1-Benzyl-6-bromo-4-dimethylaminomethyl-5-hydroxy-2-phenylsulfanylmethyl-1H-indole-3-carboxylic acid ethyl ester | 116736-30-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-Benzyl-6-bromo-4-dimethylaminomethyl-5-hydroxy-2-phenylsulfanylmethyl-1H-indole-3-carboxylic acid ethyl ester
• 英文别名: 1-benzyl-6-bromo-4-[(dimethylammonio)methyl]-3-(ethoxycarbonyl)-2-[(phenylsulfanyl)methyl]-1H-indol-5-olate；1-benzyl-6-bromo-4-[(dimethylazaniumyl)methyl]-3-ethoxycarbonyl-2-(phenylsulfanylmethyl)indol-5-olate
• CAS: 116736-30-2
• 化学式: C₂₈H₂₉BrN₂O₃S
• mdl: MFCD00329037
• 分子量: 553.52
• InChiKey: QGBWGFZKHSJGAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-Benzyl-6-bromo-5-hydroxy-2-phenylsulfanylmethyl-1H-indole-3-carboxylic acid ethyl ester 生成 1-Benzyl-6-bromo-4-dimethylaminomethyl-5-hydroxy-2-phenylsulfanylmethyl-1H-indole-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  PANISHEVA, E. K.;FOMINA, A. N.;NIKOLAEVA, I. S.;GALENKO-YAROSHEVSKIJ, P. +, XIM.-FARMATS. ZH., 22,(1988) N 5, 565-569

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL COMPOSITION WITH ANTI-DIABETIC ACTION
  申请人：Demin Alexander Victorovich

  公开号：US20100168092A1

  公开（公告）日：2010-07-01

  The invention relates to medicine, in particular to searching and developing novel medicinal agent for treating pancreatic diabetes. The invention is based on the development of more effective and less toxic medicinal agents based on indole derivatives which exhibit antidiabetic, hypolipidemic, hypoglycemic, hypocholesterolemic activity and insulin resistance-improving actions and the structure of which differs from the structure of traditionally used compounds. The inventive indole derivatives are also low-toxic and easily tolerated.

  本发明涉及医学领域，特别是寻找和开发治疗胰岛素糖尿病的新型药物。本发明基于开发基于吲哚衍生物的更有效和毒性更小的药物，这些药物表现出抗糖尿病，降脂，降血糖，降胆固醇活性和改善胰岛素抵抗作用，其结构与传统使用的化合物不同。本发明的吲哚衍生物也具有低毒性和易耐受性。
• ANTIDIABETIC PHARMACEUTICAL COMPOSITION
  申请人：Zakrytoe Aktsionernoe Obschestvo "Masterklon"

  公开号：EP2204173A1

  公开（公告）日：2010-07-07

  The invention relates to medicine, in particular to searching and developing novel medicinal agent for treating pancreatic diabetes. The invention is based on the development of more effective and less toxic medicinal agents based on indole derivatives which exhibit antidiabetic, hypolipidemic, hypoglycemic, hypocholesterolemic activity and insulin resistance-improving actions and the structure of which differs from the structure of traditionally used compounds. The inventive indole derivatives are also low-toxic and easily tolerated.

  本发明涉及医学，特别是寻找和开发治疗胰腺糖尿病的新型药剂。本发明以吲哚衍生物为基础，开发出更有效、毒性更低的药剂，这些衍生物具有抗糖尿病、降血脂、降血糖、降胆固醇活性和改善胰岛素抵抗的作用，其结构与传统使用的化合物结构不同。本发明的吲哚衍生物还具有低毒性和易耐受性。
• Synthesis and biological activity of 5-oxy-6-bromoindole substitutes
  作者：E. K. Panisheva、A. N. Fomina、I. S. Nikolaeva、P. A. Galenko-Yaroshevskii、V. V. Bartashevich、A. A. Cherkasova、S. N. Linchenko、A. L. Égik'yan、E. A. Golovanova、T. V. Pushkina

  DOI：10.1007/bf00769652

  日期：1988.5
• PANISHEVA, E. K.;FOMINA, A. N.;NIKOLAEVA, I. S.;GALENKO-YAROSHEVSKIJ, P. +, XIM.-FARMATS. ZH., 22,(1988) N 5, 565-569
  作者：PANISHEVA, E. K.、FOMINA, A. N.、NIKOLAEVA, I. S.、GALENKO-YAROSHEVSKIJ, P. +

  DOI：——

  日期：——
• US8247407B2
  申请人：——

  公开号：US8247407B2

  公开（公告）日：2012-08-21