2-phenoxy-butyric acid hydrazide | 31145-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-phenoxy-butyric acid hydrazide
• 英文别名: 2-Phenoxybutanohydrazide；2-phenoxybutanehydrazide
• CAS: 31145-69-4
• 化学式: C₁₀H₁₄N₂O₂
• mdl: MFCD01930259
• 分子量: 194.233
• InChiKey: XENRMFJZHMCGCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2-phenoxy-butyric acid hydrazide 、 S-methyl-N-phenylisothiourea hydroiodide 在 吡啶 作用下， 以68%的产率得到5-(1-phenoxypropyl)-N-phenyl-1H-1,2,4-triazol-3-amine
  参考文献：
  名称：

  Synthesis of some 3-arylamino-5-aryloxymethyl[1,2,4]triazole derivatives and their antimicrobial activity

  摘要：

  In this study, some 3-arylamino-5-aryloxymethyl[1,2,4]triazole derivatives were synthesized by reacting S-methyl-N'-arylisothiouronium iodide and 2-(aryloxy)alkanoic acid hydrazide. The structural elucidation of the compounds was performed by IR, 1H-NMR and MS spectroscopic data and elemental analyses results. Antibacterial and antifungal activities of the compounds were examined.

  DOI：

  10.1016/s0031-6865(97)00035-6

文献信息

• Zur Kenntnis der 2-Amino-1,3,4-oxdiazole Mitt.: 2-Amino-5-aryloxy(thio)alkyl-1,3,4-oxdiazole
  作者：H. Gehlen、K.-H. Uteg

  DOI：10.1002/ardp.19683011205

  日期：——

  Die Einwirkung von Bromcyan auf Aryloxy(thio)alkansäurehydrazide (I) führt zu den 2‐Amino‐5‐aryloxy(thio)alkyl‐1,3,4‐oxdiazolen (II). Einige Reaktionen von II, wie die Addition von Phenylisocyanant, die Alkoholyse und die Ringöffnung mit Acylhydrazinen werden beschrieben. Charakteristische IR‐Absorptionsbanden werden angegeben.

  溴化氰对芳氧基（硫代）链烷酸酰肼（I）的作用导致 2-氨基-5-芳氧基（硫代）烷基-1,3,4-恶二唑（II）。描述了II的一些反应，例如异氰酸苯酯的加成、醇解和与酰基肼的开环。给出了特征红外吸收带。
• Srivastava; Pathak; Bahel, Journal of the Indian Chemical Society, 1985, vol. 62, # 6, p. 486 - 487
  作者：Srivastava、Pathak、Bahel

  DOI：——

  日期：——
• SRIVASTAVA, A.;PATHAK, R. B.;BAHEL, S. C., J. INDIAN CHEM. SOC., 1985, 62, N 6, 486-487
  作者：SRIVASTAVA, A.、PATHAK, R. B.、BAHEL, S. C.

  DOI：——

  日期：——
• Synthesis of some 3-arylamino-5-aryloxymethyl[1,2,4]triazole derivatives and their antimicrobial activity
  作者：Şeref Demirayak、Kadriye Benkli、Kiymet Güven

  DOI：10.1016/s0031-6865(97)00035-6

  日期：1998.1

  In this study, some 3-arylamino-5-aryloxymethyl[1,2,4]triazole derivatives were synthesized by reacting S-methyl-N'-arylisothiouronium iodide and 2-(aryloxy)alkanoic acid hydrazide. The structural elucidation of the compounds was performed by IR, 1H-NMR and MS spectroscopic data and elemental analyses results. Antibacterial and antifungal activities of the compounds were examined.