(2S,4R)-2-(氨基甲基)-4-氟吡咯烷-1-羧酸叔丁酯 | 1138324-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: (2S,4R)-2-(氨基甲基)-4-氟吡咯烷-1-羧酸叔丁酯
• 英文名称: tert-butyl (2S,4R)-2-(aminomethyl)-4-fluoropyrrolidinecarboxylate
• 英文别名: tert-butyl (2S,4R)-2-(aminomethyl)-4-fluoropyrrolidine-1-carboxylate
• CAS: 1138324-46-5
• 化学式: C₁₀H₁₉FN₂O₂
• 分子量: 218.271
• InChiKey: DADYKTRZKFJROI-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S,4R)-2-(氨基甲基)-4-氟吡咯烷-1-羧酸叔丁酯 在 4-二甲氨基吡啶 、 sodium cyanoborohydride 、 溶剂黄146 、 三乙胺 、 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 tert-butyl (2S,4R)-2-((N-(4-acetamidobenzyl)-4-(6-((cyclopropylmethyl)amino)imidazo[1,2-b]pyridazin-3-yl)benzamido)methyl)-4-fluoropyrrolidine-1-carboxylate
  参考文献：
  名称：

  Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo

  摘要：

  We have increased the potency of imidazo[1,2-b]pyridazine derivatives as IKK beta inhibitors with two strategies. One is to enhance the activity in cell-based assay by adjusting the polarity of molecules to improve permeability. Another is to increase the affinity for IKK beta by the introduction of additional substituents based on the hypothesis derived from an interaction model study. These improved compounds showed inhibitory activity of TNF alpha production in mice. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.078
• 作为产物：
  描述：

  N-Boc-顺式-4-羟基-L-脯氨酸甲酯 在 sodium azide 、 二乙胺基三氟化硫 、 二异丁基氢化铝 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 52.5h， 生成 (2S,4R)-2-(氨基甲基)-4-氟吡咯烷-1-羧酸叔丁酯
  参考文献：
  名称：

  4-氟和4-羟基吡咯烷-thioxotetrahydropyrimidinones：盐水中绿色不对称转化的有机催化剂。

  摘要：

  两者的合成反式-和顺pyrrolidinine-thioxotetrahydropyrimidinone轴承任一个氟或羟基的-diastereomers被完成。测试了这些新化合物在各种不对称有机转化中的催化性能，并与第一代催化剂进行了比较。已经发现，新型催化剂可以在不使用有机溶剂的情况下，并且通过使用几乎化学计量的试剂，可以有效地催化盐水中的反应。因此，通过简单的提取就可以分离出产物，从而避免了以极高的收率，非对映选择性和对映选择性使用色谱法。

  DOI：

  10.1021/acs.joc.5b00283

文献信息

• Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models
  作者：Hiroki Shimizu、Tomonori Yamasaki、Yoshiyuki Yoneda、Fumihito Muro、Tomoaki Hamada、Takanori Yasukochi、Shinji Tanaka、Tadashi Toki、Mika Yokoyama、Kaoru Morishita、Shin Iimura

  DOI：10.1016/j.bmcl.2011.05.115

  日期：2011.8

  We have discovered imidazo[1,2-b]pyridazine derivatives that show suppressive activity of inflammation in arthritis models. We optimized the substructures of imidazo[1,2-b] pyridazine derivatives to combine potent IKK beta inhibitory activity, TNF alpha inhibitory activity in vivo and excellent pharmacokinetics. The compound we have acquired, which had both potent activities and good pharmacokinetic profiles based on improved physicochemical properties, demonstrated efficacy on collagen-induced arthritis models in mice and rats. (C) 2011 Elsevier Ltd. All rights reserved.
• 4-Fluoro and 4-Hydroxy Pyrrolidine-thioxotetrahydropyrimidinones: Organocatalysts for Green Asymmetric Transformations in Brine
  作者：Nikolaos Kaplaneris、Giorgos Koutoulogenis、Marianna Raftopoulou、Christoforos G. Kokotos

  DOI：10.1021/acs.joc.5b00283

  日期：2015.6.5

  The synthesis of both trans- and cis-diastereomers of pyrrolidinine-thioxotetrahydropyrimidinone bearing either a fluorine or a hydroxyl group was accomplished. The new compounds were tested for their catalytic properties in a variety of asymmetric organic transformations and compared with the first generation catalyst. It was found that the new catalysts could efficiently catalyze the reactions in

  两者的合成反式-和顺pyrrolidinine-thioxotetrahydropyrimidinone轴承任一个氟或羟基的-diastereomers被完成。测试了这些新化合物在各种不对称有机转化中的催化性能，并与第一代催化剂进行了比较。已经发现，新型催化剂可以在不使用有机溶剂的情况下，并且通过使用几乎化学计量的试剂，可以有效地催化盐水中的反应。因此，通过简单的提取就可以分离出产物，从而避免了以极高的收率，非对映选择性和对映选择性使用色谱法。
• Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo
  作者：Hiroki Shimizu、Isao Yasumatsu、Tomoaki Hamada、Yoshiyuki Yoneda、Tomonori Yamasaki、Shinji Tanaka、Tadashi Toki、Mika Yokoyama、Kaoru Morishita、Shin Iimura

  DOI：10.1016/j.bmcl.2010.12.078

  日期：2011.2

  We have increased the potency of imidazo[1,2-b]pyridazine derivatives as IKK beta inhibitors with two strategies. One is to enhance the activity in cell-based assay by adjusting the polarity of molecules to improve permeability. Another is to increase the affinity for IKK beta by the introduction of additional substituents based on the hypothesis derived from an interaction model study. These improved compounds showed inhibitory activity of TNF alpha production in mice. (C) 2010 Elsevier Ltd. All rights reserved.