N-(4-methoxyphenethyl)-N-methylacetamide | 871894-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(4-methoxyphenethyl)-N-methylacetamide
• 英文别名: N-(4-methoxy-phenethyl)-N-methyl-acetamide；N-(4-Methoxy-phenaethyl)-N-methyl-acetamid；N-Methyl-N-acetyl-4-methoxy-β-phenaethylamin；N-acetyl-N-methyl-2-(4-methoxyphenyl)ethylamine；N-[2-(4-methoxyphenyl)ethyl]-N-methylacetamide
• CAS: 871894-82-5
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: ZHMQTRATDIYAGT-UHFFFAOYSA-N

物化性质

• 沸点：
  340.3±25.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-methoxyphenethyl)-N-methylacetamide 在 盐酸 、 氢碘酸 作用下， 生成 N-甲基酪胺
  参考文献：
  名称：

  Interactive Effect of Support From Family and Friends in Visually Impaired Elders

  摘要：

  The interactive relationship of high and low friend and family support for adaptation to chronic vision impairment was examined in 241 men and women. Two 2 (High/Low Family Support) X 2 (High/Low Friend Support) X 2 (Gender) multivariate analyses of covariance tested for psychological well-being, one with qualitative support measures, the other with quantitative support measures. Two analyses of covariance models tested for adaptation to vision loss. A significant multivariate 3-way interaction effect for qualitative support was found. Women with high support from both friends and family had better psychological well-being, whereas men with high support from both friends and family or just from family had better psychological well-being. Two univariate main effects showed that participants with high qualitative friend support and high quantitative family support had better adaptation to vision loss. Findings demonstrate the complexity of measuring and understanding relationships among social support, well-being, and domain-specific adaptation to chronic impairment.

  DOI：

  10.1093/geronb/56.6.p374
• 作为产物：
  描述：

  3-(4-甲氧基苯基)-丙酰胺 在 次溴酸钾 、 sodium acetate 、 sodium 、 xylene 作用下， 生成 N-(4-methoxyphenethyl)-N-methylacetamide
  参考文献：
  名称：

  Interactive Effect of Support From Family and Friends in Visually Impaired Elders

  摘要：

  The interactive relationship of high and low friend and family support for adaptation to chronic vision impairment was examined in 241 men and women. Two 2 (High/Low Family Support) X 2 (High/Low Friend Support) X 2 (Gender) multivariate analyses of covariance tested for psychological well-being, one with qualitative support measures, the other with quantitative support measures. Two analyses of covariance models tested for adaptation to vision loss. A significant multivariate 3-way interaction effect for qualitative support was found. Women with high support from both friends and family had better psychological well-being, whereas men with high support from both friends and family or just from family had better psychological well-being. Two univariate main effects showed that participants with high qualitative friend support and high quantitative family support had better adaptation to vision loss. Findings demonstrate the complexity of measuring and understanding relationships among social support, well-being, and domain-specific adaptation to chronic impairment.

  DOI：

  10.1093/geronb/56.6.p374

文献信息

• Enantioselective Synthesis of Chiral Tetrahydroisoquinolines by Iridium-Catalyzed Asymmetric Hydrogenation of Enamines
  作者：Pu-Cha Yan、Jian-Hua Xie、Guo-Hua Hou、Li-Xin Wang、Qi-Lin Zhou

  DOI：10.1002/adsc.200900602

  日期：2009.12

  Chiral iridium complexes based on spiro phosphoramidite ligands are demonstrated to be highly efficient catalysts for the asymmetric hydrogenation of unfunctionalized enamines with an exocyclic double bond. In combination with excess iodine or potassium iodide and under hydrogen pressure, the complex Ir/(Sa,R,R)-3a provides chiral N-alkyltetrahydroisoquinolines in high yields with up to 98% ee. The

  已证明基于螺亚磷酰胺配体的手性铱配合物是高效的催化剂，用于带有环外双键的未官能化烯胺的不对称氢化。与过量的碘或碘化钾结合并在氢气压力下，复合物Ir /（S a，R，R）-3a可提供高收率的手性N-烷基四氢异喹啉，ee可达98％。L / Ir比为2：1对于获得高反应速率和对映选择性至关重要。氘标记实验表明该反应中存在反同位素效应。还提出了可能的催化循环，包括带有两个单亚磷酰胺基配体的铱（III）物种。
• Isolation, Synthesis, and Biological Activity of Aphrocallistin, an Adenine-Substituted Bromotyramine Metabolite from the Hexactinellida Sponge <i>Aphrocallistes beatrix</i>
  作者：Amy E. Wright、Gregory P. Roth、Jennifer K. Hoffman、Daniela B. Divlianska、Diana Pechter、Susan H. Sennett、Esther A. Guzmán、Patricia Linley、Peter J. McCarthy、Tara P. Pitts、Shirley A. Pomponi、John K. Reed

  DOI：10.1021/np900183v

  日期：2009.6.26

  A new adenine-substituted bromotyrosine-derived metabolite designated as aphrocallistin (1) has been isolated from the deep-water Hexactinellida sponge Aphrocallistes beatrix. Its structure was elucidated on the basis of spectral data and confirmed through a convergent, modular total synthetic route that is amenable toward future analogue preparation. Aphrocallistin inhibits the growth of a panel of human tumor cell lines with IC50 values ranging from 7.5 to > 100 mu M and has been shown to induce G1 cell cycle arrest in the PANC-1 pancreatic carcinoma cell line. Aphrocallistin has been fully characterized in the NCI cancer cell line panel and has undergone in vitro ADME pharmacological profiling.
• [EN] NOVEL COMPOUNDS AND METHODS FOR INHIBITING P53 ACTIVITY<br/>[FR] COMPOSES ET PROCEDES ATYPIQUES D'INHIBITION D'ACTIVITE P53
  申请人：SINAI SCHOOL MEDICINE

  公开号：WO2007084625A2

  公开（公告）日：2007-07-26

  (EN) The present invention features compounds and pharmaceutical compositions comprising the same that are useful for modulating p53 activity. The invention further provides methods for inhibiting the biological activity of p53 and for treating diseases such as, for instance, cancer, cell death caused all or in part by cancer treatments such as chemotherapy or radiation thereapy, neuron cell death, stroke, Alzheimer's Disease and Parkinson's Disease.(FR) La présente invention concerne des composés et des compositions pharmaceutiques les comprenant, qui sont utiles pour la modulation d’activité p53. L’invention fournit aussi des procédés d’inhibition de l’activité biologique du p53 et de traitement de maladies telles que, par exemple, le cancer, la mort de cellules causées entièrement ou en partie par les traitements du cancer tels qu’une chimiothérapie ou une thérapie par radiation, la mort de cellules neuronales, un infarctus, la maladie d’Alzheimer et la maladie de Parkinson.
• Interactive Effect of Support From Family and Friends in Visually Impaired Elders
  作者：J. M. McIlvane、J. P. Reinhardt

  DOI：10.1093/geronb/56.6.p374

  日期：2001.11.1

  The interactive relationship of high and low friend and family support for adaptation to chronic vision impairment was examined in 241 men and women. Two 2 (High/Low Family Support) X 2 (High/Low Friend Support) X 2 (Gender) multivariate analyses of covariance tested for psychological well-being, one with qualitative support measures, the other with quantitative support measures. Two analyses of covariance models tested for adaptation to vision loss. A significant multivariate 3-way interaction effect for qualitative support was found. Women with high support from both friends and family had better psychological well-being, whereas men with high support from both friends and family or just from family had better psychological well-being. Two univariate main effects showed that participants with high qualitative friend support and high quantitative family support had better adaptation to vision loss. Findings demonstrate the complexity of measuring and understanding relationships among social support, well-being, and domain-specific adaptation to chronic impairment.