.1039/c8cc08918c

  日期：——

  A novel porphyrin-based porous organic polymer PPOP-1(Pd) with bifunctional catalytic sites was constructed via imine condensation of tetra(4-aminophenyl)porphyrin and acenaphthenequinone. PPOP-1(Pd) containing Pd(II)-porphyrin and Pd(II)-α-diimine moieties exhibits excellent catalytic activity and outstanding reusability for tandem catalytic reactions of C–H arylation and Suzuki coupling.

  通过四（4-氨基苯基）卟啉与啶亚胺的亚胺缩合，构建了具有双功能催化位点的新型卟啉基多孔有机聚合物PPOP-1（Pd）。含有Pd（II）-卟啉和Pd（II）-α-二亚胺部分的PPOP -1（Pd）具有出色的催化活性和出色的可重复使用的C-H芳基化和Suzuki偶联反应。
• Elicitation effects of synthetic 1,2,4,5-tetraoxane and 2,5-diphenyltiophene in shoot cultures of two Nepeta species
  作者：Slavica Dmitrovic、Marijana Skoric、Jelena Boljevic、Neda Anicic、Dragana Bozic、Danijela Misic、Vuk Filipovic、Dejan Opsenica

  DOI：10.2298/jsc160226054d

  日期：——

  The present study was aimed to investigate the elicitation possibility of the main secondary metabolites production in Nepeta cataria L. and N. pannonica L. plants, by exposing them to synthetic compounds from the group of tetraoxanes and tiophenes. The effect of DO63 (1,2,4,5-tetraoxane) and DOVF15 (2,5-diphenyl-tiophene) on the production of cis,trans-nepetalactone (NL) and rosmarinic acid (RA) in two Nepeta species, was investigated in shoots grown on culture medium with addition of synthetic compounds in concentrations ranging from 0.1 to 2 mg L-1. The content of targeted metabolites in tested in vitro shoots depended on the type and the concentration of applied synthetic compounds. Application of DO63, primarily in concentration of 0.1 mg L-1 to 1 mg L-1, affected only NL production in both Nepeta species resulting in increased NL content in treated shoots, while production of RA was not influenced. Addition of DOVF15 caused decrease of RA content in N. pannonica shoots and increase in N. cataria shoots, whereas NL production was not affected. The presented results highlight the possibility of DO63 and DOVF15 application for the elicitation of the main secondary metabolites production in species from the genus Nepeta.

  本研究的目的是调查 Nepeta cataria L. 和 N. pannonica 主要次生代谢物产生的可能性。 L. 植物中主要次生代谢物产生的可能性。 四氧杂环己烷和噻吩类合成化合物。DO63（1,2,4,5-四氧杂环戊烷）和 DOVF15（2,5-二苯基噻吩）对顺式、反式庚内酯（NL）和迷迭香内酯（RL）生产的影响。 (和迷迭香酸（RA）的影响进行了研究。 在培养基上生长的嫩枝中，加入浓度为 浓度范围为 0.1 至 2 mg L-1。目标 代谢物的含量取决于所使用合成化合物的类型和浓度。 浓度而定。施用 DO63，主要是 浓度为 0.1 毫克/升-1 至 1 毫克/升-1 的 DO63 只影响 NL 的产生。 这两种植物的 NL 产量，结果是处理后的嫩芽中 NL 含量增加、 而 RA 的产生则不受影响。添加 DOVF15 会导致 pannonica 嫩芽中的 RA 含量降低，而 N. cataria 嫩芽中的 RA 含量降低，而 N. cataria 嫩芽中的 RA 含量增加，而 NL 产量未受影响。以上结果 结果表明，DO63 和 DOVF15 有可能诱导 的可能性。 Nepeta。
• Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
  申请人：——

  公开号：US20020156098A1

  公开（公告）日：2002-10-24

  Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula 1 wherein Y is a heteroatom; R 1 and R 2 are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X 1 , X 2 , and X 3 are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, acylamino, alkylthio, sulfonyl, cyano, carboxy, alkoxycarbonyl, or carbamoyl group are disclosed.

  本发明涉及用于治疗、预防或抑制利什曼病的方法，包括向受试者施用至少一种具有结构式1的化合物的治疗有效量，其中Y是杂原子；R1和R2分别是H或烷基、环烷基、杂环烷基、芳基、氨基或杂芳基基团；X1、X2和X3分别是H或烷基、烷氧基、卤素、氨基、烷基氨基、二烷基氨基、酰胺基、烷硫基、磺酰基、氰基、羧基、烷氧羰基或氨基甲酰基基团。
• Hepatitis C Virus Inhibitors
  申请人：Lopez Omar D.

  公开号：US20110294819A1

  公开（公告）日：2011-12-01

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.

  本公开涉及抗病毒化合物，更具体地涉及能够抑制丙型肝炎病毒（HCV）编码的NS5A蛋白功能的化合物，包括这些化合物的组合物以及抑制NS5A蛋白功能的方法。