N-(γ,γ-dimethylallyl)-N'-(6-aminohexyl)-guanidine methanesulfonate | 714248-54-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-(γ,γ-dimethylallyl)-N'-(6-aminohexyl)-guanidine methanesulfonate
• 英文别名: N-(Y,Y-dimethylallyl)-N'-(6-aminohexyl)guanidine methane sulphonate；1-(6-aminohexyl)-2-(3-methylbut-2-enyl)guanidine;methanesulfonic acid
• CAS: 714248-54-1
• 化学式: CH₄O₃S*C₁₂H₂₆N₄
• 分子量: 322.472
• InChiKey: SBIIBTXOHQHDOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.09
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,N'-bis(tert-butoxycarbonyl)-N-(γ,γ-dimethylallyl)-S-methylisothiourea 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 4.0h， 生成 N-(γ,γ-dimethylallyl)-N'-(6-aminohexyl)-guanidine methanesulfonate
  参考文献：
  名称：

  Corelli, Federico; Federico, Rodolfo; Cona, Alessandra, Medicinal Chemistry Research, 2002, vol. 11, # 6, p. 309 - 321

  摘要：

  DOI：

文献信息

• [EN] VARIOUSLY SUBSTITUTED DERIVATIVES OF GUANIDINE, AND THEIR USE AS MEDICINES WITH ANTI-DIABETES AND/OR ANTI-OBESITY ACTIVITY<br/>[FR] DERIVES DE GUANIDINE SUBSTITUES DE DIVERSES MANIERES ET LEUR UTILISATION COMME MEDICAMENTS A ACTIVITE DE LUTTE CONTRE LE DIABETE ET/OU CONTRE L'OBESITE
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2004054967A1

  公开（公告）日：2004-07-01

  Formula (I) compounds are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. Said medicines are useful for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, and its complications, syndrome X, the various forms of insulin resistance, and hyperlipidaemias, as well as for the treatment of obesity.

  描述了公式（I）化合物，其中各个基团如文本中所识别，并且它们的用途作为药物，特别是作为抗糖尿病、降低血清葡萄糖和抗肥胖药剂。所述药物对于糖尿病的预防和治疗特别是2型糖尿病及其并发症，X综合症，各种形式的胰岛素抵抗以及高脂血症是有用的，同时也用于肥胖症的治疗。
• Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents
  作者：Emanuela Tassoni、Fabio Giannessi、Tiziana Brunetti、Pompeo Pessotto、Michela Renzulli、Massimiliano Travagli、Suvi Rajamäki、Samanta Prati、Secondo Dottori、Federico Corelli、Walter Cabri、Paolo Carminati、Maurizio Botta

  DOI：10.1021/jm8001636

  日期：2008.6.1

  We report the synthesis and evaluation of aminoalkylguanidine analogues and derivatives in C57BL/KsJ db/db diabetic mice, following identification by random screening of 1a and 1b as potential antihyperglycemics and/or modulators of food intake. These compounds are related to galegine, a gamma,gamma-dimethylallylguanidine. Between the newly identified compounds, 1h N-(cyclopropylmethyl)-N'-(4-(aminomethyl)cyclohexylmethyl)guanidine showed the most balanced activity as antihyperglycemic and food intake-reducing agent.
• Corelli, Federico; Federico, Rodolfo; Cona, Alessandra, Medicinal Chemistry Research, 2002, vol. 11, # 6, p. 309 - 321
  作者：Corelli, Federico、Federico, Rodolfo、Cona, Alessandra、Venturini, Giorgio、Schenone, Silvia、Botta, Maurizio

  DOI：——

  日期：——