N-aceto-2-chloro-6-methoxyaniline | 82344-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-aceto-2-chloro-6-methoxyaniline
• 英文别名: 2-Chloro-6-methoxyacetanilide；acetic acid-(2-chloro-6-methoxy-anilide)；Essigsaeure-(2-chlor-6-methoxy-anilid)；3-Chlor-2-diacetylamino-anisol；3-Chlor-2-acetamino-phenol-methylaether；3-Chlor-2-acetamino-anisol；N-(2-chloro-6-methoxyphenyl)acetamide
• CAS: 82344-35-2
• 化学式: C₉H₁₀ClNO₂
• 分子量: 199.637
• InChiKey: KEVMNNKAESKXQA-UHFFFAOYSA-N

物化性质

• 沸点：
  325.9±27.0 °C(Predicted)
• 密度：
  1.259±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-aceto-2-chloro-6-methoxyaniline 在 硝酸 作用下， 生成 acetic acid-(2-chloro-6-methoxy-4-nitro-anilide)
  参考文献：
  名称：

  Quinone Imides. XLIV. The Orientation of Groups in Addition Reactions to Substituted p-Quinonedibenzimides

  摘要：

  DOI：

  10.1021/ja01571a050
• 作为产物：
  描述：

  N-hydroxy-N-(2-methoxyphenyl)acetamide 在 氯化亚砜 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以84%的产率得到N-aceto-2-chloro-6-methoxyaniline
  参考文献：
  名称：

  Ayyangar, N. R.; Kalkote, U. R.; Nikrad, P. V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 9, p. 872 - 877

  摘要：

  DOI：

文献信息

• Phase Evolution During Sintering of Mullite/zirconia Composites Using Silica-coated Alumina Powders
  作者：V. Yaroshenko、D. S. Wilkinson

  DOI：10.1557/jmr.2000.0198

  日期：2000.6

  Mullite-based composites can be made by an in situ reaction process using silica-coated alumina (SCA) powder as a mullite precursor. In this paper we present the combined effects of zirconia and premullite seeds on the crystallization process and microstructure development. When zirconia is added without seeding, mullite formation proceeds through the formation of transient zircon. This phase provides a lower energy barrier for mullite nucleation and thus lowers the mullitization temperature. The presence of yttria as a stabilizer in zirconia reduces the activation energy for zircon formation and thus promotes the transient reaction. The addition of premullite seeds results in the nucleation of mullite from alumina and silica, and zircon does not form. At low seeding levels mullitization remains nucleation-controlled; however, once the seeding level exceeds 1–2%, this is no longer the case.

  莫来石基复合材料可通过使用硅包覆氧化铝（SCA）粉末作为莫来石前驱体的原位反应过程制成。本文介绍了氧化锆和莫来石种子对结晶过程和微观结构发展的综合影响。在不添加锆石种子的情况下，莫来石的形成是通过瞬态锆石的形成进行的。这一阶段为莫来石成核提供了较低的能量障碍，从而降低了莫来石化温度。氧化锆中作为稳定剂的钇的存在降低了锆石形成的活化能，从而促进了瞬态反应。添加前莫来石种子会导致氧化铝和二氧化硅形成莫来石晶核，而锆石不会形成。在低添加量时，莫来石化仍受成核控制；但一旦添加量超过 1-2%，情况就不再如此。
• Synthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines
  作者：R.Garth Pews、James E. Hunter、Richard M. Wehmeyer

  DOI：10.1016/s0040-4020(01)80400-2

  日期：1993.5

  A number of 2,6-disubstituted and 2,3,6-trisubstituted anilines have been prepared via the selective para dehalogenation of the corresponding anilines. Modification of the substituents on the amino nitrogen demonstrates that the selectivity is derived from steric rather than electronic effects. The effects of the choice of formate hydrogen donor, Pd catalyst, solvent, and temperature upon the efficiency and selectivity of the dehalogenation are discussed.
• Meldola; Eyre, Journal of the Chemical Society, 1902, vol. 81, p. 993
  作者：Meldola、Eyre

  DOI：——

  日期：——
• Novel orthohalogenation reaction. Synthesis of orthochloroarylamines from nitroarenes.
  作者：Nagaraj R. Ayyangar、Uttam R. Kalkote、Pandurang V. Nikrad

  DOI：10.1016/s0040-4039(00)87031-8

  日期：1982.1
• AYYANGAR, N. R.;KALKOTE, U. R.;NIKRAD, P. V., INDIAN J. CHEM., 1983, 22, N 9, 872-877
  作者：AYYANGAR, N. R.、KALKOTE, U. R.、NIKRAD, P. V.

  DOI：——

  日期：——