1-Chlorosulfonyl-piperidine-2S-carboxylic acid benzyl ester | 343616-25-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Chlorosulfonyl-piperidine-2S-carboxylic acid benzyl ester
• 英文别名: benzyl (2S)-1-chlorosulfonylpiperidine-2-carboxylate
• CAS: 343616-25-1
• 化学式: C₁₃H₁₆ClNO₄S
• 分子量: 317.793
• InChiKey: MNRTWAOYIUNMIU-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-Chlorosulfonyl-piperidine-2S-carboxylic acid benzyl ester 、 3-氨基-6-吗啉基吡啶 在 3,5-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 以72%的产率得到AG-005774
  参考文献：
  名称：

  An efficient synthesis of sulfamides

  摘要：

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.106
• 作为产物：
  描述：

  1-chlorosulfonyl-piperidine-2S-carboxylic acid 4-phenyl-1-(3-phenyl-propyl)-butyl ester 、 (2S)-piperidine-2-carboxylic acid benzyl ester 以83%的产率得到1-Chlorosulfonyl-piperidine-2S-carboxylic acid benzyl ester
  参考文献：
  名称：

  Compounds, compositions, and methods for stimulating neuronal growth and elongation

  摘要：

  本发明涉及用于刺激神经元细胞中神经元生长的方法、药物化合物和组合物，从而导致神经再生。这些方法、化合物和组合物抑制了与结合蛋白相关的旋转酶酶活性。

  公开号：

  US20020061881A1

文献信息

• US6544987B2
  申请人：——

  公开号：US6544987B2

  公开（公告）日：2003-04-08
• An efficient synthesis of sulfamides
  作者：Chuangxing Guo、Liming Dong、Susan Kephart、Xinjun Hou

  DOI：10.1016/j.tetlet.2010.03.106

  日期：2010.5

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.
• Compounds, compositions, and methods for stimulating neuronal growth and elongation
  申请人：——

  公开号：US20020061881A1

  公开（公告）日：2002-05-23

  The present invention concerns methods, pharmaceutical compounds, and compositions for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.

  本发明涉及用于刺激神经元细胞中神经元生长的方法、药物化合物和组合物，从而导致神经再生。这些方法、化合物和组合物抑制了与结合蛋白相关的旋转酶酶活性。